Administrative Core

行政核心

• 批准号: 10649657
• 负责人: ROBERT H MACH
• 金额: $ 40.84万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-24 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10649657
• 关键词: Achievement; Agreement; Clinical; Communication; Development; Doctor of Philosophy; Documentation; Ensure; Evaluation; Goals; Image; Individual; Infrastructure; Institutional Review Boards; Intellectual Property; Investigational Drugs; Joints; Maintenance; Mission; Monitor; Pharmaceutical Chemistry; Philadelphia; Positron-Emission Tomography; Protein Biochemistry; Protocols documentation; Radiation; Radiochemistry; Research; Research Personnel; Research Project Grants; Resources; Schedule; Site; Structure; Structure-Activity Relationship; Teleconferences; Translations; Update; Writing; first-in-human; high throughput screening; material transfer agreement; meetings; member; molecular imaging; operation; programs; radiotracer; screening; structural biology; symposium

ADMINISTRATIVE CORE The Administrative Core of this U19 Center will be responsible for coordinating all activities associated with the CW2IP2. This will include the scheduling of the biweekly calls of the Center Executive Steering Committee and the monthly joint call with the members of the Clinical Core. The Administrative Core will also organize the bi-annual conference call and annual meeting of the External Liaison Committee. The Administrative Core will provide the oversight needed to direct the efficient operation of the CW2IP on a day-to-day basis, such as the shipment of research materials between the different labs involved in the consortium. The Administrative Core will also provide financial oversight of the U19 Center. The core will be directed by Robert H. Mach, Ph.D. the Director of this U19 Center application. Given the multi-site structure of the Medicinal Chemistry and Radiochemistry (MCRC) Core, a key component of the Administrative Core is the Center Executive Steering Committee, which consists of the site P.I.s of the MCRC core. The Executive Steering Committee will meet via video teleconference on a biweekly basis to provide updates on the compound screening and medicinal chemistry studies. The Executive Steering Committee will be responsible for identifying which compounds identified as hits will be chosen for full evaluation in structure-activity relationship studies. Another function of the biweekly conference calls is to review upcoming milestones, and to determine if the U19 Center project is on track for achieving the milestones. The Administrative Core will also be responsible for the obtaining regulatory approval for the PET radiotracers chosen for translation for first-in-human studies.

行政核心 该 U19 中心的行政核心将负责协调所有相关活动 与CW2IP2。这将包括安排中心行政指导每两周一次的电话会议 委员会以及每月与临床核心成员的联合电话会议。行政核心将 还组织每两年一次的电话会议和对外联络委员会年会。这 管理核心将提供指导 CW2IP 高效运行所需的监督 日常工作，例如在参与研究的不同实验室之间运输研究材料 财团。行政核心还将对 U19 中心进行财务监督。核心 由 Robert H. Mach 博士执导该 U19 中心申请的主任。 鉴于药物化学和放射化学 (MCRC) 核心的多位点结构，一个关键 行政核心的组成部分是中心执行指导​​委员会，由 MCRC 核心的站点 P.I.。执行指导委员会将通过视频电话会议召开 每两周提供化合物筛选和药物化学研究的最新信息。这 执行指导委员会将负责确定哪些被确定为命中的化合物将 被选择用于结构-活性关系研究的全面评估。双周刊的另一个功能 电话会议的目的是审查即将到来的里程碑，并确定 U19 中心项目是否步入正轨 实现里程碑。行政核心还将负责获得监管 批准用于首次人体研究的 PET 放射性示踪剂。