Kissing bug kill trap for control of Trypanosoma cruzi infection

用于控制克氏锥虫感染的接吻虫杀灭陷阱

• 批准号: 10493292
• 负责人: Michael Gilbert Banfield
• 金额: $ 16.75万
• 依托单位: TEXAS A&M AGRILIFE RESEARCH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10493292
• 关键词: Abate; Adult; Americas; Arthropods; Behavioral; Biological Assay; Biology; Blood donor screening; Chagas Disease; Data; Development; Disease; Ensure; Environment; Exposure to; Future; Guatemala; Habitats; Hemiptera; Human; Individual; Infection; Insect Vectors; Insecta; Insecticide Resistance; Intercept; Light; Maintenance; Manuals; Parasites; Pattern; Persons; Pharmaceutical Preparations; Pheromone; Population; Protocols documentation; Reduviidae; Research; Residual state; Risk; Risk Reduction; Sampling; Specimen; Standardization; Testing; Texas; Trypanosoma cruzi; Vaccines; Variant; citizen science; commercialization; cost effective; disorder control; disorder risk; expectation; experimental study; exposed human population; field study; improved; neglected tropical diseases; preservation; prevent; programs; prototype; spatiotemporal; tool; tool development; transmission process; vector; vector control; vector-borne

Project Summary Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, transmitted by triatomine ‘kissing bug’ insects. An estimated 6 million people are infected worldwide, including 240,000 to 350,000 people in the U.S., and WHO identifies Chagas disease as one of four Neglected Tropical Diseases that does not have a cost-effective control tool. Disease control relies heavily on reducing insect vectors although very few programs have allowed for sustainable solutions that prevent spill-over of kissing bugs from sylvatic habitats to re-colonize the domestic environment. This study will develop a kissing bug kill trap which autonomously captures, kills, and preserves the insect vectors of T. cruzi. Building on two years of field trials testing prior prototypes, this project will conduct behavioral bioassays with captive kissing bugs to identify LED light wavelengths with maximum attraction. We will also conduct two years of field experiments evaluating different LED light and reflective and fluorescing trap materials which will synergistically optimize the capture of kissing bugs while minimizing non-target bycatch. These field studies will be in Texas and Guatemala to ensure trap efficacy for multiple species of kissing bugs that are primary vectors in the Americas. The development of this standardized tool will allow for future large-scale surveillance to quantify spatio-temporal variation in kissing bugs. This tool that captures and kills dispersing adult kissing bugs will also permit future studies integrating this mass-trapping approach along with existing vector control tools to reduce human risk of exposure to T. cruzi.

项目摘要 查加斯病是由原生动物寄生虫锥虫克鲁兹引起的，由 三位一体的“亲吻虫”昆虫。 美国240,000至350,000人，识别chagas病是四个 没有具有成本效益的控制工具的被忽视的热带疾病 严重依赖于减少昆虫媒介的Allooth很少允许的程序 可持续的解决方案，这些解决方案溢出了从sylvatic栖息地重新殖民的接吻虫子 本研究将开发一个亲吻的虫子陷阱 捕获，杀死和保留T. Cruzi的昆虫载体。 测试先前的原型，该项目带有圈养的亲吻错误 为了确定具有最大吸引力的LED光波长。 评估不同LED光以及反射性和荧光陷阱材料的现场实验 在最小化非目标的同时，它将协同优化接吻错误的捕获 这些现场研究将在德克萨斯州和危地马拉 亲吻虫子是美洲的主要媒介。 标准化工具将允许将来的大规模监视来量化时空 接吻虫子的变化。 允许将来的研究将这种大众捕获与现有矢量控制结合在一起 降低人类暴露于T. Cruzi的风险的工具。