REC Core

记录核心

• 批准号: 10663253
• 负责人: Laura D. Baker
• 金额: $ 10.79万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663253
• 关键词: Action Research; Address; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Award; Basic Science; Biological Markers; Brain imaging; Capsicum; Clinical; Clinical Sciences; Cognitive aging; Collaborations; Competence; Development; Discipline; Diverse Workforce; Education; Educational Curriculum; Educational workshop; Elderly; Ensure; Etiology; Faculty; Fostering; Foundations; Funding; Geriatrics; Gerontology; Goals; Grant; Image Analysis; Institution; Journals; Knowledge; Leadership; Measurement; Mentors; Mentorship; Metabolic; Modeling; Multi-site clinical study; Pathogenesis; Pathologic; Postdoctoral Fellow; Prevention; Principal Investigator; Recording of previous events; Research; Research Personnel; Research Project Summaries; Resources; Rodent; Scholars Program; Science; Scientist; Training; Training Programs; Training Support; Training and Education; Translational Research; Underrepresented Populations; United States National Institutes of Health; Work; Writing; career; career development; cognitive testing; education research; experience; faculty research; forest; graduate school; graduate student; healthy aging; instructor; interest; member; mid-career faculty; mild cognitive impairment; multidisciplinary; next generation; nonhuman primate; professor; programs; recruit; research and development; skills; student training; symposium; synergism; translational impact; undergraduate student; vascular risk factor

Research Education Component – Project Summary The Research Education Component will collaborate with other ADRC Cores and affiliate members to provide critical training and education to build a pipeline of new investigators from diverse backgrounds and with the necessary research interests and skills to meaningfully contribute to ADRD research – particularly with regard to metabolic and vascular risk factors underlying ADRD pathogenesis. In the last 4 years, we supported training of 20 graduate students and 8 postdoctoral fellows, and intensive mentoring for 17 junior faculty – 70% of whom now serve as Principal Investigators on 22 NIH or foundation ADRD grants. In the next cycle, REC programs will continue to leverage unique strengths and resources of the institution and the ADRC, particularly with regard to our experiences conducting ADRD translational research – from cellular mechanisms through rodent and nonhuman primate models to large-scale multi-site clinical studies. The REC Scholars Program will provide individualized and comprehensive training to junior investigators with clinical or basic science expertise to facilitate expansion of their work to support key concepts in translational science that could be instrumental in identifying effective strategies for ADRD prevention and treatment. The REC will also develop and deliver an extensive portfolio of ADRD-related educational programming for undergraduates, graduate students, fellows, and investigators from other disciplines to further expand the new investigator pipeline through ADRC interactions with Pepper OAIC, CTSI and other institutional programs. Given Wake Forest’s well-known and successful history conducting large multi-site clinical studies in older adults, a focus of the REC training program will include Team Science to provide new investigators with the skills to ensure successful project management, development of strong and sustainable collaborations, and effective leadership of multidisciplinary teams. Such teams will be essential for scientific discovery targeting prevention and treatment of ADRDs, which are characteristically heterogeneous in clinical presentation, etiology, and pathologic trajectory.

研究教育部分——项目摘要 研究教育部分将与其他 ADRC 核心和附属成员合作，提供 关键的培训和教育，以建立来自不同背景的新调查人员的管道，并与 为 ADRD 研究做出有意义的贡献所必需的研究兴趣和技能——特别是在以下方面 在过去 4 年中，我们支持 ADRD 发病机制的代谢和血管危险因素。 培养 20 名研究生和 8 名博士后，并为 17 名初级教师提供强化指导 – 70% 其中 22 人现在担任 22 项 NIH 或基金会 ADRD 资助的首席研究员。 项目将继续利用该机构和 ADRC 的独特优势和资源，特别是 关于我们进行 ADRD 转化研究的经验 - 从细胞机制到 REC 学者计划将啮齿动物和非人类灵长类动物模型进行大规模多地点临床研究。 为具有临床或基础科学专业知识的初级研究者提供个性化和全面的培训 促进扩大他们的工作，以支持可能有用的转化科学中的关键概念 REC 还将制定并提供 ADRD 预防、识别和治疗的有效策略。 为本科生、研究生、研究员提供广泛的 ADRD 相关教育项目组合， 和其他学科的研究人员通过 ADRC 进一步扩大新的研究人员渠道 与 Pepper OAIC、CTSI 和其他机构项目的互动。 在老年人中进行大型多中心临床研究的成功历史，这是 REC 培训的重点 计划将包括团队科学，为新研究人员提供确保项目成功的技能 管理、发展强有力和可持续的合作以及有效的领导 多学科团队对于针对预防和治疗的科学发现至关重要。 ADRD 的临床表现、病因和病理特征具有异质性 弹道。