Neuroscience Training Program

神经科学培训计划

基本信息

批准号：
10665578
负责人：
Daniel T. Tranel
金额：
$ 28.57万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-07-09 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10665578
关键词：
Neurosciences Training Programs

项目摘要

Project Summary/Abstract This renewal application requests support for integrated, broad-based, fundamental, multidisciplinary predoctoral training of first- and second-year students in Neuroscience at the University of Iowa. The application builds on more than three decades of success in matriculating, training, and placing top-caliber PhD students. Our Program features mature leadership (enhanced by the addition of an Associate Director), a sustained 10-year increase in the quality, depth, diversity, and geographic breadth of our applicant pool, and a sharp recent increase in funded neuroscience faculty. The Program draws on a long tradition of collaborations between basic and clinical scientists and a strong translational focus. Institutional support is exceptional. The Training Faculty are 52 experienced, well-funded neuroscientists with research interests that span the gamut of neuroscience, and 20 preceptors are clinician-scientists. Students participate in a carefully honed curriculum that offers broad and fundamental training in levels of analysis and diversity of approaches, with a special focus on the neuroscience of disease and disorders (including a very successful Neurobiology of Disease course). There is intensive training in experimental design, statistical methodology, and quantitative skills and literacy (enhanced by a new required course in Advanced Quantitative Training) and in professional skills development (enhanced by new curricular components in teaching, oral/written communication, networking/skill building, and grantsmanship), and detailed annual evaluation using the Individual Developmental Plan. The Program incorporates three laboratory rotations, regular programmatic activities (Seminar, Research Day, journal clubs), and comprehensive training in responsible conduct of research. The “value-added” is especially compelling—NIH training grant dollars enhance every aspect of our Program and have contributed directly to sustained successes marked by outstanding time to degree (20-year average of 5.2 years), productivity (5.1 publications per student, 2.9 as first author), completion rate (around 80%), placement of graduates in stellar neuroscience careers (over the past two decades, 51% of our graduates are in tenured or tenure-track academic positions), and diversity accomplishments (some 33% of our current student cohort is diverse; one-third [30/91] of our matriculated students over the past 10 years are diverse; these students have outstanding completion and placement outcomes). To maintain and extend these accomplishments, this renewal request asks for 8 slots per year to support first- and second-year students.

项目概要/摘要此更新申请要求支持综合的、基础广泛的、基础的、多学科的爱荷华大学神经科学专业一年级和二年级学生的博士前培训。申请建立在三十多年来在入学、培训和安置顶尖人才方面取得的成功基础上我们的项目具有成熟的领导力（通过增加副主任来增强）、我们的申请人库的质量、深度、多样性和地理广度持续了 10 年的增长，并且最近受资助的神经科学教师人数急剧增加，该计划借鉴了悠久的合作传统。基础科学家和临床科学家之间的合作以及强有力的转化关注是非常出色的。培训教师由 52 名经验丰富、资金雄厚的神经科学家组成，他们的研究兴趣涵盖各个领域神经科学，20 名导师是临床科学家，学生参加精心设计的课程。它提供了分析水平和方法多样性方面的广泛和基础的培训，并具有特殊的专注于疾病和失调的神经科学（包括非常成功的疾病神经生物学课程）有实验设计、统计方法和定量技能方面的强化培训。读写能力（通过高级定量培训的新必修课程增强）和专业技能发展（通过教学中的新课程内容、口头/书面交流、网络/技能建设和资助），以及使用个人的详细年度评估该计划包括三个实验室轮换和定期计划活动。（研讨会、研究日、期刊俱乐部）以及负责任的研究行为的综合培训。 “增值”尤其引人注目——NIH 培训补助金增强了我们计划的各个方面，直接为持续成功做出了贡献，其特点是出色的学位时间（20年平均 5.2 年）、生产率（每个学生 5.1 篇出版物，作为第一作者 2.9 篇）、完成率（约 80%）、将毕业生安置在出色的神经科学职业中（在过去二十年中，我们 51% 的毕业生终身教职或终身教职学术职位）和多样性成就（我们目前的约 33%）学生群体是多元化的；过去 10 年，我们录取的学生中有三分之一 [30/91] 是多元化的；这些学生具有出色的完成和安置成绩）。完成后，此更新请求要求每年提供 8 个名额来支持一年级和二年级学生。

项目成果

期刊论文数量（25）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Free-running circadian breathing rhythms are eliminated by suprachiasmatic nucleus lesion.

自由运行的昼夜呼吸节律被视交叉上核病变消除。

DOI：
10.1152/japplphysiol.00211.2020
发表时间：
2020
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
0
作者：
Purnell,BentonS;Buchanan,GordonF
通讯作者：
Buchanan,GordonF

Dorsal Raphe Serotonin Neurons Mediate CO2-Induced Arousal from Sleep.

中缝背侧血清素神经元介导二氧化碳诱导的睡眠唤醒。

DOI：
10.1523/jneurosci.2182-17.2018
发表时间：
2018
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Smith,HaleighR;Leibold,NicoleK;Rappoport,DanielA;Ginapp,CallieM;Purnell,BentonS;Bode,NicoleM;Alberico,StephanieL;Kim,Young-Cho;Audero,Enrica;Gross,CorneliusT;Buchanan,GordonF
通讯作者：
Buchanan,GordonF

Splicing of an automodulatory domain in Cav1.4 Ca2+ channels confers distinct regulation by calmodulin.

Cav1.4 Ca2 通道中自调节结构域的剪接赋予钙调蛋白独特的调节作用。