Novel molecular and cellular approaches for alcoholism medication development

酒精中毒药物开发的新分子和细胞方法

• 批准号: 8843309
• 负责人: Robert A Harris
• 金额: $ 66.43万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-04 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8843309
• 关键词: Affect; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Animal Model; Animals; Behavior; Binding; Brain; Collaborations; DNA; DNA Methylation; Data; Development; Drug Addiction; Electrophysiology (science); Enzyme Inhibitor Drugs; Enzyme Inhibitors; Epigenetic Process; Ethanol; Funding; Gene Expression; Gene Expression Profile; Genes; Genetic Transcription; Glycine Receptors; Goals; Histone Acetylation; Histone Deacetylation; Human; Ion Channel; Knowledge; Ligands; Measures; MicroRNAs; Molecular; Molecular Biology; Molecular Target; Mus; Neurobiology; Peptides; Phage Display; Pharmaceutical Preparations; Program Research Project Grants; Proteins; Regulator Genes; Research; Research Personnel; Research Project Grants; Scientist; Site; Techniques; Technology; Testing; Therapeutic; Translating; Translations; alcohol research; alcohol reward; alcoholism therapy; behavior test; design; drug development; experience; inhibitor/antagonist; innovation; member; new therapeutic target; novel; problem drinker; programs; therapy development

This five-year funding proposal for a Program Project Grant on alcohol-related research provides innovative paradigms for medication development for the treatment of alcoholism by bringing together experienced alcohol researchers with expertise in molecular biology, electrophysiology and behavior. The goal is to develop the technologies and collaborations necessary to define new targets for medication development and translate our knowledge of alcohol targets into selective ligands. The PPG consists of an Administrative Core (Adron Harris, PI and Center Director), identification and characterization of specific allosteric modulators of ion channels using phage display (S. John Mihic and Rick Morrisett), molecular and cellular mechanisms of novel therapeutic targets in alcohol reward (Igor Ponomarev and Hitoshi Morikawa), microRNA targets for medication development (Dayne Mayfield) and an animal core (Yuri Blednov and Rueben Gonzales) to provide mice and behavioral testing to the projects. The PPG has both internal and external advisory board members, providing expert guidance from scientists with a wide range of expertise in drug development and therapeutics.

这项为期五年的酒精相关研究计划项目拨款提案，通过汇集具有分子生物学、电生理学和行为学专业知识的经验丰富的酒精研究人员，为治疗酒精中毒的药物开发提供了创新范例。目标是开发必要的技术和合作来定义药物开发的新靶点，并将我们对酒精靶点的知识转化为选择性配体。 PPG 包括一个行政核心（Adron Harris，PI 和中心主任）、使用噬菌体展示对离子通道的特定变构调节剂进行鉴定和表征（S. John Mihic 和 Rick Morrisett）、酒精中新型治疗靶点的分子和细胞机制奖励（Igor Ponomarev 和 Hitoshi Morikawa）、用于药物开发的 microRNA 靶标（Dayne Mayfield）和动物核心（Yuri Blednov 和 Rueben Gonzales），以提供小鼠和行为对项目进行测试。 PPG 拥有内部和外部顾问委员会成员，由在药物开发和治疗学方面拥有广泛专业知识的科学家提供专家指导。