Long-term Effects of a Natural Disaster on Cognitive Aging, Dementia, Health and Well-being of Older Adults

自然灾害对老年人认知老化、痴呆、健康和福祉的长期影响

• 批准号: 10649683
• 负责人: ELIZABETH A FRANKENBERG
• 金额: $ 46.05万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10649683
• 关键词: Address; Affect; Age; Aging; Alzheimer disease screening; Alzheimer' s Disease; Alzheimer' s disease related dementia; Animal Model; Anthropometry; Area; Attention; Back; Biological; Blood Pressure; Clinical; Cognition; Cognitive; Cognitive aging; Communities; Complement; Data; Dementia; Disasters; Disease; Earthquakes; Economics; Elderly; Emotional; Event; Exposure to; Family; Friends; Health; Home; Household; Human; Impaired cognition; Indian Ocean; Individual; Indonesia; Inflammation; Knowledge; Light; Link; Literature; Long-Term Effects; Measurement; Measures; Mediating; Natural Disasters; Natural experiment; Nature; Neurosciences; Observational Study; Outcome; Pathway interactions; Personal Satisfaction; Persons; Physiological; Play; Population; Poverty; Premature Mortality; Prevalence; Process; Public Domains; Random Allocation; Recovery; Research; Research Design; Resource-limited setting; Resources; Respondent; Risk; Role; Science; Shock; Site; Source; Stress; Sumatra; Surveys; Survivors; Tablets; Time; Tsunami; Water; acetone hydrazone; blood-based biomarker; cardiometabolic risk; cardiometabolism; cognitive performance; cognitive testing; data resource; executive function; experience; follow-up; innovation; psychosocial; reconstruction; resilience; response; stressor

Abstract This project will provide rigorous scientific evidence on the effects, over the long-term, of exposure to stressors on cognitive performance, physical and psychosocial health and well- being of older adults in Indonesia using extremely rich population-representative longitudinal data collected from about 12,000 older respondents (>40y) before and for 20 years after the 2004 Indian Ocean earthquake and tsunami, the Study of the Tsunami Aftermath and Recovery (STAR). The tsunami was a large and unanticipated natural disaster that devastated some coastal communities while other comparable, nearby communities were untouched because of the wave direction, land and seabed topography. Exposure to the tsunami is, therefore, plausibly exogenous in our study area, coastal Aceh and North Sumatra, so that estimated effects of exposure to the stress of the tsunami can be given a causal interpretation. We will investigate how these effects vary with the nature of individual-specific experiences of the tsunami including being caught up in the water, losing family and loss of economic livelihoods. The research will document the extent of resilience and recovery among older adults in the face of the tsunami and its aftermath, as well as the role played in these processes by individual, household, family and community resources, including post-tsunami reconstruction. Special attention is paid to the measurement and interpretation of cognition and health. All older respondents will complete assessments used to screen for Alzheimer's disease which will be clinically validated. For a randomly selected sub-sample of older respondents, the screeners will be complemented with innovative neuroscience-based measures of executive functioning and emotional control assessed on tablets in the home. Validated cardio-metabolic biological risks will be collected for the same subsample of older adults to provide uniquely rich, high quality measures of key outcomes designed for this research. The links between cognition and health will be described using contemporaneous measures and exploiting longitudinal data on health that reach back 15 years.

抽象的 该项目将对长期的影响提供严格的科学证据 暴露于认知表现，身体和社会心理健康以及良好的压力源 使用极富人口代表性的纵向，在印度尼西亚成为老年人 在大约12,000名老年受访者（> 40年）之前和20年后收集的数据 2004年印度洋地震和海啸，《海啸的研究》 （星星）。海啸是一场大型而意外的自然灾害，摧毁了一些 沿海社区尽管其他可比的社区，附近的社区没有触及 波动方向，陆地和海底地形。因此，暴露于海啸是 在我们的研究区，沿海亚齐和北部苏门答腊的研究区域外源，因此估计 暴露于海啸应力的影响可以给予因果解释。我们将 研究这些影响如何随着个人特定经验的性质而变化 海啸，包括被赶上水，失去家庭和失去经济生计。 该研究将记录面对老年人的韧性和恢复程度 海啸及其后果以及个人在这些过程中所扮演的角色， 家庭，家庭和社区资源，包括海啸后的重建。 特别注意认知和健康的测量和解释。所有年龄较大 受访者将完成用于筛查阿尔茨海默氏病的评估，这将是 经过临床验证。对于随机选择的老年受访者的子样本，筛选人员将 与创新的基于神经科学的执行功能和 在家里的平板电脑上评估情绪控制。经过验证的心脏代谢生物学风险 将针对老年人的同一子样本收集，以提供独特的高质量 为这项研究设计的关键结果的度量。认知与健康之间的联系 将使用同时的措施来描述并利用有关健康的纵向数据 那回到了15年。