WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center

华盛顿大学-西北大学基因组变异和功能数据及行政协调中心

基本信息

批准号：
10631116
负责人：
Ting Wang
金额：
$ 157.76万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-24 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10631116
关键词：
Adopted Adoption Affect Bioinformatics Biological Assay Biology Books Catalogs Cells Communication Communities Community Outreach Computer Analysis Controlled Vocabulary Data Data Analyses Data Collection Data Set Databases Development Disease Documentation Educational Materials Educational workshop Ensure Environment Feedback Gene Expression Genes Genome Genomics Goals Housing Human Laboratories Lead Learning Maps Metadata Methods Modeling Mus Participant Pathway Analysis Periodicals Phenotype Population Process Production Progress Reports Protocols documentation Provider Public Health Quality Control Reporting Research Resources Series Shapes Specific qualifier value Speed Structure System Technology Testing Training Update Variant Vision Visualization Work Writing analysis pipeline biological research clinically significant complex data computerized tools data analysis pipeline data format data integration data mining data portal data resource data standards data visualization distributed data epigenome experience genome browser genome resource genomic data genomic variation human pangenome improved large datasets meetings member metadata standards novel operation outreach outreach program programs service organization symposium tool user-friendly verification and validation web portal webinar working group

项目摘要

PROJECT SUMMARY The goals of the WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center (IGVF-DACC) component of the IGVF Consortium are to collect, store, curate, and display all data, metadata, and analysis tools generated by the IGVF Consortium. The DACC will assist in developing and disseminating metadata and standards to be adopted by the community at large, approaches for integrative analysis of a wide range of data types, and visualization and analysis tools to facilitate access and understanding of complex datasets to non-expert users. Ultimately, the IGVF Consortium will produce tools, analyses, models, and data that form the catalog of variants and their functional impact. We will develop the DACC into a substantial service organization allowing scientific research to take full advantage of the IGVF reference catalog or map. To support the IGVF Consortium, we will establish databases with an application framework to facilitate complex data loading. We will include detailed experimental descriptions and metadata. We will define and develop pipelines that connect all Consortium members to the data and create avenues of access that distribute the data to the greater biological research community. We will establish metadata requirements, controlled vocabularies, standardized data formats, and quality control metrics for all IGVF data. We will bring together laboratories that generate complex data types via experimental assays with laboratories that integrate these data using computational tools to define the effects of genomic variation on genome function and how these effects shape phenotypes. By creating structures and data flow pipelines for the verification and validation of all data and providing processes for the documentation of metadata, the DACC will enhance the IGVF data production. The DACC will also coordinate integrative data analysis by creating and adapting analysis pipelines and developing advanced Genome Browser functions for the visual integration of IGVF data. Also, we will make the IGVF Web Portal that will be the primary entry point to the wealth of experimental data and computational analyses. The Portal will integrate these data resources and make them available via enhanced search and browsing capabilities. Finally, the DACC will provide documentation, training, and outreach via many media, including written documentation, video tutorials, online books, webinars, and meeting workshops and presentations.

项目概要华盛顿大学西北基因组变异和功能数据与管理的目标 IGVF 联盟的协调中心 (IGVF-DACC) 负责收集、存储、管理和展示 IGVF 联盟生成的所有数据、元数据和分析工具。 DACC 将协助开发传播元数据和供整个社区采用的标准、综合方法分析多种数据类型，并提供可视化和分析工具以方便访问和理解向非专家用户提供复杂的数据集。最终，IGVF 联盟将生产工具、分析、模型、以及构成变体目录及其功能影响的数据。我们将把DACC发展成为一个实质性的允许科学研究充分利用 IGVF 参考目录或地图的服务组织。到支持IGVF联盟，我们将建立带有应用程序框架的数据库，以方便复杂的数据加载。我们将包括详细的实验描述和元数据。我们将定义和开发将所有联盟成员连接到数据并创建分发数据的访问途径的管道到更大的生物研究界。我们将建立元数据要求、受控词汇、所有 IGVF 数据的标准化数据格式和质量控制指标。我们将汇集实验室通过实验室的实验分析生成复杂的数据类型，并使用这些数据集成定义基因组变异对基因组功能的影响以及这些影响如何形成的计算工具表型。通过创建结构和数据流管道来验证和验证所有数据和通过提供元数据记录流程，DACC 将增强 IGVF 数据生产。这 DACC 还将通过创建和调整分析管道以及开发来协调综合数据分析先进的基因组浏览器功能，用于 IGVF 数据的可视化集成。此外，我们还将制作 IGVF Web 该门户将成为丰富的实验数据和计算分析的主要入口点。这门户将整合这些数据资源，并通过增强的搜索和浏览提供它们能力。最后，DACC 将通过多种媒体提供文档、培训和宣传，包括书面文档、视频教程、在线书籍、网络研讨会以及会议研讨会和演示。