Research Core

研究核心

• 批准号: 10646279
• 负责人: HEATHER M STAPLETON
• 金额: $ 62.6万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-10 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10646279
• 关键词: Air; Biology; Chemicals; Collaborations; Communities; Complex Mixtures; Consultations; Core Facility; Data; Databases; Development; Doctor of Philosophy; Dust; Elements; Ensure; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollutants; Epidemiologist; Experimental Designs; Exposure to; Flame Retardants; Health; Human; Infrastructure; Laboratories; Mass Spectrum Analysis; Measurement; Measures; Metals; Methodology; Methods; Organic Chemicals; Pesticides; Plasticizers; Poly-fluoroalkyl substances; Positioning Attribute; Preparation; Protocols documentation; Qualifying; Quality Control; Research; Research Personnel; Resolution; Resources; Sampling; Scientist; Services; Silicones; Soil; Structure; Superfund; Technical Expertise; Technology; Trace Elements; Trace metal; United States National Institutes of Health; Universities; Vision; Water; Work; data centers; data harmonization; experience; exposed human population; improved; instrumentation; member; novel; organic contaminant; phthalates; programs; quality assurance; sample collection; screening

PROJECT ABSTRACT The purpose of the Duke Environmental Analysis Laboratory (DEAL) Hub is to offer a comprehensive suite of analytical services to support epidemiologists and health researchers conducting studies focusing on the impact of environmental contaminant exposures on human health. The Environmental Sample Analysis Resource (ESAR) Core of the DEAL Hub will help achieve this vision by providing analytical services for the analysis of organic chemicals and inorganic elements from diverse sample media. ESAR will utilize cutting- edge technology and approaches for suspect-screening and non-targeted analyses of chemicals using high- resolution mass spectrometry and will separate sampling into three distinct laboratories: Targeted Organic, Targeted Inorganic, and Untargeted Organic. All three of the laboratories will provide consultation and advice to HHEAR Network researchers on experimental design, exposure assessment, sample collection, and processing, efforts coordinated by the project management expertise of the DEAL Administrative Core. The Targeted Organic Contaminant Analysis Lab (directed by Dr. Heather Stapleton) will provide services for sample preparation, extraction and quantitative analysis of organic contaminants (e.g., flame retardants, polyflouroalkyl substances, phthalates, plasticizers, etc.) in diverse environmental media. The Targeted Inorganic Analysis Lab (directed by Dr. Heileen Hsu-Kim) will provide the same services for trace elements (e.g., metal) with a focus on speciation and bioaccessibility. Finally, the Non-Targeted High Resolution Mass Spectrometry Lab will provide high-resolution, accurate-mass mass spectrometry services for use in developing exposomics approaches and methodologies in order to help measure the totality of human exposure to chemicals (this effort will be directed by Dr. Lee Ferguson). The unique structure of the ESAR will allow the Co-Directors to utilize their relevant expertise in their own labs, while also collaborating and sharing information in order to achieve the overarching aims of the ESAR. In addition, the ESAR Co-directors will work collaboratively and bi-directionally with the Developmental Core to improve the efficiency of extraction methods, build consistency in the targeted and non-targeted method workflows, and expand the analyte list of the Targeted Organic Contaminant Analysis Lab as new emerging contaminants are identified.

项目摘要 杜克环境分析实验室（交易）中心的目的是提供一套全面的套件 分析服务以支持流行病学家和健康研究人员进行研究，以 环境污染物暴露对人类健康的影响。环境样本分析 交易中心的资源（ESAR）核心将通过为该愿景提供分析服务来帮助实现这一愿景 分析来自不同样本介质的有机化学物质和无机元素。 Esar将利用剪裁 - 边缘技术和方法，用于使用高级的化学物质进行可疑和非目标分析 分辨率质谱法，并将采样分为三个不同的实验室：靶向有机物， 靶向无机和无靶的有机物。这三个实验室将提供咨询和 向HHEAR网络研究人员提供有关实验设计，暴露评估，样本收集和 处理，由交易行政核心项目管理专业知识协调的努力。这 有针对性的有机污染物分析实验室（由Heather Stapleton博士指导）将为 对有机污染物的样品制备，提取和定量分析（例如，阻燃剂， 多种环境培养基中的多氟烷基物质，邻苯二甲酸酯，增塑剂等）。目标 无机分析实验室（由Heileen Hsu-kim博士指导）将为微量元素提供相同的服务 （例如，金属）着重于形成性和生物搜索性。最后，非目标的高分辨率质量 光谱实验室将提供高分辨率，准确的质量质谱服务，用于 开发说明组学方法和方法论，以帮助衡量人类的整体 暴露于化学物质（这项工作将由李·弗格森（Lee Ferguson）博士指导）。 ESAR的独特结构将 允许联合导演在自己的实验室中利用其相关专业知识，同时还合作和共享 为了实现ESAR的总体目的，信息。此外，ESAR联合导演将工作 与发育核心进行协作和双向，以提高提取效率 方法，在目标和非目标方法工作流程中建立一致性，并扩展 鉴定出靶向有机污染物分析实验室作为新的新兴污染物。