University of New Mexico Center for Metals in Biology and Medicine

新墨西哥大学生物和医学金属中心

• 批准号: 10629336
• 负责人: Matthew J Campen
• 金额: $ 224.89万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629336
• 关键词: Analytical Chemistry; Area; Binding; Biochemistry; Biology; Biomedical Research; Cancer Biology; Centers of Research Excellence; Characteristics; Chemistry; Clinical; Clinical Sciences; Communities; Community Health; Community Outreach; Complex; Computers and Advanced Instrumentation; Core Facility; Development; Disease; Drug Delivery Systems; Environmental Hazards; Environmental Health; Exhibits; Extramural Activities; Faculty; Funding; Funding Opportunities; Goals; Growth; Health; Health Benefit; Health Sciences; Heavy Metals; High Prevalence; Home; Human; Immunology; Inorganic Chemistry; Intervention; Investigation; Knowledge; Leadership; Link; Lung; Malignant Neoplasms; Medical; Medicine; Mentors; Mentorship; Metals; Mexican; Mining; Molecular; Molecular Analysis; Native Americans; Neurologic; Neurosciences; New Mexico; Nutritional; Outcome; Patients; Physiology; Play; Population; Prevalence; Principal Investigator; Productivity; Property; Public Health; Recording of previous events; Research; Research Personnel; Research Training; Resources; Risk Assessment; Role; Science; Scientist; Services; Southwestern United States; Therapeutic; Tissue Model; Toxicology; Toxin; Training; Transition Elements; Translational Research; Underserved Population; Universities; Work; biological systems; career; career development; chemical property; community intervention; environmental toxicology; global health; improved; innovation; member; metallicity; multidisciplinary; novel; nutrition; operation; programs; receptor; wasting

Inorganic metals have long been a focus of biomedical research in New Mexico, due to the high prevalence of mining-related metal contaminants in the region. At the University of New Mexico Center for Metals in Biology and Medicine (UNM CMBM) our main focus will be on both studying adverse health outcomes (including cancer, pulmonary, neurologic, and other disorders) of metal contaminants as well as on harnessing the chemical properties of metals for therapeutic and nutritional purposes. Detailed knowledge of molecular interactions between metallic species and biomolecules can lead to clinical and population-level interventions to improve public health. While heavy and transition metals exhibit both medical and toxicological characteristics, the molecular and cellular interactions are often inadequately understood. The UNM CMBM will combine expertise in inorganic chemistry, analytical chemistry, and metal mixtures toxicology to add sophistication and translational value to the research of mentored principal investigators (mPIs). Recent discoveries from members of the mentorship team and mPIs highlight the need for greater depth of molecular inquiry in studying metal interactions with biomolecular targets, as such detailed understanding permits improvements in receptor targeting (in the case of medicines) or innovative interventions (in the case of environmental hazards). By providing intellectual expertise and advanced instrumentation to aid the mPIs' research endeavors, we will enhance their funding opportunities and career progression to full independence. The mentors in our program have a strong history of successful junior faculty career development, which we will further enhance within the framework of this P20 Center by promoting the key concepts of multidisciplinary team science and translational research approaches. Our long-term goal is to establish a nationally recognized program of well-funded researchers conducting innovative research on metals toxicology and biomedicine that has positive impacts on New Mexican and Southwestern communities. We will achieve this goal through the following three specific aims: Aim 1. Create a strong community of independent investigators with common research goals related to metals in medicine and biology. Aim 2. Establish centralized research Integrative Molecular Analysis Core Facility by integrating existing UNM-Health Science Center (HSC) scientific resources and building innovative facilities to improve bioanalytical chemistry research training and productivity for mPIs, as well as to bolster research quality and depth for our institute. Aim 3. Create a unique “Metals in Biology and Medicine” program that has clear T0-T4 translational value. The successful implementation of this Center will lead to growth in independent research funding at UNM, especially among junior investigators achieving independent career goals. The outcomes of our program have clear clinical and public health benefit to populations and communities in the southwest, including the numerous Native American populations disproportionately impacted by legacy waste from mining operations. 1

由于高流行率，无机金属长期以来一直是新墨西哥州生物医学研究的重点 该地区与采矿相关的金属污染物。在新墨西哥大学生物学中心 和医学（UNM CMBM）我们的主要重点将是研究不良健康结果（包括 金属污染物的癌症，肺，神经系统和其他疾病以及利用 用于热和营养目的的金属的化学特性。分子的详细知识 金属物种与生物分子之间的相互作用会导致临床和人群水平的干预措施 改善公共卫生。虽然重金属和过渡金属均暴露于医学和毒理学 特征，分子和细胞相互作用通常不充分理解。 UNM CMBM 将结合无机化学，分析化学和金属混合毒理学的专业知识来添加 社会化和对指导主要研究人员（MPI）研究的转化价值。最近的 Mentalship团队成员和MPI的发现强调了需要更深入的分子深度 研究金属与生物分子靶标的金属相互作用的询问，如这样详细的理解许可 改善受体靶向（对于药物）或创新干预措施（如果是 环境危害）。通过提供智力专业知识和先进的工具来帮助MPI 研究努力，我们将增强他们的资金机会和职业发展，从而充分独立。 我们计划中的导师在成功的初级教师职业发展方面有很强的历史 通过促进多学科的关键概念，将在该P20中心的框架内进一步增强 团队科学和翻译研究方法。我们的长期目标是在全国范围内建立 公认的资金资助的研究人员计划，对金属毒理学和 生物医学对新墨西哥州和西南部社区产生积极影响。我们将实现这一目标 通过以下三个特定目标进行目标：目标1。创建一个强大的独立研究人员社区 具有与医学和生物学金属有关的常见研究目标。目标2。建立集中研究 整合分子分析核心设施通过整合现有的不健康科学中心（HSC） 科学资源和建立创新设施，以改善生物分析化学研究培训和 MPI的生产力，以及为我们的研究所增强研究质量和深度的生产率。目标3。创建一个独特的 具有清晰的T0-T4翻译价值的“生物学和医学中的金属”计划。成功 该中心的实施将导致UNM的独立研究资金增长，尤其是在 初级调查人员实现了独立的职业目标。我们计划的结果有明确的临床和 西南人口和社区的公共卫生益处，包括众多本地人 美国人口受到采矿业务的遗产废物的影响不成比例。 1

项目成果

Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches.

• DOI: 10.1016/j.dnarep.2021.103126
• 发表时间: 2021-07
• 期刊: DNA repair
• 影响因子: 3.8
• 作者: Duan M;Speer RM;Ulibarri J;Liu KJ;Mao P
• 通讯作者: Mao P

Evolution of COVID-19 in patients with autoimmune rheumatic diseases.

• DOI: 10.18632/aging.202193
• 发表时间: 2020-12-03
• 期刊: Aging
• 作者: Pang R;Zhao J;Gan Z;Hu Z;Xue X;Wu Y;Qiao Q;Zhong A;Xia X;Liao H;Wang Z;Zhang L
• 通讯作者: Zhang L

Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry.

使用热解气相色谱质谱法对人胎盘样本中微塑料积累进行定量和鉴定。

• DOI: 10.1093/toxsci/kfae021
• 发表时间: 2024
• 期刊: Toxicological sciences : an official journal of the Society of Toxicology
• 作者: Garcia,MarcusA;Liu,Rui;Nihart,Alex;ElHayek,Eliane;Castillo,Eliseo;Barrozo,EnricoR;Suter,MelissaA;Bleske,Barry;Scott,Justin;Forsythe,Kyle;Gonzalez-Estrella,Jorge;Aagaard,KjerstiM;Campen,MatthewJ
• 通讯作者: Campen,MatthewJ

Role of Nucleotide Excision Repair in Cisplatin Resistance.

• DOI: 10.3390/ijms21239248
• 发表时间: 2020-12-04
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Duan M;Ulibarri J;Liu KJ;Mao P
• 通讯作者: Mao P

Indirect mediators of systemic health outcomes following nanoparticle inhalation exposure.

• DOI: 10.1016/j.pharmthera.2022.108120
• 发表时间: 2022-07
• 期刊: PHARMACOLOGY & THERAPEUTICS
• 影响因子: 13.5
• 作者: Mostovenko, Ekaterina;Canal, Christopher G.;Cho, MiJin;Sharma, Kirti;Erdely, Aaron;Campen, Matthew J.;Ottens, Andrew K.
• 通讯作者: Ottens, Andrew K.