Cancer Epigenetics Training (CET) Program

癌症表观遗传学培训 (CET) 计划

• 批准号: 10646461
• 负责人: PETER A JONES
• 金额: $ 47.04万
• 依托单位: VAN ANDEL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-05 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646461
• 关键词: Epigenetic Process; Malignant Neoplasms; Training Programs

PROJECT SUMMARY This proposal seeks to develop a dedicated Cancer Epigenetics Training (CET) program at Van Andel Research Institute (VARI) to train two new postdoctoral fellows per year for three years each. The objective of the CET is to prepare 10 postdoctoral fellows to become independent academic and industry research leaders in the field of cancer epigenetics. The CET program will build upon the Center for Epigenetics that was established in 2014 by Peter Jones, Ph.D., D.Sc. (hon) and has grown into a world-class, internationally recognized center of excellence for basic and translational epigenetics research. To launch the CET program, we have assembled a team of 9 mentors and 6 co-mentors who collectively hold ~$5.7M of funding per year and have highly complementary and interdisciplinary cancer and epigenetics expertise. CET faculty include several epigenetics pioneers; two members of the National Academy of Sciences; the Van Andel Institute Stand Up to Cancer Epigenetics Dream Team (VAI-SU2C); two leaders of The Cancer Genome Atlas (TCGA) project; and mentors/co-mentors from all career stages. Trainees will be able to pursue basic and translational research projects in cancer biology; tumorigenesis, cellular development and differentiation; mechanisms governing DNA methylation and chromatin regulation; epigenomics and advanced tool development; GWAS and EWAS; transgenerational inheritance; structural biology; metabolism; and epigenetic therapies. The CET program is overseen by a dedicated Advisory Committee composed of domain-level experts from academic, industrial, and clinical careers. We have developed a targeted diversity and recruitment plan to increase the T32-eligible pool size and attract and retain individuals from underrepresented groups. Upon acceptance, each Trainee is assigned an Individual Development Team (IDT) to coach, mentor, and guide the Trainee through the scientific and non-scientific dimensions of career development. The faculty and CET Trainees are supported by a dedicated Office of Postdoctoral Affairs that is directed by a PhD-level biomedical career development professional. Each Trainee is required to complete a comprehensive curriculum of scientific and professional development training. Key deliverables and milestones for T32 Trainees include annual seminars (internal and external); at least one semester of teaching or mentoring experience; one first-authored publication; and at least one submitted F32 (or equivalent) and K99/R00 application. The training requirements and expectations are formalized within Individual Development Plans (IDPs) that are reviewed annually by the Advisory Committee. Research-related, individualized training not otherwise defined in the CET training program is provided by VARI. The CET will be rigorously evaluated through entrance, annual, exit, and alumni assessments. With the superlative faculty, resources, and guidance afforded by the CET, postdoctoral fellows will emerge with a comprehensive, multi-disciplinary skill set, perspective, and foundation from which to establish their independent research careers in cancer epigenetics.

项目概要 该提案旨在在 Van Andel 制定专门的癌症表观遗传学培训 (CET) 计划 研究所（VARI）每年培训两名新博士后，每人为期三年。目标 CET的目标是培养10名博士后成为独立的学术和行业研究人员 癌症表观遗传学领域的领导者。 CET 项目将建立在表观遗传学中心的基础上 成立于 2014 年，由 Peter Jones 博士、理学学士创立。 （荣誉）并已成长为世界一流的国际 公认的基础和转化表观遗传学研究卓越中心。为了启动 CET 计划， 我们组建了一支由 9 名导师和 6 名联合导师组成的团队，每年总共持有约 570 万美元的资金 并拥有高度互补和跨学科的癌症和表观遗传学专业知识。 CET教师包括 几位表观遗传学先驱；两名美国国家科学院院士；范安德尔研究所 对抗癌症表观遗传学梦之队 (VAI-SU2C)；癌症基因组图谱 (TCGA) 的两位领导者 项目;以及来自各个职业阶段的导师/共同导师。学员将能够学习基础知识和翻译知识 癌症生物学研究项目；肿瘤发生、细胞发育和分化；机制 控制 DNA 甲基化和染色质调控；表观基因组学和先进工具开发；全基因组关联分析 和EWAS；跨代遗传；结构生物学；代谢;和表观遗传疗法。六级考试 该计划由专门的咨询委员会监督，该委员会由来自学术界、 工业和临床职业。我们制定了有针对性的多元化和招聘计划，以增加 符合 T32 资格的池规模，并吸引和留住代表性不足群体中的个人。验收后， 每个受训者都被分配一个个人发展团队 (IDT) 来辅导、辅导和指导受训者 通过职业发展的科学和非科学维度。教师和 CET 学员是 由专门的博士后事务办公室支持，该办公室由博士级生物医学职业指导 开发专业。每位学员都必须完成科学和技术方面的综合课程 专业发展培训。 T32 学员的主要成果和里程碑包括年度研讨会 （内部和外部）；至少一个学期的教学或指导经验；第一作者之一 发布;以及至少一份已提交的 F32（或同等学历）和 K99/R00 申请。培训内容 要求和期望在经过审查的个人发展计划 (IDP) 中正式确定 每年由咨询委员会审议。与研究相关的个性化培训，未在本指南中另有定义 CET培训计划由VARI提供。 CET将通过入学、年度、 退出和校友评估。凭借 CET 提供的一流师资、资源和指导， 博士后研究员将拥有全面的、多学科的技能、视角和基础 从中建立他们在癌症表观遗传学方面的独立研究生涯。