HIV Clinical Tumor Biorepository

HIV临床肿瘤生物样本库

• 批准号: 10664027
• 负责人: Suki Subbiah
• 金额: $ 11.65万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664027
• 关键词: Academic Medical Centers; Acquired Immunodeficiency Syndrome; Address; Advisory Committees; Affect; African American; Ambulatory Care Facilities; Area; Articulation; Cancer Center; Cancer Diagnostics; Caring; Centers of Research Excellence; Characteristics; Clinic; Clinical; Clinical Data; Clinical Research; Collaborations; Collection; Communicable Diseases; Cytotoxic Chemotherapy; Data; Diagnosis; Drug Interactions; Drug resistance; Economics; Enrollment; Ensure; Environment; Epidemic; Ethics; Ethnic Origin; Funding; Genes; Genetic; Goals; Grant; HIV; HIV therapy; HIV-1; HIV/AIDS; Health; Healthcare Systems; Human; Human Resources; Immunologics; Incidence; Individual; Infection; Institution; Laboratories; Link; Louisiana; Malignant Neoplasms; Minority; Minority Groups; Neoplasms; Oncogenic Viruses; Oncology; Outcome; Patients; Performance; Persons; Pharmaceutical Preparations; Phase; Phenotype; Population; Positioning Attribute; Principal Investigator; Privacy; Public Health Schools; Research; Risk; Sampling; Services; System; Therapeutic; Toxic effect; Translational Research; Update; Viral; Viral Cancer; Virus; Virus Latency; Wood material; Work; anticancer research; biobank; biomedical referral center; cancer care; clinical translation; clinically relevant; co-infection; cost; epidemiologic data; health disparity; high risk; human subject protection; immune modulating agents; improved; minority health disparity; mortality; patient population; preference; programs; social; standard of care; stemness; tumor; tumor registry; underserved minority; virus related cancer; volunteer

Abstract: The HCTB Core will assist Junior Principal Investigators (JPIs) with the application of their promising research to the field of clinical viral oncology through prioritization of clinical data and biospecimen collection for JPIs in Phase 2 of Center for Translational Viral Oncology (CTVO). The CTVO will support personnel in the Core who will provide services to the JPIs at reduced/no cost. Consistent with the articulated theme of Phase 2 CTVO, the HCTB, organized and directed by Drs. Subbiah and Bonstaff, collects biospecimens from the HIV/AIDS Malignancy Program and from other oncology clinics that evaluate, diagnose and treat patients with viral associated malignancies. These patients are disproportionately minorities, mostly African American. The overarching goal of HCTB is to assist JPIs with performance of high-quality translational research utilizing linked biospecimens and clinical data from patients receiving care at the University Medical Center - Infectious Diseases Center (UMCNO-IDC) and its affiliated partner, HIV/AIDS Malignancy Program. Use of de-identified human samples will inform and ensure clinical relevance of mechanistic studies and promote clinical translation. Through this effort, we seek to improve health outcomes for underserved HIV+ patients at risk for virus-associated cancers. In addition, access to these unique samples provides JPI's with a competitive edge as they apply for independent grant funding. The HCTB Core will support proposed by JPI research through the following Specific Aims: 1) To expand a HIV outpatient clinic-based system for collection of linked clinical data and biospecimens from HIV+ patients in New Orleans who are at high risk for virus-associated cancers; 2) To ensure storage of high-quality HIV+ biospecimens for easy access by JPIs; 3) To perform timely delivery/shipment of HIV+ biospecimens to internal and external collaborators; 4) To promote collaboration between JPIs and the staff of the Louisiana Tumor Registry (LTR) at LSU School of Public Health to provide access to updated epidemiologic data and analyses on the distribution of viral tumors in underserved minority populations in our State. Funding to the CTVO will support personnel employed within the Core and allow services to be provided at reduced cost to the JPIs while also providing for institutional ethical compliance and insuring protection of human subjects and their privacy. Leveraging involvement of several Centers and Programs at LSUHSC ensures ongoing support and function of this Core following conclusion of the COBRE funding.

摘要：HCTB核心将协助初级首席调查员（JPIS）的应用 通过优先考虑临床数据和生物测定的优先考虑，对临床病毒肿瘤学领域有希望的研究 JPI在转化病毒肿瘤学中心（CTVO）的2阶段收集。 CTVO将支持 核心人员将以减少/无费用为JPI提供服务。与表达的 第2阶段CTVO，HCTB的主题，由DRS组织和导演。 Subbiah和Bonstaff，收集 来自艾滋病毒/艾滋病恶性计划和其他评估的肿瘤学诊所的生物测量 诊断和治疗病毒相关的恶性肿瘤患者。这些患者不成比例 少数民族，主要是非裔美国人。 HCTB的总体目标是协助JPI的性能 利用链接的生物测量和接受护理患者的临床数据的高质量转化研究 在大学医学中心 - 传染病中心（UMCNO -IDC）及其附属合作伙伴 艾滋病毒/艾滋病恶性计划。使用被取消识别的人类样本将告知并确保临床相关性 机械研究并促进临床翻译。通过这项努力，我们试图改善健康 服务不足的艾滋病毒+患者的结局有与病毒相关的癌症的风险。此外，访问这些 独特的样本为JPI提供了竞争优势，因为它们申请了独立的赠款资金。这 HCTB核心将支持JPI研究提出的通过以下特定目的：1）扩大艾滋病毒 基于门诊的基于诊所的系统，用于收集艾滋病毒+患者的链接临床数据和生物测量 与病毒相关癌症高风险的新奥尔良； 2）确保存储高质量的艾滋病毒+ 生物测量，可轻松访问JPI； 3）及时进行艾滋病毒+生物测量的运送/发货 内部和外部合作者； 4）促进JPI与路易斯安那州工作人员之间的合作 路易斯安那州立公共卫生学院的肿瘤注册表（LTR）提供更新的流行病学数据和 对我们州服务不足的少数群体中病毒肿瘤分布的分析。资金给 CTVO将支持核心内部使用的人员，并允许以降低成本提供服务 JPI同时还提供了制度的道德合规性并确保对人类受试者的保护 和他们的隐私。利用LSUHSC的几个中心和计划的参与可确保持续 在毛绒资金结束后，该核心的支持和功能。