Intervening Early with Neglected Children: Key Behavioral and Neurobiological Outcomes in Adolescence

对被忽视的儿童进行早期干预：青春期的关键行为和神经生物学结果

基本信息

批准号：
10643830
负责人：
Mary Dozier
金额：
$ 64.38万
依托单位：
UNIVERSITY OF DELAWARE
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-02-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10643830
关键词：
15 year old Adolescence Adolescent Age Amygdaloid structure Anxiety Autonomic nervous system Behavior Behavior assessment Behavioral Brain Child Child Rearing Clinical Trials Design Control Groups Coupled Development Domestic Violence Early Intervention Emotional Emotions Face Family Frequencies Friends Funding Homelessness Hydrocortisone Image Infant Inferior Informal Social Control Intervention Learning Measures Medial Mediating Mediation Mental Health Mental disorders Modification Nervous System Physiology Neurobiology Outcome Parents Pattern Physiological Physiology Prefrontal Cortex Prevention Production Randomized Recording of previous events Regulation Reporting Risk Salivary Secure Structure Time Visual System adolescent brain development behavioral outcome biobehavior brain circuitry child depression child neglect child protective service design early childhood early life adversity efficacy evaluation emotion regulation expectation experience group intervention infancy intervention effect middle childhood neglect neural neural circuit neurodevelopment primary caregiver randomized, clinical trials response

项目摘要

PROJECT SUMMARY/ ABSTRACT Parents serve as co-regulators for their young children, helping them regulate behaviors, emotions, and physiology and supporting the development of healthy brain circuitry. Neglecting parents often fail to serve as co-regulators, which has implications for young children’s self-regulatory capabilities and brain development. As children become older, these difficulties with self-regulation may become more pronounced. Adolescence represents a period of particular vulnerability for the emergence of mental health problems because of increasing demands for regulation of emotions and behaviors, coupled with on-going development of neural circuits that support emotional and behavioral regulation. In this competing renewal, we propose to follow children into adolescence who initially participated in a randomized clinical trial design of Attachment and Biobehavioral Catch-up (ABC) as infants, allowing us to experimentally assess plasticity and modification of brain circuits and self-regulation as the result of an early intervention. The ABC intervention was designed to help parents learn to interact in responsive and sensitive ways, with the expectation that children would show enhanced ability to regulate behavior, emotions, and physiology. We assessed the efficacy of the ABC intervention among parents involved with Child Protective Services (CPS). Parents were randomized to ABC or to a control intervention. Children were followed at T1 (ages 1-4) and T2 (ages 8-10). At T1, more of the children in the ABC group developed secure and organized attachments than children in the DEF group, and children in ABC showed more normative production of cortisol, less expression of negative emotions, and stronger inhibitory control than children in DEF. ABC parents were more sensitive and showed more optimal neural activity than DEF parents. At T2, ABC children showed greater prefrontal cortex activation in response to photographs of fearful faces than DEF children, suggesting better regulation to threat at the level of brain activation. Also at T2, children in the ABC group reported more secure relationships with parents, and showed more normative cortisol production and more optimal autonomic nervous system functioning than DEF children. In adolescence, the ABC intervention is expected to result in enhanced brain circuitry and more optimal functioning relative to the control intervention. In the proposed study, we will assess behavioral and neurobiological development among 13-, 14- and 15-year-old adolescents whose parents were referred by CPS to a randomized clinical trial in infancy (n=120), and among low-risk adolescents followed since middle childhood (n=80). At each annual assessment, the primary constructs, inhibitory control, emotion regulation, physiological regulation, and attachment/affiliation, will be assessed at the level of brain activation and circuitry, and at the behavioral level.

项目摘要/摘要父母是他们的小孩的共同调节者，帮助他们调节行为，情感和生理和支持健康脑电路的发展。忽视父母常常无法担任共同调节器，这对幼儿的自我调节能力和大脑发育有影响。随着孩子的年龄增长，这些自我调节的困难可能会变得更加明显。青少年由于有一个特殊脆弱性的时期，因为对情绪和行为调节的需求不断增加，再加上神经元的持续发展支持情绪和行为调节的电路。在这种竞争的续约中，我们建议遵循儿童进入青少年，他们最初参加了依恋的随机临床试验设计和生物行为追赶（ABC）作为婴儿，使我们能够通过实验评估可塑性和修改大脑回路和自我调节是早期干预的结果。 ABC干预旨在帮助父母学习以敏感和敏感的方式进行互动，并期望孩子表现出来增强了调节行为，情绪和生理学的能力。我们评估了ABC的效率与儿童保护服务（CPS）有关的父母之间的干预。父母被随机分配给ABC或进行控制干预。儿童在T1（1-4岁）和T2（8-10岁）时受到儿童的追踪。在T1，更多 ABC组的儿童比DEF组的儿童开发了安全和有组织的附件， ABC中的儿童表现出更正常的皮质醇产生，负面情绪的表达较小，并且与DEF中的儿童相比，抑制性控制更强。 ABC父母更敏感，表现更佳神经活动比DEF父母。在T2时，ABC儿童在反应中显示出更大的前额叶皮层激活比def儿童的恐惧面孔的照片，建议在大脑级别上更好地调节威胁激活。同样在T2，ABC小组的儿童报告了与父母的更安全关系，并表明与DEF相比孩子们。在青春期，预计ABC干预将导致大脑回路增强和更多相对于控制干预的最佳功能。在拟议的研究中，我们将评估行为和 13岁，14岁和15岁的青少年之间的神经生物学发展 CP到婴儿期随机临床试验（n = 120），在低风险的青少年中，随后是中间童年（n = 80）。在每个年度评估中，主要结构，抑制性控制，情绪调节，物理调节以及附着/隶属关系将在大脑激活和电路的水平上进行评估，并处于行为层面。

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Early exposure to parent-perpetrated intimate partner violence predicts hypervigilant error monitoring.

早期接触父母实施的亲密伴侣暴力预示着过度警惕的错误监控。

DOI：
10.1016/j.ijpsycho.2022.01.006
发表时间：
2022-03
期刊：
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
影响因子：
0
作者：
Palmwood EN;Valadez EA;Zajac LA;Griffith AM;Simons RF;Dozier M
通讯作者：
Dozier M

Children's social information processing predicts both their own and peers' conversational remarks.

儿童的社交信息处理可以预测他们自己和同龄人的对话言论。

DOI：
10.1037/dev0001510
发表时间：
2023
期刊：
Developmental psychology
影响因子：
4
作者：
Hubbard,JulieA;Bookhout,MeganK;Zajac,Lindsay;Moore,ChristinaC;Dozier,Mary
通讯作者：
Dozier,Mary

Depressive symptoms and error-related brain activity in CPS-referred children.

CPS 转诊儿童的抑郁症状和错误相关的大脑活动。

DOI：
10.1111/psyp.13211
发表时间：
2018
期刊：
Psychophysiology
影响因子：
3.7
作者：
Tabachnick,AlexandraR;Valadez,EmilioA;Palmwood,ErinN;Zajac,Lindsay;Simons,RobertF;Dozier,Mary
通讯作者：
Dozier,Mary

Attachment security in infancy predicts reduced parasympathetic reactivity in middle childhood.