Translational Neuroimaging & Neurophysiology Core

转化神经影像学

• 批准号: 10633150
• 负责人: JIANHUI ZHONG
• 金额: $ 18.51万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633150
• 关键词: 3-Dimensional; Acceleration; Address; Adult; Anatomy; Animals; Archives; Augmented Reality; Biological Assay; Biological Markers; Brain; Brain imaging; Cell Nucleus; Cells; Child; Childhood; Cognitive; Collaborations; Collection; Complex; Computer software; Consult; Data; Data Analyses; Dedications; Development; Disease; Disease Progression; Electrodes; Electroencephalography; Electrophysiology (science); Elements; Environment; Event-Related Potentials; Experimental Designs; Faculty; Frequencies; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Gait; Goals; Grant; Group Meetings; Human; Image; Imaging Device; Imaging Techniques; Individual; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Investigation; Learning; Letters; Link; Magnetic Resonance Imaging; Marker Discovery; Measurement; Measures; Medical center; Methodology; Methods; Modernization; Motion; Motor; Participant; Patients; Persons; Phenotype; Physiologic pulse; Population; Positron-Emission Tomography; Postdoctoral Fellow; Posture; Procedures; Productivity; Protocols documentation; Research; Research Personnel; Research Project Grants; Resolution; Resources; Sensory; Services; Spielmeyer-Vogt Disease; Students; Supervision; System; Systems Integration; Techniques; Testing; Time; Training; Translational Research; United States National Institutes of Health; Universities; Walking; Work; analysis pipeline; animal data; auditory processing; college; computerized data processing; cost; data acquisition; data analysis pipeline; data repository; data submission; density; design; developmental disease; experience; human data; imaging capabilities; imaging modality; imaging system; improved; innovation; interest; investigator training; juvenile neuronal ceroid lipofuscinosis; magnetic resonance imaging/electroencephalography; member; molecular imaging; mouse model; multimodality; neural; neuroimaging; neurophysiology; next generation; nonhuman primate; novel; patient population; reconstruction; recruit; repository; square foot; synergism; tool; transmission process; virtual; virtual reality; virtual reality environment; visual tracking

PROJECT SUMMARY Both new investigators with an interest in testing IDD-related hypotheses and experienced investigators who may wish to expand their research portfolios to address important IDD-related issues often find that there are structural barriers to entry into a new research path. High costs of modern imaging techniques, the specialized technical aspects of experimental design, data acquisition and analysis, as well as working with new patient populations can each constrain execution of important translational research. The purpose of the Translational Neurophysiology and Neuroimaging Core (TNN) is to provide access to a set of modern (if complex) tools, access to the professional expertise so that use of these tools can be productive, and access to an intellectual environment that encourages and supports new and ongoing research on IDDs. To accomplish these important goals, the TNN has a set of aims that include providing UR-IDDRC members access to human and small animal neuroimaging tools (3T and 9.4T MRI), human and small animal electroencephalography (EEG), Mobile Brain/Body Imaging, and access to pilot funding to defray the costs of using these tools to jump-start new IDD research. TNN faculty and staff will consult with investigators on the design of the experiment, assist with the implementation of protocols and train investigators and/or their trainees (postdocs and students) to perform the data processing and analyses. A monthly users group meeting also allows new investigators to learn about current protocols, capabilities and ongoing projects that might synergize with their own proposed work, and to develop collaborative relationships with other TNN investigators. In addition to this general support for UR-IDDRC members, the TNN core also supports the proposed research project “Bridging the translational divide from cells to patients: toward reliable neuro-markers of Batten disease.” Aim 1 of the research project proposes to investigate auditory processing in children with Juvenile Neuronal Ceroid Lipofuscinosis in an effort to construct a neurophysiological biomarker of disease progression. Aim 2 of the research project proposes develop an identical EEG-based neuromarkers in murine models of Batten disease. The TNN serves as the hub for murine model EEG and also human EEG in people with and without IDDs. The facilities and services described in this core will be key elements to successful completion of the Aims of the research project.

项目摘要 两个新的调查人员都对测试IDD相关的假设和经验丰富的研究人员都有兴趣 谁可能希望扩大其研究组合以解决重要的IDD相关问题，通常会发现 是进入新研究道路的结构性障碍。现代成像技术的高成本， 实验设计，数据获取和分析以及与之合作的专业技术方面 新的患者人群可以约束重要的转化研究。目的 翻译神经生理学和神经影像学核心（TNN）是提供对一组现代的访问（如果 复杂）工具，访问专业知识，以便使用这些工具可以有效，并访问 智力环境鼓励并支持对IDD的新研究。到 实现这些重要目标，TNN具有一系列目标，包括提供UR-IDDRC成员 获取人类和小动物神经影像学工具（3T和9.4T MRI），人和小动物 脑电图（EEG），移动大脑/身体成像以及获取飞行员资金以支付成本 使用这些工具开始启动新的IDD研究。 TNN教职员工将向调查人员咨询有关 实验的设计，协助实施协议和培训调查人员和/或其 学员（博士后和学生）进行数据处理和分析。每月用户小组会议 还允许新调查人员了解当前的协议，功能和正在进行的项目 与他们自己的拟议工作协同作用，并与其他TNN建立合作关系 调查人员。 除了对UR-IDDRC成员的一般支持外，TNN核心还支持提议的 研究项目“将翻译鸿沟从细胞到患者桥接：向可靠的神经标记物 “研究项目提案的目标1，以调查患有儿童的听觉处理 青少年神经蛋白脂肪促肌动症，以构建神经生理生物学生物标志物 进展。研究项目的目标2在鼠中开发了相同的基于脑电图的神经标志物 棕褐色疾病的模型。 TNN充当鼠模型脑电图的枢纽，而人类也是人类的脑电图 有和没有IDD。此核心中描述的设施和服务将是成功的关键要素 完成研究项目的目标。