The Noisy Life of the Musician: Implications for Healthy Brain Aging

音乐家的喧闹生活：对大脑健康老化的影响

• 批准号: 10346105
• 负责人: Erika E Skoe
• 金额: $ 32.54万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-05 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10346105
• 关键词: Accounting; Acoustics; Address; Adult; Age; Age Factors; Aging; Attention; Auditory; Auditory Evoked Potentials; Auditory Threshold; Benefits and Risks; Biometry; Brain; Childhood; Clinical; Cochlea; Communities; Confounding Factors (Epidemiology); Data; Ear; Elderly; Environment; Exposure to; Health Benefit; Health Hazards; Hearing; Human; Injury; Interview; Investigation; Knowledge; Lead; Life; Link; Literature; Loudness; Measures; Medial; Mediating; Methodology; Methods; Music; Neurosciences; Noise; Noise-Induced Hearing Loss; Outcome; Pilot Projects; Play; Prevention; Property; Publishing; Recommendation; Recurrence; Reflex action; Research; Resources; Risk; Risk Factors; Selection Bias; Socioeconomic Status; Speech Perception; Structure; System; Testing; Therapeutic; Training; Work; age related; aging brain; clinically significant; college; design; dosimetry; functional decline; hazard; healthy aging; hearing loss risk; improved; innovation; instrument; middle age; multidisciplinary; musician; neural circuit; noise exposure; normal hearing; novel; novel strategies; preservation; protective effect; relating to nervous system; sound; young adult

PROJECT SUMMARY Playing a musical instrument is a popular childhood and adult activity with documented health benefits. One of the most provocative, but least understood, proposed health benefits is preserved brain function in advanced age. Playing a musical instrument, however, can also pose significant health hazards, including those that come from routine exposure to noisy (loud) environments. Beyond the risks of hearing loss from loud environments, noise exposure is a significant risk factor for age-related functional declines. While both the benefits and risks of musical training have been widely studied, little attention has been given to their interplay. To understand the mechanisms that mediate the effects of musical training on the human brain, we must develop a more complete accounting of the risk factors that could counteract the benefits of musical training and the degree to which benefits persist in the face of these risks. To more fully harness the therapeutic benefits of music, we also need a better account of whether the benefits persist after a musician stops playing their instrument. These knowledge gaps motivate the proposed work on auditory brain aging, in which lifelong musicians will be compared to controls and to ex-musicians who have not played a musical instrument since childhood. The proposed work is grounded in our published studies of auditory brain aging, and our published and pilot studies on the interplay of musical training and noise exposure on the young adult auditory brain. The proposed work aims (1) to characterize current and lifetime noise exposure from music and non-music activities, (2) to investigate relations among lifelong musical training, lifetime noise exposure, and auditory-brain aging, and (3) to investigate relations between childhood musical training and later-life auditory-brain function. For all three aims, young adults (18- 24 years) will be compared to middle-aged adults (45-60 years). We hypothesize that music, as a form of acoustic enrichment and training, may mitigate the impact of noise injuries and age-related decline by strengthening the neural systems most vulnerable to being compromised. Our methodological approach is innovative, comprehensive, and corroborated by our prior work. We will use a novel combination of personal sound dosimetry and structured interviews to characterize the risk of noise injury. Noise exposure data will be combined with validated methods to study auditory brain aging across multiple neural circuits, using a statistical design that accounts for selection bias and confounding variables such as socioeconomic status and cochlear function. Most studies of human auditory aging focus on older adults (60+ years), with less attention on studying early-stage aging when opportunities for the prevention of functional decline are greater. This motivates our decision to focus on early-stage aging. The outcomes of this work may suggest new approaches to promote healthy brain aging and clinical recommendations about harnessing the therapeutic properties of music training to maximize benefits and minimize hazards. Our multidisciplinary study team has complementary expertise in auditory neuroscience (Skoe), noise exposure (Tufts), biostatistics (Harel), and aging (Kuchel).

项目摘要 演奏乐器是一种流行的童年和成人活动，具有记录在案的健康益处。之一 最具挑衅性但最不理解的是拟议的健康益处是在高级中保留的大脑功能 年龄。但是，演奏乐器也可能造成严重的健康危害，包括 从常规接触到嘈杂的环境。超越了来自大声环境的听力损失的风险， 噪声暴露是与年龄相关功能下降的重要危险因素。虽然好处和风险 音乐训练的研究已经广泛研究，对他们的相互作用几乎没有关注。理解 介导音乐训练对人脑的影响的机制，我们必须开发一个更完整的 计算可能抵消音乐训练的好处的风险因素和程度 面对这些风险，福利持续存在。为了更充分利用音乐的治疗益处，我们也需要 更好地说明音乐家在音乐家停止演奏乐器后是否持续存在。这些知识 差距激发了对听觉大脑衰老的拟议工作，其中将终身音乐家与对照组进行比较 以及从小就没有演奏乐器的前音乐家。拟议的工作是扎根的 在我们发表的关于听觉脑老化的研究以及我们关于音乐相互作用的发表和试点研究 年轻的成人听觉大脑的训练和噪音暴露。拟议的工作旨在（1）来表征 音乐和非音乐活动的当前和终生噪音暴露，（2）调查之间的关系 终身音乐训练，终生噪音曝光和听觉脑老化，以及（3）调查关系 在儿童音乐训练和后来的听觉脑功能之间。对于所有三个目标，年轻人（18-- 将24岁）与中年成年人（45 - 60年）进行比较。我们假设音乐是一种声学的形式 富集和训练，可以通过加强噪声伤害的影响和与年龄相关的下降来减轻 神经系统最容易受到损害。我们的方法论方法是创新的， 全面，并由我们的先前工作证实。我们将使用新颖的个人声音组合 剂量测定和结构化访谈以表征噪声损伤的风险。噪声暴露数据将组合 采用经过验证的方法来研究跨多个神经回路的听觉脑老化，使用统计设计 计算选择偏见和混淆变量（例如社会经济状况和人工耳蜗功能）。最多 人类听觉衰老的研究集中于老年人（60岁以上），对研究早期的关注较少 当预防功能下降的机会时，老化会更大。这激发了我们决定 专注于早衰。这项工作的结果可能暗示了促进健康大脑的新方法 有关利用音乐训练的治疗特性以最大化的老化和临床建议 益处并最大程度地减少危害。我们的多学科学习团队在听觉方面具有互补的专业知识 神经科学（SKOE），噪声暴露（簇），生物统计学（Harel）和衰老（Kuchel）。