Development of an autodissemination station for control of mosquito vectors

开发用于控制蚊媒的自动传播站

基本信息

批准号：
8253634
负责人：
Michael Gilbert Banfield
金额：
$ 14.99万
依托单位：
BANFIELDBIO INC.
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2012-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8253634
关键词：
Adult Aedes Animals Area Behavior Biodegradation Biological Assay Biology Bite Breeding Collection Critical Pathways Culicidae Data Analyses Dengue Deposition Development Devices Disease Dose Drug Formulations Environment Environmental Risk Factor Evaluation Exhibits Female Fogs Funding Government Agencies Habitats Health Hormonal Human Industry Insect Control Insecta Insecticides Instinct Juvenile Hormones Laboratory Study Lead Life Maintenance Methods Military Personnel Molds Mosquito Control Oviposition Patient currently pregnant Phase Population Population Control Powder dose form Production Protocols documentation Public Health Recommendation Research Resistance development Sales Series Site Source Sum Techniques Technology Testing Trees Vertebrates Visit Water West Nile virus Writing Yellow Fever chikungunya cost cost effective design disease transmission egg improved interest meetings minimal risk novel pathogen prototype tool toxicant vector vector control vector mosquito

项目摘要

DESCRIPTION (provided by applicant): Autodissemination is a novel technique for insect control whereby target insects spread insecticide to their own habitats through their innate behaviors: a small treatment area results in far wider and target-specific coverage. This concept shows high potential for improved control of urban container-breeding mosquitoes, many of which vector deadly or debilitating diseases, such as dengue, Chikungunya and yellow fever, and also hamper outdoor activity through incessant biting behaviors. These peridomestic mosquitoes are problematic to manage with the aerial spray and fogging regimes typically used by vector control. As container-breeding mosquitoes continue to expand their distribution, dengue and other mosquito-borne pathogens have risen globally. It is imperative that new tools be explored to suppress vector populations and mitigate disease transmission at a landscape level. This project evaluates the feasibility of using autodissemination in a novel device for operational mosquito control against both Aedes albopictus and Aedes aegypti. Prototype autodissemination devices, or "stations," will be conceived, designed and evaluated for control of Ae. aegypti and Ae. albopictus, container-breeding vector species now infesting all non-Antarctic continents. As they seek small containers in which to lay their eggs, gravid female mosquitoes will visit the stations and pick up a powdered material containing an insect growth regulator (IGR). Insect growth regulators specifically target the hormonal pathways critical to insect development and are essentially non-toxic to vertebrates. The target mosquito species exhibit what is known as "skip oviposition," meaning that they deposit eggs from a single clutch in multiple containers. That "skipping" behavior increases the likelihood that females visiting the station will subsequently visit other breeding sites, such as tree holes or buckets, and inoculate the water in those areas with tiny, but lethal doses of the IGR. All immature mosquitoes in those treated sites will not become viable adults capable of vectoring disease. To maximize field efficacy and minimize the labor and costs involved in use, features of the ideal final design will include: zero maintenance once deployed; low cost; full biodegradability; high attraction to the target mosquitoes; extended water retention and attraction through dry periods; high toxicant loading on visiting mosquitoes; and low environmental risk. Prototype stations and IGR formulations will be tested against live mosquitoes to optimize attractancy, water retention, field durability, extended efficacy, and transfer to and from mosquitoes. High potential candidate designs will be evaluated in small cage (1m3) bioassays to validate transfer between the station and other breeding containers via the mosquitoes. Autodissemination from the final prototype will be tested in replicated room (35m3) bioassays. The final prototype will be suitable for large- scale field testing in Phase II in a cooperative project with the Rutgers Center for Vector Biology PUBLIC HEALTH RELEVANCE: The proposed research will evaluate a simple, low-cost device with high potential to control populations of container-breeding mosquitoes worldwide, thereby lessening a global disease threat and outdoor nuisance. This device will provide a novel and highly-effective means to target the primary vectors of dengue fever, Chikungunya and West Nile virus and be suitable for cost-effective use around the globe with minimal risk to human beings, non-target animals or the surrounding environment.

描述（由申请人提供）：自动启示是一种新型的昆虫控制技术，靶向昆虫通过其先天行为将杀虫剂传播到自己的栖息地：一个小的治疗区域导致较宽和目标特定的覆盖范围。这个概念表明，改善了对城市容器繁殖蚊子的控制的潜力很高，其中许多媒介致命或使人衰弱的疾病（例如登革热，基孔肯亚和黄热病）以及不断咬人的行为来阻碍户外活动。通过媒介控制通常使用的空中喷雾剂和雾化状态来管理这些植物蚊子是有问题的。随着集装箱繁殖的蚊子继续扩大其分布，登革热和其他蚊子 - 传播的病原体在全球范围内都增加了。必须探索新工具以抑制媒介种群并在景观水平上减轻疾病的传播。该项目评估了在新型设备中使用自动污染的可行性，以对抗Aldes Aldopictus和Aedes Aegypti进行操作蚊子控制。原型自动发电设备或“站点”将被构想，设计和评估以控制AE。埃及和ae。白化病，容器繁殖的载体物种现在侵扰了所有非抗抗原大陆。当他们寻找产卵的小容器时，妊娠媒体将参观车站，并捡起含有昆虫生长调节剂（IGR）的粉末状材料。昆虫生长调节剂专门针对对昆虫发育至关重要的激素途径，对脊椎动物根本上是无毒的。目标蚊子物种表现出所谓的“跳过卵形”，这意味着它们从单个离合器中沉积了多个容器中的鸡蛋。这种“跳过”行为增加了女性访问的可能性车站随后将参观其他繁殖地，例如树洞或水桶，并以微小但致命的IGR剂量接种水。在那些经过治疗的地点中的所有未成熟蚊子都不会成为能够矢量疾病的成年人。为了最大化现场功效并最大程度地减少使用中涉及的人工和成本，理想最终设计的功能将包括：部署后零维护；低成本;完整的生物降解性；高吸引目标蚊子；通过干燥时期延长保留水分和吸引力；在来访的蚊子上负载高毒物；和低环境风险。原型站和IGR配方将针对活蚊子进行测试，以优化吸引力，保留水，场地耐用性，扩展功效以及从蚊子转移。高潜在的候选设计将在小笼子（1M3）的生物测定中进行评估，以通过蚊子在车站和其他繁殖容器之间进行验证。最终原型的自动隔离将在复制的房间（35m3）生物测定中进行测试。最终原型将适用于大型与罗格斯媒介生物学中心的合作项目中的II期比例现场测试公共卫生相关性：拟议的研究将评估一种简单，低成本的装置，具有控制全球容器繁殖蚊子种群的高潜力，从而减少了全球疾病威胁和室外滋扰。该设备将提供一种新颖且高效的手段，以针对登革热，基孔肯雅和西尼罗河病毒的主要向量，并适合在全球范围内具有成本效益环境。