Administrative Core

行政核心

• 批准号: 10649657
• 负责人: ROBERT H MACH
• 金额: $ 40.84万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-24 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10649657
• 关键词: Achievement; Agreement; Clinical; Communication; Development; Doctor of Philosophy; Documentation; Ensure; Evaluation; Goals; Image; Individual; Infrastructure; Institutional Review Boards; Intellectual Property; Investigational Drugs; Joints; Maintenance; Mission; Monitor; Pharmaceutical Chemistry; Philadelphia; Positron-Emission Tomography; Protein Biochemistry; Protocols documentation; Radiation; Radiochemistry; Research; Research Personnel; Research Project Grants; Resources; Schedule; Site; Structure; Structure-Activity Relationship; Teleconferences; Translations; Update; Writing; first-in-human; high throughput screening; material transfer agreement; meetings; member; molecular imaging; operation; programs; radiotracer; screening; structural biology; symposium

ADMINISTRATIVE CORE The Administrative Core of this U19 Center will be responsible for coordinating all activities associated with the CW2IP2. This will include the scheduling of the biweekly calls of the Center Executive Steering Committee and the monthly joint call with the members of the Clinical Core. The Administrative Core will also organize the bi-annual conference call and annual meeting of the External Liaison Committee. The Administrative Core will provide the oversight needed to direct the efficient operation of the CW2IP on a day-to-day basis, such as the shipment of research materials between the different labs involved in the consortium. The Administrative Core will also provide financial oversight of the U19 Center. The core will be directed by Robert H. Mach, Ph.D. the Director of this U19 Center application. Given the multi-site structure of the Medicinal Chemistry and Radiochemistry (MCRC) Core, a key component of the Administrative Core is the Center Executive Steering Committee, which consists of the site P.I.s of the MCRC core. The Executive Steering Committee will meet via video teleconference on a biweekly basis to provide updates on the compound screening and medicinal chemistry studies. The Executive Steering Committee will be responsible for identifying which compounds identified as hits will be chosen for full evaluation in structure-activity relationship studies. Another function of the biweekly conference calls is to review upcoming milestones, and to determine if the U19 Center project is on track for achieving the milestones. The Administrative Core will also be responsible for the obtaining regulatory approval for the PET radiotracers chosen for translation for first-in-human studies.

行政核心 该U19中心的管理核心将负责协调所有相关活动 与CW2IP2。这将包括安排中心高管转向的每两周通话 委员会和每月与临床核心成员的联合电话。行政核心将 还组织外部联络委员会的两年一次电话会议和年度会议。这 行政核心将提供指导CW2IP有效操作所需的监督 日常的基础，例如在涉及的不同实验室之间运输研究材料 财团。行政核心还将提供对U19中心的财务监督。核心 将由罗伯特·H·马赫（Robert H. Mach）博士执导。该U19中心申请的主管。 鉴于药物化学和放射化学（MCRC）核心的多站点结构， 行政核心的组成部分是中心执行指导​​委员会，该委员会由 MCRC核心的站点P.I.S。执行指导委员会将通过视频电话会议开会 双周的基础，以提供有关化合物筛查和药物化学研究的最新信息。这 执行指导委员会将负责确定哪些被确定为命中的化合物将 选择在结构活性关系研究中进行全面评估。每两周的另一个功能 电话会议是审查即将到来的里程碑，并确定U19中心项目是否在正轨 为了实现里程碑。行政核心还将负责获得监管 批准选择用于首次人类研究的翻译的宠物放射性示例。