Investigating substance use, minority stress, and inflammation among sexual and gender minority participants in the All of Us Research Program

调查“我们所有人研究计划”中性少数和性别少数参与者的药物使用、少数群体压力和炎症

• 批准号: 10643426
• 负责人: Annesa Flentje
• 金额: $ 12.11万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10643426
• 关键词: Alcohol consumption; All of Us Research Program; Award; Baseline Surveys; Biological; Biological Process; Birth; C-reactive protein; Cardiovascular Diseases; Cessation of life; Chronic stress; Clinical; DNA Methylation; Data; Discrimination; Epigenetic Process; Gender; HIV; Health; Health behavior; Heterosexuals; Immune; Incidence; Inflammation; Inflammatory; Injury; Lesbian Gay Bisexual Transgender Queer; Measures; Mental disorders; National Institute of Drug Abuse; Outcome; Parents; Participant; Pathway interactions; Pattern; Persons; Population; Prevention; Prospective cohort study; Reporting; Research; Risk; Sampling; Sexual and Gender Minorities; Stress; Subgroup; Substance Use Disorder; Time; United States; Woman; Work; base; biomarker development; cis-female; cis-male; cisgender; clinical biomarkers; cohort; comorbidity; disability; epigenetic marker; expectation; experience; gender minority; gender minority group; health disparity; improved; inflammatory marker; interest; internalized stigma; maltreatment; marijuana use; men; minority stress; nicotine use; non-heterosexual; perceived discrimination; polysubstance use; prevent; prospective; respiratory; response; sex; sexual minority; social determinants; social health determinants; social stigma; substance use; substance use treatment; transgender; transgender men; transgender women

PROJECT SUMMARY/ABSTRACT Sexual minority (SM, i.e., people who are not heterosexual) and gender minority (GM, i.e., people who have a gender that is discordant from the sex they were assigned at birth, as opposed to cisgender people who have a gender that is concordant with the sex they were assigned at birth) people (collectively abbreviated as SGM) are at greater risk for health disparities including very high rates of substance use. Within studies on substance use, GM people are largely unrepresented as GM status is rarely measured or reported. The primary explanation for the higher rates of substance use and health problems among SGM people is minority stress, which confers an additional stress burden on SGM people including experiences of discrimination, expectations of discrimination, concealment of one’s identity, and internalization of social stigma. Biological changes can occur in response to both minority stress and substance use, including activation of inflammatory pathways. Understanding biological correlates of substance use and minority stress may help us to develop better ways to identify and treat substance use disorders and to understand the downstream health outcomes of SGM people. This study will leverage the All of Us Research Program, a national study aiming to collect data from 1 million people within the United States, with strong representation of SGM participants. We will examine differences in substance use between SGM subgroups, examine relationships between minority stress and substance use patterns, and identify how substance use, minority stress, and HIV status are related to C-reactive protein (a marker of inflammation). This study will help us to better understand substance use among SGM people and inform how minority stress, substance use, and HIV may interact to alter inflammatory pathways. This study will also inform the development of biomarkers for substance use to improve substance use treatment and prevention.

项目摘要/摘要 性少数民族（SM，即不是异性恋者）和性别少数群体（GM，即有一个有一个的人 与他们在出生时分配的性别不一的性别，而不是具有 与他们出生时分配的性别一致的性别）人（统称为SGM）是 健康差异的风险更大，包括非常高的物质使用率。在有关药物使用的研究中， 通用汽车人很少衡量或报告，大多数人没有代表性。主要解释 SGM人群中较高的药物使用率和健康问题的率是少数派压力，它承认 对SGM人员的额外压力Burnen，包括歧视经历，歧视期望， 隐瞒自己的身份和社会污名的内在化。生物学变化可能是因为 少数压力和物质使用，包括激活炎症途径。了解生物学 药物使用和少数族裔压力的相关性可能有助于我们开发更好的方法来识别和治疗 药物使用障碍并了解SGM人的下游健康结果。 这项研究将利用我们所有的研究计划，一项国家研究旨在收集一百万的数据 美国境内的人，有力地代表了SGM参与者。我们将研究 SGM亚组之间的物质使用，检查少数族裔压力与使用物质之间的关系 模式，并确定物质使用，少数胁迫和HIV状态如何与C反应蛋白有关（A 炎症标记）。这项研究将帮助我们更好地了解SGM人中的物质使用以及 告知少数族裔压力，使用物质和HIV如何相互作用以改变炎症途径。这项研究会 还要告知生物标志物的开发，以改善药物使用治疗和 预防。