Intervening Early with Neglected Children: Key Behavioral and Neurobiological Outcomes in Adolescence

对被忽视的儿童进行早期干预:青春期的关键行为和神经生物学结果

基本信息

  • 批准号:
    10643830
  • 负责人:
  • 金额:
    $ 64.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-02-01 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ ABSTRACT Parents serve as co-regulators for their young children, helping them regulate behaviors, emotions, and physiology and supporting the development of healthy brain circuitry. Neglecting parents often fail to serve as co-regulators, which has implications for young children’s self-regulatory capabilities and brain development. As children become older, these difficulties with self-regulation may become more pronounced. Adolescence represents a period of particular vulnerability for the emergence of mental health problems because of increasing demands for regulation of emotions and behaviors, coupled with on-going development of neural circuits that support emotional and behavioral regulation. In this competing renewal, we propose to follow children into adolescence who initially participated in a randomized clinical trial design of Attachment and Biobehavioral Catch-up (ABC) as infants, allowing us to experimentally assess plasticity and modification of brain circuits and self-regulation as the result of an early intervention. The ABC intervention was designed to help parents learn to interact in responsive and sensitive ways, with the expectation that children would show enhanced ability to regulate behavior, emotions, and physiology. We assessed the efficacy of the ABC intervention among parents involved with Child Protective Services (CPS). Parents were randomized to ABC or to a control intervention. Children were followed at T1 (ages 1-4) and T2 (ages 8-10). At T1, more of the children in the ABC group developed secure and organized attachments than children in the DEF group, and children in ABC showed more normative production of cortisol, less expression of negative emotions, and stronger inhibitory control than children in DEF. ABC parents were more sensitive and showed more optimal neural activity than DEF parents. At T2, ABC children showed greater prefrontal cortex activation in response to photographs of fearful faces than DEF children, suggesting better regulation to threat at the level of brain activation. Also at T2, children in the ABC group reported more secure relationships with parents, and showed more normative cortisol production and more optimal autonomic nervous system functioning than DEF children. In adolescence, the ABC intervention is expected to result in enhanced brain circuitry and more optimal functioning relative to the control intervention. In the proposed study, we will assess behavioral and neurobiological development among 13-, 14- and 15-year-old adolescents whose parents were referred by CPS to a randomized clinical trial in infancy (n=120), and among low-risk adolescents followed since middle childhood (n=80). At each annual assessment, the primary constructs, inhibitory control, emotion regulation, physiological regulation, and attachment/affiliation, will be assessed at the level of brain activation and circuitry, and at the behavioral level.
项目摘要/摘要 父母是他们的小孩的共同调节者,帮助他们调节行为,情感和 生理和支持健康脑电路的发展。忽视父母常常无法担任 共同调节器,这对幼儿的自我调节能力和大脑发育有影响。 随着孩子的年龄增长,这些自我调节的困难可能会变得更加明显。青少年 由于有一个特殊脆弱性的时期,因为 对情绪和行为调节的需求不断增加,再加上神经元的持续发展 支持情绪和行为调节的电路。在这种竞争的续约中,我们建议遵循 儿童进入青少年,他们最初参加了依恋的随机临床试验设计和 生物行为追赶(ABC)作为婴儿,使我们能够通过实验评估可塑性和修改 大脑回路和自我调节是早期干预的结果。 ABC干预旨在 帮助父母学习以敏感和敏感的方式进行互动,并期望孩子表现出来 增强了调节行为,情绪和生理学的能力。我们评估了ABC的效率 与儿童保护服务(CPS)有关的父母之间的干预。父母被随机分配给ABC或 进行控制干预。儿童在T1(1-4岁)和T2(8-10岁)时受到儿童的追踪。在T1,更多 ABC组的儿童比DEF组的儿童开发了安全和有组织的附件, ABC中的儿童表现出更正常的皮质醇产生,负面情绪的表达较小,并且 与DEF中的儿童相比,抑制性控制更强。 ABC父母更敏感,表现更佳 神经活动比DEF父母。在T2时,ABC儿童在反应中显示出更大的前额叶皮层激活 比def儿童的恐惧面孔的照片,建议在大脑级别上更好地调节威胁 激活。同样在T2,ABC小组的儿童报告了与父母的更安全关系,并表明 与DEF相比 孩子们。在青春期,预计ABC干预将导致大脑回路增强和更多 相对于控制干预的最佳功能。在拟议的研究中,我们将评估行为和 13岁,14岁和15岁的青少年之间的神经生物学发展 CP到婴儿期随机临床试验(n = 120),在低风险的青少年中,随后是中间 童年(n = 80)。在每个年度评估中,主要结构,抑制性控制,情绪调节, 物理调节以及附着/隶属关系将在大脑激活和电路的水平上进行评估, 并处于行为层面。

项目成果

期刊论文数量(17)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Early exposure to parent-perpetrated intimate partner violence predicts hypervigilant error monitoring.
早期接触父母实施的亲密伴侣暴力预示着过度警惕的错误监控。
Children's social information processing predicts both their own and peers' conversational remarks.
儿童的社交信息处理可以预测他们自己和同龄人的对话言论。
  • DOI:
    10.1037/dev0001510
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    4
  • 作者:
    Hubbard,JulieA;Bookhout,MeganK;Zajac,Lindsay;Moore,ChristinaC;Dozier,Mary
  • 通讯作者:
    Dozier,Mary
Depressive symptoms and error-related brain activity in CPS-referred children.
CPS 转诊儿童的抑郁症状和错误相关的大脑活动。
  • DOI:
    10.1111/psyp.13211
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Tabachnick,AlexandraR;Valadez,EmilioA;Palmwood,ErinN;Zajac,Lindsay;Simons,RobertF;Dozier,Mary
  • 通讯作者:
    Dozier,Mary
Attachment security in infancy predicts reduced parasympathetic reactivity in middle childhood.
  • DOI:
    10.1080/14616734.2020.1741656
  • 发表时间:
    2021-10
  • 期刊:
  • 影响因子:
    3.2
  • 作者:
    Tabachnick AR;Raby KL;Goldstein A;Zajac L;Dozier M
  • 通讯作者:
    Dozier M
Prospective Associations Between Early Childhood Intimate Partner Violence Exposure and Middle Childhood Internalizing and Externalizing Psychopathology.
儿童早期亲密伴侣暴力暴露与儿童中期内化和外化精神病理学之间的前瞻性关联。
  • DOI:
    10.1177/10775595221100722
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    5.1
  • 作者:
    Lee,AmyHyoeun;Mirhashem,Rebecca;Bernard,Kristin;Dozier,Mary
  • 通讯作者:
    Dozier,Mary
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Mary Dozier其他文献

Mary Dozier的其他文献

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{{ truncateString('Mary Dozier', 18)}}的其他基金

Intervening with Opioid-Dependent Mothers Living in Poverty: Effects on Mothers' and Infants' Behavioral and Biological Regulation
对生活在贫困中的阿片类药物依赖母亲进行干预:对母亲和婴儿行为和生物调节的影响
  • 批准号:
    10383715
  • 财政年份:
    2020
  • 资助金额:
    $ 64.38万
  • 项目类别:
Intervening with Opioid-Dependent Mothers Living in Poverty: Effects on Mothers' and Infants' Behavioral and Biological Regulation
对生活在贫困中的阿片类药物依赖母亲进行干预:对母亲和婴儿行为和生物调节的影响
  • 批准号:
    10610855
  • 财政年份:
    2020
  • 资助金额:
    $ 64.38万
  • 项目类别:
Early intervention for children adopted internationally
对国际收养儿童的早期干预
  • 批准号:
    8391761
  • 财政年份:
    2009
  • 资助金额:
    $ 64.38万
  • 项目类别:
Early intervention for children adopted internationally
对国际收养儿童的早期干预
  • 批准号:
    8197082
  • 财政年份:
    2009
  • 资助金额:
    $ 64.38万
  • 项目类别:
Early intervention for children adopted internationally
对国际收养儿童的早期干预
  • 批准号:
    7749549
  • 财政年份:
    2009
  • 资助金额:
    $ 64.38万
  • 项目类别:
Early intervention for children adopted internationally
对国际收养儿童的早期干预
  • 批准号:
    7998217
  • 财政年份:
    2009
  • 资助金额:
    $ 64.38万
  • 项目类别:
Early intervention for children adopted internationally
对国际收养儿童的早期干预
  • 批准号:
    7591311
  • 财政年份:
    2009
  • 资助金额:
    $ 64.38万
  • 项目类别:
Specialized services for high-risk birth parents
为高危亲生父母提供专业服务
  • 批准号:
    7336361
  • 财政年份:
    2006
  • 资助金额:
    $ 64.38万
  • 项目类别:
Specialized services for high-risk birth parents
为高危亲生父母提供专业服务
  • 批准号:
    7539205
  • 财政年份:
    2006
  • 资助金额:
    $ 64.38万
  • 项目类别:
Intervening Early with Neglected Children: Key Middle Childhood Outcomes
对被忽视的儿童进行早期干预:童年中期的关键成果
  • 批准号:
    8729787
  • 财政年份:
    2006
  • 资助金额:
    $ 64.38万
  • 项目类别:

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  • 批准号:
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  • 批准年份:
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益生菌治疗青少年抑郁症
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青少年间歇性饮酒后中枢神经系统介导的发热
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