WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center

华盛顿大学-西北大学基因组变异和功能数据及行政协调中心

基本信息

批准号：
10631116
负责人：
Ting Wang
金额：
$ 157.76万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-24 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10631116
关键词：
Adopted Adoption Affect Bioinformatics Biological Assay Biology Books Catalogs Cells Communication Communities Community Outreach Computer Analysis Controlled Vocabulary Data Data Analyses Data Collection Data Set Databases Development Disease Documentation Educational Materials Educational workshop Ensure Environment Feedback Gene Expression Genes Genome Genomics Goals Housing Human Laboratories Lead Learning Maps Metadata Methods Modeling Mus Participant Pathway Analysis Periodicals Phenotype Population Process Production Progress Reports Protocols documentation Provider Public Health Quality Control Reporting Research Resources Series Shapes Specific qualifier value Speed Structure System Technology Testing Training Update Variant Vision Visualization Work Writing analysis pipeline biological research clinically significant complex data computerized tools data analysis pipeline data format data integration data mining data portal data resource data standards data visualization distributed data epigenome experience genome browser genome resource genomic data genomic variation human pangenome improved large datasets meetings member metadata standards novel operation outreach outreach program programs service organization symposium tool user-friendly verification and validation web portal webinar working group

Adopted Adoption Affect Bioinformatics Biological Assay Biology Books Catalogs Cells Communication Communities Community Outreach Computer Analysis Controlled Vocabulary Data Data Analyses Data Collection Data Set Databases Development Disease Documentation Educational Materials Educational workshop Ensure Environment Feedback Gene Expression Genes Genome Genomics Goals Housing Human Laboratories Lead Learning Maps Metadata Methods Modeling Mus Participant Pathway Analysis Periodicals Phenotype Population Process Production Progress Reports Protocols documentation Provider Public Health Quality Control Reporting Research Resources Series Shapes Specific qualifier value Speed Structure System Technology Testing Training Update Variant Vision Visualization Work Writing analysis pipeline biological research clinically significant complex data computerized tools data analysis pipeline data format data integration data mining data portal data resource data standards data visualization distributed data epigenome experience genome browser genome resource genomic data genomic variation human pangenome improved large datasets meetings member metadata standards novel operation outreach outreach program programs service organization symposium tool user-friendly verification and validation web portal webinar working group

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项目摘要

PROJECT SUMMARY The goals of the WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center (IGVF-DACC) component of the IGVF Consortium are to collect, store, curate, and display all data, metadata, and analysis tools generated by the IGVF Consortium. The DACC will assist in developing and disseminating metadata and standards to be adopted by the community at large, approaches for integrative analysis of a wide range of data types, and visualization and analysis tools to facilitate access and understanding of complex datasets to non-expert users. Ultimately, the IGVF Consortium will produce tools, analyses, models, and data that form the catalog of variants and their functional impact. We will develop the DACC into a substantial service organization allowing scientific research to take full advantage of the IGVF reference catalog or map. To support the IGVF Consortium, we will establish databases with an application framework to facilitate complex data loading. We will include detailed experimental descriptions and metadata. We will define and develop pipelines that connect all Consortium members to the data and create avenues of access that distribute the data to the greater biological research community. We will establish metadata requirements, controlled vocabularies, standardized data formats, and quality control metrics for all IGVF data. We will bring together laboratories that generate complex data types via experimental assays with laboratories that integrate these data using computational tools to define the effects of genomic variation on genome function and how these effects shape phenotypes. By creating structures and data flow pipelines for the verification and validation of all data and providing processes for the documentation of metadata, the DACC will enhance the IGVF data production. The DACC will also coordinate integrative data analysis by creating and adapting analysis pipelines and developing advanced Genome Browser functions for the visual integration of IGVF data. Also, we will make the IGVF Web Portal that will be the primary entry point to the wealth of experimental data and computational analyses. The Portal will integrate these data resources and make them available via enhanced search and browsing capabilities. Finally, the DACC will provide documentation, training, and outreach via many media, including written documentation, video tutorials, online books, webinars, and meeting workshops and presentations.

项目摘要 WASHU-NORTHWESTERN基因组变异和功能数据以及管理的目标 IGVF财团的协调中心（IGVF-DACC）组件将收集，存储，策展人和显示 IGVF联盟生成的所有数据，元数据和分析工具。 DACC将协助开发并传播元数据和整个社区采用的标准，分析广泛的数据类型以及可视化和分析工具，以促进访问和理解非专家用户的复杂数据集。最终，IGVF联盟将生产工具，分析，模型，以及构成变体目录及其功能影响的数据。我们将将DACC发展为实质性服务组织允许科学研究充分利用IGVF参考目录或地图。到支持IGVF财团，我们将建立具有应用程序框架的数据库，以促进复杂数据加载。我们将包括详细的实验描述和元数据。我们将定义和发展将所有财团成员连接到数据并创建分配数据的访问途径的管道到更大的生物学研究界。我们将建立元数据要求，受控词汇，所有IGVF数据的标准化数据格式和质量控制指标。我们将汇集实验室通过实验室使用实验室生成复杂的数据类型，这些实验室使用计算工具来定义基因组变异对基因组功能的影响以及这些影响如何形状表型。通过创建结构和数据流管道，以验证和验证所有数据以及为元数据的文档提供过程，DACC将增强IGVF数据生产。这 DACC还将通过创建和适应分析管道和开发来协调集成数据分析高级基因组浏览器功能，用于视觉整合IGVF数据。另外，我们将制作IGVF网络门户将成为大量实验数据和计算分析的主要切入点。这门户将集成这些数据资源，并通过增强搜索和浏览使其可用功能。最后，DACC将通过许多媒体提供文档，培训和推广，包括书面文档，视频教程，在线书籍，网络研讨会以及会议研讨会和演示文稿。