Zeiss LSM710 Inverted Confocal Microscope

蔡司 LSM710 倒置共焦显微镜

• 批准号: 8826476
• 负责人: Jeffrey L Caplan
• 金额: $ 44.4万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8826476
• 关键词: 15 year old; Apoptosis; Arts; Biocompatible Materials; Biomechanics; Biomedical Engineering; Biomedical Research; Biotechnology; Cardiovascular system; Cells; Classification; Communities; Consult; Contract Services; Core Facility; Delaware; Development; Engineering; Ensure; Equipment; Eye Development; Funding; Generations; HIV; Housing; Image; Imaging Techniques; Institutes; Life; Manufacturer Name; Microscope; Microscopy; Osteogenesis; Process; Research; Research Activity; Research Personnel; Research Project Grants; Salivary Glands; Schedule; Science; System; Thrombosis; Tissues; Training; United States National Institutes of Health; Universities; Vascular Graft; bioimaging; college; instrument; meetings; research study; vocal cord

 DESCRIPTION (provided by applicant): The University of Delaware (UD) has a very high research activity (Carnegie Classification) and much of this activity focuses on diverse fields of biomedical research. In particular the College of Arts and Sciences and the College of Engineering depend heavily on advanced imaging instruments for research in tissues, cells and biomaterials. UD has maximized utilization of these instruments with an established multi-user imaging core facility, which is responsible for maintaining, scheduling equipment usage, training users and consulting on advanced technical projects or development of new imaging techniques. One of the first confocal microscopes we acquired at UD, an LSM510 VIS confocal microscope, is housed in the Delaware Biotechnology Institute (DBI) Bio-Imaging Center at UD. The instrument is now 15 years old and no longer in use due to poor image quality and the manufacturer no longer providing service contracts as of September 2009. This application is a resubmission requesting funds to replace this obsolete instrument, which no longer meets the needs of our user community, with an LSM710 inverted confocal microscope with an environmental chamber. The proposed system will be located in the microscopy suite at the DBI and administered by the Bio- Imaging Center technical staff. This will ensure access to the proposed microscope to all investigators who utilize the DBI Bio-Imaging Center, which is a critical core facility for numerous NIH funded research projects at UD. Currently, the DBI Bio-Imaging Center only has LSM510 generation inverted confocal microscopes that lack the sensitivity and environmental control for live-cell experiments. Therefore, we are requested an LSM710 inverted confocal microscope to support NIH funded investigators researching a diverse array of biomedical processes that include engineering vascular grafts, programmed cell death, cardiovascular, biomechanics, salivary glands, vocal fold bioengineering, eye development, thrombosis, bone formation and HIV assembly.

 描述（由申请人提供）：特拉华大学 (UD) 拥有非常高的研究活动（卡内基分类），其中大部分活动集中于生物医学研究的各个领域，特别是文理学院和工程学院。 UD 严重依赖先进的成像仪器进行组织、细胞和生物材料的研究，通过建立的多用户成像核心设施最大限度地利用这些仪器，该设施负责维护、安排设备使用、培训用户以及先进技术项目的咨询。或开发新的我们在 UD 购买的第一批共焦显微镜之一是 LSM510 VIS 共焦显微镜，位于 UD 的特拉华州生物技术研究所 (DBI) 生物成像中心，该仪器已有 15 年历史，因不再使用。由于图像质量差，并且制造商自 2009 年 9 月起不再提供服务合同。此申请是重新提交，要求资金更换这种过时的仪器，该仪器不再满足我们用户的需求拟议的系统将位于 DBI 的显微镜套件中，并由生物成像中心技术人员管理，这将确保所有使用该显微镜的研究人员都能使用该显微镜。 DBI 生物成像中心是 UD 众多 NIH 资助研究项目的关键核心设施，目前，DBI 生物成像中心只有 LSM510 一代倒置共聚焦显微镜，缺乏因此，我们需要一台 LSM710 倒置共聚焦显微镜来支持 NIH 资助的研究人员研究各种生物医学过程，包括工程血管移植、程序性细胞死亡、心血管、生物力学、唾液腺、声乐。折叠生物工程、眼睛发育、血栓形成、骨形成和艾滋病毒组装。