Training Program in Musculoskeletal Research

肌肉骨骼研究培训计划

• 批准号: 10629226
• 负责人: RONALD J TRIOLO
• 金额: $ 35.54万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629226
• 关键词: Musculoskeletal; Research; Training Programs

7. Project Summary/Abstract The missions of this longstanding Training Grant are to provide training in musculoskeletal research to academically gifted individuals at the predoctoral and postdoctoral level and to develop these individuals towards productive careers in musculoskeletal research. The strong interdisciplinary nature of musculoskeletal research at CWRU provides an ideal framework for developing the trainees’ research expertise as well as their appreciation for the importance of interdisciplinary approaches and their interest in musculoskeletal diseases. The faculty are highly collaborative and interactive and include 21 Training Mentors plus 13 Associate Mentors from fourteen departments in the School of Medicine, the School of Engineering, the College of Arts and Sciences, and the Cleveland Clinic Lerner Research Institute. There is a healthy mixture of biological-, engineering-, and clinical-oriented trainers, further emphasizing the importance of interdisciplinary approaches. Training is provided for two or three years to 4 predoctoral and 3 postdoctoral trainees per year. These outstanding individuals are identified by a careful, multi-step selection process. Training occurs through intensive participation in research projects as well as through a rigorous curriculum of courses, seminar, and conferences. The Director and Co-Directors are assisted by a Steering Committee and an Advisory Committee that formally review the overall program as well as the progress of each trainee on a regular basis. The success of the program is best appreciated by considering the career trajectories of our former trainees. 22 of them have obtained faculty positions at universities across the country and thirteen have developed federally-funded research programs. An additional nine current and recent trainees are in various stages of their continued training and plan research careers. Moreover, 79% of the trainees from the previous two funding periods are actively engaged in biomedical research/academics. Training future musculoskeletal researchers is crucial since musculoskeletal diseases are major causes of morbidity, mortality, and impaired quality of life for millions of people in the United States and the number of affected individuals will continue to increase in frequency as our population ages.

7。项目摘要/摘要 这项长期培训赠款的任务是为肌肉骨骼研究提供培训 在学术界和博士后层面上有才华的人，并发展这些人 致力于肌肉骨骼研究的生产力。强大的跨学科性质 CWRU的肌肉骨骼研究为开发培训研究提供了理想的框架 专业知识以及对跨学科方法重要性及其对他们对的兴趣的赞赏 肌肉骨骼疾病。该教师具有高度协作和互动性，包括21个培训 导师加上医学院14个系的13位副导师 工程学，艺术与科学学院以及克利夫兰诊所Lerner研究所。有一个 生物学，工程和面向临床的教练的健康混合物，进一步强调了 跨学科方法的重要性。提供两到三年的培训至4个培训 和每年3名博士后学员。这些杰出的人是通过仔细的多步骤来识别的 选择过程。培训是通过密集地参与研究项目以及通过 严格的课程，开创性和会议的课程。董事和联合导演由 指导委员会和咨询委员会正式审查整体计划以及 每个学员定期的进度。该计划的成功得到了最好的赞赏 考虑到我们前学员的职业轨迹。他们中有22位在 全国各地的大学和13个大学制定了联邦资助的研究计划。一个 其他九名现任和最近的学员仍处于继续培训和计划的各个阶段 研究事业。此外，前两个融资期的培训中有79％是积极的 从事生物医学研究/学者。培训未来的肌肉骨骼研究人员至关重要 肌肉骨骼疾病是数百万的发病率，死亡率和生活质量受损的主要原因 美国的人和受影响个人的人数将继续增加 随着我们的人口年龄。

项目成果

Prospective Evaluation of Repeatability and Robustness of Radiomic Descriptors in Healthy Brain Tissue Regions In Vivo Across Systematic Variations in T2-Weighted Magnetic Resonance Imaging Acquisition Parameters.

• DOI: 10.1002/jmri.27635
• 发表时间: 2021-09
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Eck B;Chirra PV;Muchhala A;Hall S;Bera K;Tiwari P;Madabhushi A;Seiberlich N;Viswanath SE
• 通讯作者: Viswanath SE

Coefficient of Friction Patterns Can Identify Damage in Native and Engineered Cartilage Subjected to Frictional-Shear Stress.

• DOI: 10.1007/s10439-015-1269-8
• 发表时间: 2015-09
• 期刊: Annals of biomedical engineering
• 影响因子: 3.8
• 作者: Whitney GA;Mansour JM;Dennis JE
• 通讯作者: Dennis JE

Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK.

• DOI: 10.1002/jcp.21539
• 发表时间: 2008-12
• 期刊: JOURNAL OF CELLULAR PHYSIOLOGY
• 影响因子: 5.6
• 作者: Beidelschies, Michelle A.;Huang, Honglian;McMullen, Megan R.;Smith, Matthew V.;Islam, Andrew S.;Goldberg, Victor M.;Chen, Xin;Nagy, Laura E.;Greenfield, Edward M.
• 通讯作者: Greenfield, Edward M.

Reflex bladder activation via pudendal nerve and intraurethral stimulation depends on stimulation pattern and location.

通过阴部神经和尿道内刺激的反射性膀胱激活取决于刺激模式和位置​​。

• DOI: 10.1109/iembs.2008.4649774
• 发表时间: 2008
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Bruns,TimM;Gustafson,KennethJ;Bhadra,Narendra
• 通讯作者: Bhadra,Narendra

Volumetric MicroCT Intensity Histograms of Fatty Infiltration Correlate with the Mechanical Strength of Rotator Cuff Repairs: An Ex Vivo Rabbit Model.

脂肪浸润的体积 MicroCT 强度直方图与肩袖修复的机械强度相关：离体兔模型。

• DOI: 10.1097/corr.0000000000001540
• 发表时间: 2021
• 期刊: Clinical orthopaedics and related research
• 影响因子: 4.2
• 作者: McClellan,PhillipE;Kesavan,Lekha;Wen,Yujing;Ina,Jason;Knapik,DerrickM;Gillespie,RobertJ;Akkus,Ozan;Webster-Wood,VictoriaA
• 通讯作者: Webster-Wood,VictoriaA