Hyperspectral Single Photon Imaging of Targeted Alpha-Emitters

目标阿尔法发射器的高光谱单光子成像

基本信息

  • 批准号:
    10633193
  • 负责人:
  • 金额:
    $ 58.21万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-01 至 2025-03-31
  • 项目状态:
    未结题

项目摘要

Targeted alpha-emitter therapy (TAT) is an emerging modality in the cancer therapy. By directly killing cancer cells it is less susceptible to development of resistance. Combination of external beam radiation therapy (XRT) and TATs have a high potential for treatment of systemic disease: the XRT is effective for a small number of large tumors, and the TAT for small, widely disseminated metastases. To understand the targeting behavior and dose response, dosimetry information is required in preclinical and early-stage clinical studies. Estimates of the dose distribution are essential for optimal planning of TAT alone and combined with XRT. Knowledge of the dose distribution from TATs could shorten clinical trials by helping select patients for whom the therapy is most likely to be effective, and by shortening Phase 1 dose escalation trials by using knowledge of toxicities obtained from XRT experience. The distribution of the radionuclide in vivo is a prerequisite for estimating TAT dose distribution. For alpha emitters, there are several significant challenges. Due to their high linear energy transfer and resulting lethality, low doses are commonly used. Also, the spectrum typically has many low-abundance gamma rays spread over a wide energy range combined with characteristic x-rays. Typical decay chains include multiple daughter radionuclides, and it is important to estimate their activity distributions. These capabilities would be enabled by an advanced SPECT system with high sensitivity and high spatial and energy resolution. In this project, we will develop the Alpha-SPECT system, a novel scanner aimed at imaging of these radionuclides. It uses advanced spectroscopic CZT imaging detectors to provide excellent spatial resolution, ultrahigh sensitivity, and excellent energy resolution of these radionuclides in large animals. To achieve this, we will push the forefront of CZT detector technology a generation ahead of the current state-of-art commercial CZT-based gamma-ray detectors. We will combine this CZT-based detection system with the novel synthetic compound-eye gamma camera design to realize the Alpha-SPECT system. We will develop quantitative reconstruction methods and web-based interface for this system to estimate the distribution of the parent and daughter radionuclides. Finally, we will evaluate the system and reconstruction method using phantom and large animal imaging studies using TATs that are currently under development at Johns Hopkins to validate the system. We will market access to the system as a core service to the cancer research community through Johns Hopkins and, through Rapid, LLC, to commercial drug developers. This project will not only serve as a critical step to bring the unique spectral SPECT imaging capability to end users who are currently developing targeted radionuclide therapies, but it also will potentially lead to a state-of-art spectral-CZT detector platform for use by the research community and industry in developing the next generation clinical SPECT instrumentations for applications beyond targeted radionuclide therapies. This prosed project has a clear pathway to serve a much broader spectrum of end-users.
靶向α-发射体疗法(TAT)是癌症治疗中的一种新兴方式。通过直接杀死癌症 细胞不太容易受到阻力发展。外束辐射疗法(XRT)的结合 TAT具有很高的全身性疾病治疗潜力:XRT对少数数量有效 大肿瘤和小型肿瘤,用于小型,广泛散布的转移。了解目标行为和 临床前和早期临床研究中需要剂量反应,剂量测定信息。估计 剂量分布对于单独使用TAT并与XRT结合使用至关重要。剂量的知识 从TATS分发可以通过帮助选择治疗的患者来缩短临床试验 通过使用从 XRT经验。放射性核素在体内的分布是估计TAT剂量分布的先决条件。 对于Alpha发射器,存在一些重大挑战。由于它们的高线性能量传递和结果 致死性,低剂量通常使用。此外,频谱通常具有许多低充足的伽马射线 分布在广泛的能量范围内,结合了特征X射线。典型的衰减链包括多个 女儿放射性核素,估计其活性分布很重要。这些功能将是 由具有高灵敏度,高空间和能量分辨率的高级SPECT系统启用。在这个 项目,我们将开发Alpha-Spect System,这是一种旨在对这些放射性核素进行成像的新型扫描仪。它 使用高级光谱CZT成像探测器可提供出色的空间分辨率,超高灵敏度, 这些放射性核素在大动物中的出色能量分辨率。为了实现这一目标,我们将推动最前沿 CZT探测器技术的一代领先于当前的先进商业CZT伽马射线 探测器。我们将将此基于CZT的检测系统与新型合成化合物伽玛相结合 相机设计实现Alpha-specs系统。我们将开发定量重建方法,并 该系统的基于Web的界面估计父和女儿放射性核素的分布。最后, 我们将使用幻影和大型动物成像研究评估系统和重建方法 目前正在约翰·霍普金斯(Johns Hopkins)开发的TAT验证该系统。我们将销售 该系统是通过约翰·霍普金斯(Johns Hopkins)以及快速, 有限责任公司,致商业药品开发商。该项目不仅将成为带来独特光谱的关键步骤 SPECT成像能力为目前正在开发目标放射性核素疗法的最终用户,但也 可能会导致一个最先进的光谱CZT检测器平台,以供研究界和 为超越目标的应用开发下一代临床仪器仪器的行业 放射性核素疗法。这个宽松的项目具有清晰的途径,可以为最终用户提供更广泛的范围。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Experimental Evaluation of a 3-D CZT Imaging Spectrometer for Potential Use in Compton-Enhanced PET Imaging.
Experimental validation of a rodent PET scanner prototype based on a single LYSO crystal tube.
  • DOI:
    10.1109/trpms.2021.3124448
  • 发表时间:
    2022-07
  • 期刊:
  • 影响因子:
    4.4
  • 作者:
    Freire, Marta;Gonzalez-Montoro, Andrea;Canizares, Gabriel;Rezaei, Ahmadreza;Nuyts, Johan;Berr, Stuart S.;Williams, Mark B.;Benlloch, Jose M.;Gonzalez, Antonio J.
  • 通讯作者:
    Gonzalez, Antonio J.
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Yong Du其他文献

Yong Du的其他文献

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{{ truncateString('Yong Du', 18)}}的其他基金

Alpha-emitter Imaging for Dosimetry and Treatment Planning
用于剂量测定和治疗计划的阿尔法发射体成像
  • 批准号:
    10713710
  • 财政年份:
    2023
  • 资助金额:
    $ 58.21万
  • 项目类别:
High Energy and Spatial Resolution Multi-Isotope SPECT Imaging of Targeted Alpha-Emitters and their Daughters
目标α发射体及其子体的高能量和空间分辨率多同位素 SPECT 成像
  • 批准号:
    10275637
  • 财政年份:
    2021
  • 资助金额:
    $ 58.21万
  • 项目类别:
High Energy and Spatial Resolution Multi-Isotope SPECT Imaging of Targeted Alpha-Emitters and their Daughters
目标α发射体及其子体的高能量和空间分辨率多同位素 SPECT 成像
  • 批准号:
    10470322
  • 财政年份:
    2021
  • 资助金额:
    $ 58.21万
  • 项目类别:
Hyperspectral Single Photon Imaging of Targeted Alpha-Emitters
目标阿尔法发射器的高光谱单光子成像
  • 批准号:
    10436389
  • 财政年份:
    2021
  • 资助金额:
    $ 58.21万
  • 项目类别:
Hyperspectral Single Photon Imaging of Targeted Alpha-Emitters
目标阿尔法发射器的高光谱单光子成像
  • 批准号:
    10311159
  • 财政年份:
    2021
  • 资助金额:
    $ 58.21万
  • 项目类别:
High Energy and Spatial Resolution Multi-Isotope SPECT Imaging of Targeted Alpha-Emitters and their Daughters
目标α发射体及其子体的高能量和空间分辨率多同位素 SPECT 成像
  • 批准号:
    10703387
  • 财政年份:
    2021
  • 资助金额:
    $ 58.21万
  • 项目类别:
Multi-Modality Quantitative Imaging for Evaluation of Response to Cancer Therapy
用于评估癌症治疗反应的多模态定量成像
  • 批准号:
    10437852
  • 财政年份:
    2011
  • 资助金额:
    $ 58.21万
  • 项目类别:
Multi-Modality Quantitative Imaging for Evaluation of Response to Cancer Therapy
用于评估癌症治疗反应的多模态定量成像
  • 批准号:
    10208790
  • 财政年份:
    2011
  • 资助金额:
    $ 58.21万
  • 项目类别:

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  • 批准号:
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  • 财政年份:
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