Mentoring Translational Researchers for Careers in Pediatric Global Health

指导转化研究人员在儿科全球健康领域的职业生涯

• 批准号: 10646481
• 负责人: MARGARET E FEENEY
• 金额: $ 19.16万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-03 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646481
• 关键词: Academia; Address; Antigens; Antimalarials; Archives; Award; Bioinformatics; Biological; Blood; CD4 Positive T Lymphocytes; Cells; Cessation of life; Characteristics; Chemoprevention; Chemopreventive Agent; Child; Childhood; Chronic; Clinical; Clinical Research; Communicable Diseases; Computational Biology; Containment; Country; Creativeness; Cytomegalovirus; Cytomegalovirus Infections; Cytometry; Data; Data Analyses; Development; Effectiveness; Epidemiologist; Exposure to; Faculty; Fellowship; Fostering; Funding; Generations; Genetic Transcription; Goals; Grant; Heterogeneity; Human; Immune; Immune response; Immunity; Immunologics; Immunology; In Vitro; Infant; Infection; Infrastructure; Institution; Interruption; K-Series Research Career Programs; Leadership; Life; Malaria; Malaria Vaccines; Mediating; Medicine; Memory; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Molecular; Mononuclear; Mothers; Outcome; Parasitemia; Pathway interactions; Pediatric cohort; Pediatrics; Perinatal; Peripheral Blood Mononuclear Cell; Phenotype; Pilot Projects; Plasma; Positioning Attribute; Postdoctoral Fellow; Process; Program Description; Proliferating; Regulatory T-Lymphocyte; Research; Research Infrastructure; Research Personnel; Residencies; Resources; Sampling; Site; T cell response; T-Cell Development; T-Lymphocyte; Testing; Training Programs; Translating; Uganda; Umbilical Cord Blood; Underrepresented Minority; United States National Institutes of Health; Vaccines; Viral; Viremia; Woman; acquired immunity; career; career development; cohort; congenital infection; cytokine; doctoral student; early childhood; experimental study; exposed human population; fetal; field study; forging; genomic data; global health; human subject; immunoregulation; in utero; interest; large datasets; malaria transmission; medical schools; member; multidisciplinary; pathogen; patient oriented; patient oriented research; postnatal; pre-doctoral; prenatal exposure; preventive intervention; professor; programs; prospective; randomized, clinical trials; response; single-cell RNA sequencing; skill acquisition; skills; student mentoring; training opportunity; translational immunology; translational scientist; transmission process; vaccine development

Project Summary/Abstract Interest in global health among applicants to medical schools, residency programs, and infectious disease fellowships has grown enormously in recent years, but the career development pathways for translating this interest into successful academic careers remain poorly defined and perilous, with relatively few mentors available in academia. The candidate for this K24 Award renewal is a Professor of Pediatrics and Medicine who has established a successful research and mentoring program to investigate the immune response to childhood malaria and identify in vitro correlates of protective immunity among children in highly malaria endemic settings. This research program is based upon strong collaborative relationships with leading malaria epidemiologists and clinical trialists working in Uganda. The PI and her collaborators have forged an effective multidisciplinary team and have built substantial research infrastructure to conduct field studies in Tororo, Uganda, a setting of exceptionally high malaria transmission intensity. Malaria is the leading cause of pediatric deaths in Uganda and claims the life of one million children worldwide each year. The need for an effective vaccine against malaria is self-evident. However, the iterative process of vaccine development, refinement, and testing would be greatly aided by a better understanding of the immunologic effector mechanisms that confer protection from malaria, as well as immune subversion mechanisms that may hinder the development of durable immunity. The candidate has established a systematic approach to mentoring both pre-doctoral students and early career clinician-investigators engaged in patient-oriented research. Several trainees have obtained NIH K Award support, and some have recently assumed independent faculty positions at leading research institutions. Mentoring will be provided in the context of the candidate's own funded research program, which provides numerous opportunities for add-on projects initiated by trainees. The proposed studies will use samples and data from well-characterized pediatric cohorts in Uganda to identify correlates of protective immunity to malaria, and to determine how the natural acquisition of antimalarial immunity is altered by chemopreventive interventions and by prenatal exposure to malaria. In addition, this award will address fundamental questions regarding how fetal T cells respond to pathogen-derived antigens encountered in utero. The primary goal of this K24 will be to mentor young investigators with the skills required to conduct high quality translational immunology research, encourage their passion for patient-oriented global health research, and help them to become successful independent investigators. Specific mentoring emphases during the K24 renewal period will be on helping trainees to acquire the skills in bioinformatics and genomic data analysis that are needed for emerging high-parameter single cell immune profiling approaches (mass cytometry, single cell RNA sequencing), and to foster the careers of women, under-represented minorities, and investigators from low-resource countries to become successful academic faculty members.

项目摘要/摘要 申请人对医学院，居住计划和传染病的兴趣 近年来，奖学金已大大增长，但是翻译这一事业发展途径 对成功的学术职业的兴趣仍然很差和危险，导师相对较少 可在学术界购买。该K24奖的候选人是儿科和医学教授 谁建立了一项成功的研究和指导计划，以调查对 儿童疟疾并确定高度疟疾儿童保护性免疫的体外相关性 地方性环境。该研究计划基于与领先疟疾的牢固合作关系 在乌干达工作的流行病学家和临床试验者。 PI和她的合作者已经有效 多学科团队，并建立了大量的研究基础设施，以在Tororo进行现场研究 乌干达，一种异常高的疟疾传播强度的环境。疟疾是小儿的主要原因 乌干达的死亡人数每年在全球享有一百万儿童的寿命。需要有效的 针对疟疾的疫苗是不言而喻的。但是，疫苗开发，改进的迭代过程， 通过更好地理解免疫学效应器机制，测试将得到极大的帮助 赋予疟疾的保护，以及可能阻碍发展的免疫颠覆机制 耐用的免疫力。候选人已经建立了一种系统的指导两种预期的方法 学生和早期职业临床医生评估者从事以患者为导向的研究。几个学员有 获得了NIH K奖的支持，有些人最近在领导领导领导领导方面担任独立教师职务 研究机构。将在候选人自己的资助研究计划的背景下提供指导 这为受训人员发起的附加项目提供了许多机会。拟议的研究将使用 来自乌干达特征良好的小儿同伙的样品和数据，以识别保护性的相关性 对疟疾的免疫力，并确定抗疟疾免疫的自然习得如何通过 化学预防干预措施和产前暴露于疟疾。此外，该奖项将解决 关于胎儿T细胞如何应对子宫内遇到的病原体衍生抗原的基本问题。 该K24的主要目标是指导年轻的调查员，以高度进行技能 质量转化免疫学研究，鼓励他们对以患者为导向的全球健康研究的热情， 并帮助他们成为成功的独立调查员。 K24期间的特定指导重点 续签期将帮助学员获得生物信息学和基因组数据分析的技能 新兴高参数单细胞免疫分析方法需要（质量细胞仪，单细胞） RNA测序），并促进妇女的职业，代表性不足的少数群体和研究人员 低资源国家成为成功的学术教师。