Molecular Influences of Racial Disparities in Neuroendocrine Tumors

神经内分泌肿瘤中种族差异的分子影响

• 批准号: 10536896
• 负责人: UPENDER MANNE
• 金额: $ 18.56万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-23 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10536896
• 关键词: Address; Adherence; African American; African American population; Alabama; Applications Grants; Award; Basic Science; Behavioral; Behavioral Research; Bioethics; Bioinformatics; Bioinformatics Shared Resource; Biological; Biometry; Biotechnology; Cancer Biology; Cancer Burden; Cancer Center Planning Grant; Cancer Control; Cancer Etiology; Cancer Research Project; Clinical; Clinical Cancer Center; Clinical Research; Clinical Trials; Collaborations; Colorectal Cancer; Combined Modality Therapy; Communities; Complement; Comprehensive Cancer Center; Deep South; Development; Education; Education and Outreach; Educational Curriculum; Enrollment; Ensure; Ethics; Evaluation; Extramural Activities; Faculty; Foundations; Funding; Goals; Grant; Health Disparities Research; Healthcare Systems; Heart; Hospitals; Institution; Intervention; Latinx; Link; Malignant Neoplasms; Malignant neoplasm of prostate; Manuscripts; Master' s Degree; Medical; Medical Students; Methods; Minority-Serving Institution; Modeling; Molecular; Morehouse School of Medicine; NCI-Designated Cancer Center; Neuroendocrine Tumors; Outcome; Outreach Research; Patients; Peer Review; Physical activity; Pilot Projects; Policies; Population Sciences; Postdoctoral Fellow; Provider; Public Health Informatics; Publications; Publishing; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk Reduction; Scientist; Secure; System; Testing; Therapeutic Trials; Training; Training Programs; Underserved Population; Universities; Vision; anticancer research; base; biological research; cancer care; cancer education; cancer genomics; cancer health disparity; cancer risk; career; colorectal cancer screening; community involvement; dietary; education planning; education research; ethnic minority population; evidence base; faculty research; graduate student; health disparity; healthy lifestyle; high school; immunomodulatory strategy; improved; laboratory experience; lung cancer screening; member; minority investigator; minority student; multidisciplinary; next generation; outreach; outreach program; overexpression; personalized medicine; pre-clinical; pre-clinical research; programs; racial and ethnic; racial disparity; racial health disparity; recruit; research and development; rural dwellers; social; success; summer research; symposium; theories; traditional care; tumor-immune system interactions; twelfth grade; undergraduate student; underserved area; uptake

OVERALL: PROJECT SUMMARY: (Overall is identical to all three partnering institutions) This type-2 application is to strengthen and build upon the established U54 Partnership between Morehouse School of Medicine (MSM), Tuskegee University (TU), and the UAB O’Neal Comprehensive Cancer Center (UAB OCCC). The Partnership, located in the heart of the Southeast, a region with a large, historically underserved, African American (AA) population, has the overall goal of attaining excellence in research focused on elimination of cancer health disparities and on reducing the cancer burden among underserved populations in the region. The partnering institutions possess distinctive strengths that complement each other in achieving the proposed goal through integrated research, education, and outreach. The primary objectives are to enhance productive cancer research programs, to develop a pipeline of racial/ethnic minority investigators in cancer research at MSM and TU, and to increase the level of involvement of investigators conducting research on cancer disparities at the UAB OCCC. The Partnership has four Cores (Administrative, Outreach, Research Education, and Planning & Evaluation); two Full Research Projects; one Pilot Research Project; and two Shared Resources (Bioethics and Biostatistics/Bioinformatics). With these assets and activities, the Partnership will: 1) through the two full projects, a) determine if amplification and overexpression of TRIP13 contribute to prostate cancer aggressiveness and progression and b) develop combination therapy strategies that modulate the immune microenvironment for colorectal cancers and identify alternative targets adaptable to personalized medicine. The overall objectives of the Pilot Project are to characterize factors associated with uptake of lung cancer screening (LCS) in two different health care systems and to explore barriers and facilitators to LCS at the system, provider, and patient levels that will inform the development of a multi-level intervention. 2) through the Outreach Core, implement and evaluate an evidence-based, theory-informed, multi-level, clinical trial and cancer genomics education program that addresses the determinants for AA and Latinx participation in clinical trials and cancer genomics studies; 3) through the Research Education Core, employ an integrated research education program that involves capacity building and linkages to high school, undergraduate and graduate/medical students, postdoctoral fellows, medical residents, and early-stage investigators, allowing them to pursue careers in cancer research; and 4) provide funding for additional Pilot Research projects. The Planning & Evaluation Core will continually assess/evaluate outcomes of the cores, research projects, and shared resources. The Bioethics Shared Resource will promote and ensure adherence to bioethical principles and address ethical considerations in relationships between the institutions and between the institutions and communities. The Biostatistics and Bioinformatics Shared Resource will deliver statistical and bioinformatics support for all activities. Together, these actions will contribute to elimination of cancer health disparities.

总体：项目摘要：（总体上与所有三个合作局相同） 此类型2的应用是为了加强和建立在莫尔豪斯之间已建立的U54合作伙伴关系的基础上 医学院（MSM），Tuskegee University（TU）和UB O'Neal综合癌症（UAB） OCCC）。 非洲裔美国人（AA）人口的总体目标是使卓越的研究集中在淘汰赛上 癌症健康差异和减轻军团未遇到的人口的癌症负担。 合作伙伴具有具有独特的优势，可以在实现拟议的方面相互补充 通过综合研究，教育和外展的目标。 癌症研究计划，以开发癌症研究中种族/族裔少数族裔研究人员的管道 MSM和TU，并增加进行癌症差异研究的研究人员参与的水平 在UBCCC，合作伙伴关系有四个核心（行政，外展，研究教育， 计划和评估）； （生物伦理学和生物阶层/生物信息学）。 两个完整的项目，a）确定TRIP13的扩增和过表达是否有助于前列腺癌 侵略性和进步和b）制定组合线程策略免疫 大肠癌的微环境，并确定适合个性化药物的替代靶标 试点项目的总体目标是表征与肺癌筛查摄取有关的因素 （LCS）在两个不同的医疗保健系统中 以及将通过外展核心的多层次干预措施开发的患者水平， 实施和评估基于证据的，理论的，多层次，临床试验和癌症基因组学 教育计划AA和Latinx Partinx Partinx参与临床试验和cancancer的决定因素 基因组学研究； 3）通过研究教育核心 这涉及Capace建设以及与高中的联系，地下和研究生/医学生， 博士后研究员，医疗居民和早期调查员，使他们允许他们从事癌症的扭力职业 研究； 4）为其他飞行员研究项目提供资金。 不断评估/评估核心，研究项目和共享资源 共享的资源将促进并确保遵守生物伦理原则并解决道德意见 在研究所之间，研究所与社区之间的关系 生物信息学共享资源将为所有活动提供统计和生物信息学支持。 这些行动将导致消除癌症健康差异。