Training Grant: Functional Protemics of Aging

培训补助金：衰老的功能蛋白质学

• 批准号: 8850365
• 负责人: Deborah Ann Ferrington
• 金额: $ 28.26万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8850365
• 关键词: Aging; Grant; Training

DESCRIPTION (provided by applicant): A group of investigators at the University of Minnesota seeks to renew "Functional Proteomics of Aging", an interdisciplinary Training Program that supports 4 predoctoral and 4 postdoctoral trainees. Program faculty members draw trainees from four graduate programs at the University of Minnesota: Biochemistry, Molecular Biology and Biophysics (BMBB), Rehabilitation Sciences (RSc), Neuroscience (NSc), and Chemistry (Chem). This Training Program contains two major components: (1) Research training that focuses on the use of proteomic technology to reveal the molecular details behind the age-related loss in tissue function and/or age-related disease. (2) Didactic and experiential training in gerontology and proteomics to provide trainees with a solid foundation for launching successful careers in aging research. The research component consists of three research areas that focus on retaining physiological function during aging or understanding disease mechanism: muscle (Ervasti, Lowe, Metzger, Thomas, Thompson), the central nervous system (Ferrington, Li, Low) and energy metabolism and longevity (Arriaga, Bernlohr, Griffin, Hendrickson, Kim). While these areas are broad in scope, they are thematically related through a shared interest in proteomics and aging. Proteomic analysis is utilized by Training faculty to reveal altered protein content, binding partners, and post-translational modifications that occur in aged tissue. This information aids in determining the mechanistic basis for age- and disease-related changes in protein structure and function. Our research is supported by outstanding cores equipped with a variety of state-of-the-art mass spectrometers in the Center for Mass Spectrometry and Proteomics and bioinformatics platforms in the Minnesota Supercomputers Institute. Training faculty laboratories also contain specialized analytical equipment that is commonly shared between Program faculty. This has helped foster extensive interdisciplinary collaborations among faculty and trainees. The Training Program also includes both didactic training via coursework in gerontology and proteomics, as well as experiential training in aging research via conferences, seminars, symposia, journal clubs, and group meetings with Program faculty members. The experiential training is designed to maximize interaction among trainees and Training faculty from multiple labs and with scientists outside the U of MN. In summary, the primary goal of this Training Program is to help exceptional young scientists develop the intellectual and technical tools needed for productive careers as independent investigators and educators in aging research.

描述（由申请人提供）：明尼苏达大学的一组研究人员寻求更新“衰老功能蛋白质组学”，这是一个跨学科培训项目，为 4 名博士前培训生和 4 名博士后培训生提供支持。该项目的教员从明尼苏达大学的四个研究生项目中招收学员：生物化学、分子生物学和生物物理学（BMBB）、康复科学（RSc）、神经科学（NSc）和化学（Chem）。该培训计划包含两个主要组成部分：(1) 研究培训，重点是使用蛋白质组技术来揭示与年龄相关的组织功能丧失和/或与年龄相关的疾病背后的分子细节。 (2) 老年学和蛋白质组学方面的教学式和体验式培训，为学员在衰老研究领域的成功职业生涯提供坚实的基础。研究部分由三个研究领域组成，重点是在衰老过程中保留生理功能或了解疾病机制：肌肉（Ervasti、Lowe、Metzger、Thomas、Thompson）、中枢神经系统（Ferrington、Li、Low）以及能量代谢和长寿（阿里亚加、伯恩洛尔、格里芬、亨德里克森、金）。虽然这些领域范围广泛，但它们在主题上通过对蛋白质组学和衰老的共同兴趣而相关。培训人员利用蛋白质组学分析来揭示老化组织中蛋白质含量、结合伙伴和翻译后修饰的变化。这些信息有助于确定与年龄和疾病相关的蛋白质结构和功能变化的机制基础。我们的研究得到了明尼苏达超级计算机研究所的质谱和蛋白质组学中心以及生物信息学平台配备各种最先进的质谱仪的杰出核心的支持。培训教员实验室还包含项目教员之间共同共享的专业分析设备。这有助于促进教师和学员之间广泛的跨学科合作。培训计划还包括通过老年学和蛋白质组学课程进行的教学培训，以及通过会议、研讨会、座谈会、期刊俱乐部和与计划教员举行的小组会议进行的衰老研究体验式培训。体验式培训旨在最大限度地促进来自多个实验室的学员和培训教师之间以及与明尼苏达大学以外的科学家之间的互动。总之，该培训计划的主要目标是帮助杰出的年轻科学家开发作为衰老研究的独立调查员和教育者的富有成效的职业所需的知识和技术工具。