Mentoring the next generation of substance use, HIV, and epigenetic researchers in sexual and gender minority health

指导下一代性和性别少数健康领域的药物滥用、艾滋病毒和表观遗传学研究人员

• 批准号: 10699933
• 负责人: Annesa Flentje
• 金额: $ 19.71万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10699933
• 关键词: Acceleration; Accounting; Age; Aging; All of Us Research Program; American; Animal Model; Applications Grants; Area; Award; Behavioral Sciences; Bioinformatics; Biological; Biological Markers; Biology; California; Cessation of life; Clinical Psychology; Cohort Studies; Community Health Systems; Consent; Data; Data Set; Discipline; Discrimination; Emotional; Environment; Epigenetic Process; Estrogens; Faculty; Foundations; Funding; Gender; Goals; Gonadal Hormones; HIV; Health; Heterosexuals; Hormonal; Hormones; Human; Hydrocortisone; Immune response; Injury; K-Series Research Career Programs; Lesbian Gay Bisexual Transgender Queer; Longitudinal cohort study; Measures; Mentors; Mentorship; Metabolic; Modeling; Molecular Profiling; Outcome; Ovariectomy; Participant; Persons; Phenotype; Progesterone; Proxy; Psychiatry; Reproducibility; Research; Research Personnel; Resources; Risk; Safety; Sampling; San Francisco; Sexual and Gender Minorities; Stress; Structure; Surveys; Testing; Testosterone; Training; Training Programs; United States; United States National Institutes of Health; Universities; Variant; Work; career; cisgender; comorbidity; disability; epigenetic marker; epigenome; epigenomics; family building; gender affirming hormones; gender minority group; gender minority health; health disparity; improved; innovation; interest; marijuana use; mid-career faculty; minority stress; minority stressor; molecular marker; next generation; non-heterosexual; nonbinary; patient oriented; phenotypic biomarker; physical conditioning; programs; research study; response; sex; sex assigned at birth; sexual minority men; skills; social stigma; stressor; substance use; substance use treatment; systematic review; transgender

ABSTRACT Dr. Annesa Flentje is Associate Professor in Community Health Systems and Department of Psychiatry and Behavioral Sciences at the University of California, San Francisco. She mentors early career researchers in sexual and gender minority (SGM, non-heterosexual and transgender or gender non-binary people, respectively) health, focusing on substance use, minority stress, and epigenomic markers of substance use. SGM people have greater substance use when compared to their cisgender, heterosexual counterparts. The greater rates of substance use are attributed to minority stress exposure (unique stress burden due to discrimination and stigma among SGM people), and substance use increases in the presence of minority stress. Further, unique molecular profiles of both substance use and minority stress have been observed in sexual minority men living with HIV, suggesting that alterations in the epigenome may serve as biological markers for substance use. Unfortunately, research to date is limited because these models have not explicitly compared people living with HIV (PLWH) and people living without HIV (PLWoH). Further, SGM people have unique hormonal exposures that have been unaccounted for in research investigating substance use and potential epigenetic biomarkers for substance use and these hormonal exposures may also be related to alterations in the epigenome. This project will expand Dr. Flentje’s research program to integrate hormonal exposures and HIV status, to be able to identify epigenomic markers of substance use in the presence of endogenous and exogenous hormone exposures comparing PLWH to PLWoH. To support expansion of her research, Dr. Flentje will receive additional training in HIV, hormone exposures, dominance analysis, and epigenetic bioinformatics analysis. This K24 will support Dr. Flentje in mentoring patient-oriented researchers in SGM health who will leverage survey and epigenetic data from existing cohort studies: The PRIDE Study, the MACS/WIHS Combined Cohort Study, and the All of Us Research Program to 1) understand key minority stress predictors of substance use among SGM people and compare the relative strength of these predictors between PLWH and PLWoH; 2) identify endogenous and exogenous hormonal predictors of substance use among SGM people and determine differences in the relative strength of these predictors among PLWH and PLWoH; and 3) derive minority stress, substance use, and hormonal phenotypes among SGM people, identify epigenetic markers of these phenotypes, and identify differences in these epigenetic markers between PLWH and PLWoH. This K24 will support mentorship of early career researchers in SGM health focusing on substance use, HIV, hormonal biology, epigenomics, and minority stress. It will also expand Dr. Flentje’s mentorship skills to integrate structures to support mentees in navigating financial challenges, loan repayment applications, family building, and emotional hardships. As substance use research among SGM people is an emerging area of study, a national approach to mentorship to promote innovation in patient-centered research is critical.

抽象的 Annesa Flentje博士是社区卫生系统和精神病学系的副教授， 加州大学旧金山分校的行为科学。她指导早期职业研究人员 性别和性别少数（SGM，非异性恋和变性者或性别非二进制人） 健康，专注于药物使用，少数族裔压力和使用物质使用的表观标记。 SGM人 与其cisgender，异性恋对应物相比，具有更大的主题使用。较高的速度 物质使用归因于少数族裔压力暴露（由于歧视和污名引起的独特的压力燃烧 在SGM人中），在存在少数族裔压力的情况下，使用物质使用会增加。此外，独特的分子 在艾滋病毒的性少数族裔男性中都观察到了药物使用和少数族裔压力的特征， 表明表观基因组的改变可以用作使用物质的生物标记。很遗憾， 迄今为止的研究受到限制，因为这些模型尚未明确比较感染艾滋病毒（PLWH）的人 和没有艾滋病毒（PLWOH）的人。此外，SGM的人有独特的激素暴露 在研究研究物质和潜在的表观遗传生物标志物的研究中未划分的物质使用物质 这些马匹暴露也可能与表观基因组的改变有关。该项目将扩大博士。 Flentje的研究计划旨在整合荷尔蒙暴露和艾滋病毒状况，以识别表观基因组学 在存在内源性和外源激素暴露的情况下使用PLWH的物质使用标记 到plwoh。为了支持她的研究的扩展，Flentje博士将接受艾滋病毒的额外培训 暴露，优势分析和表观遗传学生物信息学分析。这个K24将支持Flentje博士 指导以患者为导向的SGM Health研究人员，他们将利用现有的调查和表观遗传数据 队列研究：骄傲研究，MAC/WIHS组合队列研究以及我们所有人的研究计划 到1）了解SGM人员中物质使用的关键少数族裔压力预测因素并比较亲戚 PLWH和PLWOH之间的这些预测因子的强度； 2）识别内源性和外源激素 SGM人员中物质使用的预测指标，并确定这些相对强度的差异 PLWH和PLWOH之间的预测因素； 3）得出少数族裔压力，使用物质和荷尔蒙表型 在SGM人中，确定这些表型的表观遗传标记，并确定这些表型的差异 PLWH和PLWOH之间的表观遗传标记。这个K24将支持早期职业研究人员的心态 在SGM健康中，重点是吸毒，HIV，Horseal生物学，表观基因组学和少数族裔压力。它也会 扩大Flentje博士的心态技能，以整合结构，以支持NANIS在航行财务中 挑战，还款申请，家庭建设和情感困难。作为药物使用研究 在SGM People中，是一个新兴领域 以患者为中心的研究至关重要。