Polymeric matrix loaded with tick repellent or toxic compositions for incorporation into fabrics or for granular dispersal

负载有驱蜱剂或有毒组合物的聚合物基质，用于掺入织物或用于颗粒分散

• 批准号: 10547078
• 负责人: Michael Gilbert Banfield
• 金额: $ 92.87万
• 依托单位: BANFIELDBIO INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10547078
• 关键词: Adult; Ambylomma americanum; Area; Award; Bacteria; Behavior; Biological Assay; Black-legged Tick; Characteristics; Chemicals; Clothing; Cytoplasmic Granules; Data; Detection; Development; Dose; Ensure; Evaluation; Fiber; Filament; Formulation; Gait; Geographic Locations; Goals; Habitats; Human; Incidence; Insecticides; Journals; Laboratories; Legal patent; Longevity; Lyme Disease; Methods; Mus; Outcome; Paper; Participant; Pathway interactions; Peer Review; Permethrin; Persons; Pest Control; Phase; Poison; Polymers; Preventive treatment; Procedures; Production; Publications; Publishing; Resistance; Resistance development; Route; Site; Solvents; Statistical Data Interpretation; Technology; Technology Transfer; Testing; Textiles; Tick Control; Tick-Borne Diseases; Ticks; Toxic effect; Walking; Work; Writing; acaricide; base; climate change; commercialization; controlled release; design; efficacy evaluation; experimental study; global temperature; human disease; human pathogen; improved; laboratory experiment; meetings; novel; preference; prevent; prototype; pyrethroid; research and development; scale up; tick transmission; toxicant; vector

Project Summary/Abstract Within the US, ticks transmit 18 human pathogens, one of the most serious being Lyme disease, with an estimated 476,000 cases per year. Current tick management and human repellent and toxic products were designed either with protection against ticks as an “after-thought” or through the use of a pyrethroid insecticide to which ticks are increasingly developing resistance. There is also a current push by consumers to use natural and organic pest control products. As global temperatures rise, leading to a higher incidence of tick-borne diseases, there is a critical need for improved tick management products. This Phase II application will build on the development of novel polymeric microparticles as carriers of non-volatile acaricides by BanfieldBio for the DWFP award on “Murine autodissemination for long-term, area-wide control of ticks”. Based on encouraging preliminary evidence, we propose to adapt the polymeric microparticles to manufacture microporous polymeric granules and fibers that can be formulated to release volatile repellents and toxicants. Formulated granules would be used in landscape treatments to kill and repel ticks, and the fibers would be woven into outerwear fabrics to protect humans from acquiring and being bitten by ticks. Candidate active ingredients are nootkatone and 2-undecanone, which could be used alone or in combination with each other and/or permethrin. The project will target two species, blacklegged ticks and lone star ticks, both of which are important vectors of human disease, and will employ laboratory and field experimentation to explore and develop both types of formulation into novel prototype products. The proposed research and development would culminate in five potential outcomes: 1) a proprietary polymeric microporous granular composition formulated with one or more repellent and/or toxic compounds, 2) a demonstration that the formulated granular composition is effective against immature and adult ticks, and ready for scale-up, testing and development as a landscape-level tick preventive treatment, 3) fabric incorporating proprietary polymeric microporous filaments formulated with one or more repellent and/or toxic compounds, 4) demonstration that the fabric formulated with one or more repellent and/or toxic compounds is effective against immature and adult ticks, 5) fabric formulated with one or more repellent and/or toxic compounds manufactured into gaiters, and ready for technology transfer to commercial fabric production and incorporation into multiple types of outerwear clothing. As applicable, patent applications will be filed, the results published in peer-reviewed journals, and pathways to operational implementation and commercialization will be identified and exploited.

项目概要/摘要 在美国，蜱传播 18 种人类病原体，其中最严重的是莱姆病， 估计每年有 476,000 例蜱虫管理和人类驱避剂和有毒产品。 作为“事后考虑”或通过使用拟除虫菊酯杀虫剂来设计以防止蜱虫 蜱虫对这种物质的抵抗力日益增强。目前消费者也正在推动使用天然物质。 随着全球气温上升，蜱传疾病的发病率更高。 疾病，迫切需要改进蜱虫管理产品，该二期应用将建立在其基础上。 BanfieldBio 开发了新型聚合物微粒作为非挥发性杀螨剂载体 DWFP 授予“通过小鼠自身传播实现蜱虫长期、大范围控制”的奖项，令人鼓舞。 初步证据表明，我们建议采用聚合物微粒来制造微孔 聚合物颗粒和纤维，可配制以释放挥发性驱虫剂和毒物。 颗粒将用于景观处理以杀死和驱除蜱虫，纤维将被编织成 保护人类免受蜱虫叮咬的外衣面料是候选活性成分。 nootkatone 和 2-十一酮，它们可以单独使用或彼此组合使用和/或 该项目将针对两种蜱虫：黑腿蜱虫和孤星蜱虫。 人类疾病的重要载体，并将利用实验室和现场实验来探索和 将两种类型的配方开发成新颖的原型产品。 拟议的研究和开发最终将产生五个潜在成果：1）专有技术 用一种或多种驱虫剂和/或有毒化合物配制的聚合物微孔颗粒组合物， 2) 证明配制的颗粒组合物对未成熟和成年蜱有效，并且 准备好作为景观级蜱虫预防处理进行放大、测试和开发，3) 织物 结合了由一种或多种驱虫剂和/或有毒剂配制而成的专有聚合物微孔长丝 化合物，4) 证明含有一种或多种驱虫剂和/或有毒化合物的织物配方是 有效对抗幼蜱和成年蜱，5) 用一种或多种驱虫剂和/或有毒剂配制的织物 化合物制造成护腿，并准备好将技术转移到商业织物生产和 融入多种类型的外套服装中。 在适用的情况下，将提交专利申请，在同行评审的期刊上发表结果，以及途径 将确定和利用业务实施和商业化。