Training Program in Molecular Medicine

分子医学培训计划

• 批准号: 8870380
• 负责人: Michael J. Caplan
• 金额: $ 18.25万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8870380
• 关键词: Molecular Medicine; Training Programs

DESCRIPTION (provided by applicant): In 2006 Yale started the innovative Medical Research Scholars Program (MRSP) with the mission of providing broad and deep Ph.D. training in the core basic science concepts of molecular biology, cell biology, biochemistry, genetics, physiology, pharmacology, and pathology, integrated with intensive exposure to medically oriented coursework and mentored clinical experiences designed specifically for Ph.D. students. The ultimate goal of this training is to prepare our students to be future interdisciplinary leader in the biomedical sciences, with a unique ability to pursue clinically relevant fundamental basic science inquiry aimed at elucidating the molecular mechanisms of disease. The MRSP has been supported by a combination of institutional funds and funds provided by the Howard Hughes Medical Institute (HHMI). The combination of substantial unmet demand from highly qualified students for admission (warranting expansion of the size of MRSP), the termination of HHMI support after the 2013-2014 academic year, and the desire to continue this highly successful ongoing program constitute the rationale for our Molecular Medicine (MM) Training Grant application. MRSP students participate in a variety of program activities designed to engage Ph.D. students in medically relevant training and experiences throughout their graduate studies. The classes focus first on normal human physiology, organ-based cell biology, and biostatistics, followed by human pathobiology and an introduction to drug discovery, validation, and clinical trials. MRSP students also have the option to participate with first-year Yale MD students in weekly small-group physiology "case conference" tutorials, in which they explore in depth the physiological underpinnings of particular disease states. The cornerstone of the MRSP is a two-year mentored clinical experience that provides students with in-depth exposure to the science behind human diseases and first-hand longitudinal encounters with patients to contextualize the mechanistic basis of disease in a way that is not possible through traditional classroom learning. In addition, MRSP students participate in a special research-in-progress series held jointly with the Yale Center for Clinical Investigation (YCCI)-an NIH-funded center that forms the nucleus for translational and mechanistic disease-focused research at Yale-and as the program grows we plan to incorporate an Annual Retreat (also in conjunction with the YCCI). In addition to these formal activities, the MRSP also provides ongoing mentoring to all MRSP trainees regarding selection of a thesis research laboratory and assembly of the dissertation committee to support the goal of the NIGMS Molecular Medicine program to provide training in the basic biomedical sciences with a focus on elucidating the mechanisms of human disease. Accordingly, we request funds for this MM Training Grant to support a total of five MRSP Ph.D. students per class year, with five second-year and five third-year students being supported at any given time (all first-year students are fully supported by institutional funds), with the expectation that MRSP students will complete the Ph.D. within six years.

描述（由申请人提供）： 2006 年，耶鲁大学启动了创新的医学研究学者计划 (MRSP)，其使命是提供广泛而深入的博士学位。分子生物学、细胞生物学、生物化学、遗传学、生理学、药理学和病理学等核心基础科学概念的培训，结合深入接触医学导向的课程和专为博士设计的指导临床经验。学生。本次培训的最终目标是让我们的学生成为未来生物医学领域的跨学科领导者，具有独特的能力进行临床相关的基础科学探究，旨在阐明疾病的分子机制。 MRSP 得到了机构资金和霍华德休斯医学研究所 (HHMI) 提供的资金的共同支持。高素质学生的入学需求大量未得到满足（需要扩大 MRSP 的规模）、2013-2014 学年之后 HHMI 支持的终止以及继续这一非常成功的持续项目的愿望，构成了我们分子医学（MM）培训补助金申请。 MRSP 学生参加各种旨在吸引博士生的项目活动。学生在整个研究生学习期间接受医学相关的培训和经验。这些课程首先关注正常人类生理学、基于器官的细胞生物学和生物统计学，然后是人类病理学和药物发现、验证和临床试验简介。 MRSP 学生还可以选择与耶鲁大学医学博士一年级学生一起参加每周的小组生理学“病例会议”教程，在其中深入探讨特定疾病状态的生理基础。 MRSP 的基石是为期两年的指导临床经验，让学生深入了解人类疾病背后的科学，并与患者进行第一手纵向接触，以一种通过其他方法无法实现的方式了解疾病的机制基础。传统的课堂学习。此外，MRSP 学生还参加了与耶鲁临床研究中心 (YCCI) 联合举办的正在进行中的特殊研究系列，该中心由 NIH 资助，构成耶鲁大学以转化和机制疾病为重点的研究核心。随着项目的发展，我们计划纳入年度静修活动（也与 YCCI 联合举办）。除了这些正式活动之外，MRSP 还为所有 MRSP 学员提供关于选择论文研究实验室和组建论文委员会的持续指导，以支持 NIGMS 分子医学计划的目标，即提供基础生物医学科学培训重点是阐明人类疾病的机制。因此，我们请求为该 MM 培训补助金提供资金，以支持总共五名 MRSP 博士。每班每年有 5 名二年级学生和 5 名三年级学生在任何特定时间得到支持（所有一年级学生都得到机构资金的全额支持），预计 MRSP 学生将完成博士学位。六年内。