Commercialization of integrated electrode-electronics system for large scale, long-lasting electrophysiology

用于大规模、持久电生理学的集成电极电子系统的商业化

• 批准号: 10651898
• 负责人: Loren M Frank
• 金额: $ 65.28万
• 依托单位: SPIKEGADGETS, LLC
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10651898
• 关键词: Animals; BRAIN initiative; Behavior; Behavioral; Brain; Brain Injuries; Brain region; Chronic; Cicatrix; Code; Complex; Computers; Contracts; Coupling; Data; Data Collection; Devices; Electrodes; Electronics; Electrophysiology (science); Goals; Head; Implant; Individual; Laboratories; Macaca; Measurement; Measures; Mechanics; Miniaturization; Movement; Neurons; Neurosciences Research; Operative Surgical Procedures; Pattern; Phase; Procedures; Process; Protocols documentation; Rattus; Readiness; Research Personnel; Resistance; Resolution; Rodent; Route; Sampling; Shipping; Silicon; Site; Small Business Innovation Research Grant; Sterilization; Stream; Structure; System; Techniques; Technology; Thick; Thinness; Tissues; Tungsten; Weight; Work; analog; behavior measurement; commercialization; data integration; density; design; digital; experimental study; fabrication; flexibility; implantation; instrument; lithography; manufacture; meter; millimeter; miniaturized device; neural; neurotechnology; next generation; nonhuman primate; parity; power consumption; prototype; scale up; tool; usability; user-friendly

PROJECT SUMMARY Examining how behavior arises from the complex interconnected activity of the brain is a cornerstone of neuroscience research. A recent technological advance in neurotechnology is enabling studies where the parallel activity of thousands of neurons can be studied in rodent brains. The Neuropixels probe, allowing 384 channels of electrophysiological data to be observed from the brain, is now a valuable tool for next-generation experiments. One goal of this project is to provide a commercial alternative to the Neuropixels probe and associated electronics that will enable feature parity in recording capability, but also be usable in scientific applications currently unaddressed by the existing Neuropixels probe. Our proposed solution is partially enabled by the makers of the Neuropixles probes—IMEC has recently made commercially available the electronics of the probes as a standalone 384 channel chip without the silicon electrodes attached. By connecting this proven technology to a new type of electrode array—flexible polyimide-based probes—we outline a strategy to offer technology with similar channel density that is 1) is resistant to breakage upon insertion, 2) enables closely-spaced implantation sites, and 3) has a significant reduction in glial scarring compared to silicon probes, enabling extremely stable recordings for months. Furthermore, by coupling this probe to powerful datalogging electronics, we will offer a way to scale channel counts to above 3000 without the need for cables between the animal and a computer.

项目摘要 检查行为是如何源于大脑的复杂互连活性是一个 神经科学研究的基石。神经技术的最新技术进步是 在啮齿动物中可以研究数千个神经元的平行活性的研究 大脑。神经质子探针，可以观察到384个电生理数据通道 从大脑中，现在是下一代实验的宝贵工具。这个项目的一个目标是 提供神经质子探针和相关电子的商业替代品 在录制功能中启用功能奇偶校验，但在目前的科学应用中也可用 现有的神经质子探针未加上。我们提出的解决方案部分由 神经蛋白问题的制造商 - IMEC最近在商业上可用 探针的电子作为独立的384通道芯片，没有硅电子 随附的。通过将这种验证的技术连接到一种新型的电极阵列 - 基于聚酰亚胺的问题 - 我们概述了提供具有相似频道密度的技术的策略 那就是1）在插入时具有抗性，2）启用紧密间隔的植入位点， 3）与硅问题相比，神经胶质疤痕的降低显着降低，使得极大 稳定的录音数月。此外，通过将此探测器与强大的数据归结 电子产品，我们将提供一种将频道计数扩展到3000以上的方法，而无需电缆 在动物和计算机之间。