Institutional Career Development Core

机构职业发展核心

• 批准号: 10641960
• 负责人: LLOYD G CANTLEY
• 金额: $ 131.87万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641960
• 关键词: Academia; Address; Applied Research; Area; Arts; Big Data; Bioethics; Bioinformatics; Clinical; Clinical Research; Clinical Trials; Competence; Complex; Development; Discipline; Discipline of Nursing; Doctor of Medicine; Education; Educational Curriculum; Engineering; Faculty; Feedback; Funding; Good Clinical Practice; Grant; Health; Health Sciences; Healthcare; Healthcare Systems; Industry; Institution; Interdisciplinary Study; Laboratory Research; Leadership; Learning; Logic; Machine Learning; Medical Education; Mentors; Mentorship; Modeling; Pathway Analysis; Positioning Attribute; Preparation; Public Health; Publications; Qualifying; Research; Research Personnel; Running; Scholars Program; Science; Shapes; Social Network; Talents; Training; Translational Research; United States National Institutes of Health; Universities; Work; Writing; burden of illness; career; career development; community based participatory research; curriculum enhancement; diversity and inclusion; experience; externship; health disparity; implementation science; improved; medical schools; multidisciplinary; next generation; peer coaching; programs; success; translational scientist

The KL2 Mentored Clinical Scholars Program attracts a diverse group of highly talented junior faculty across multiple disciplines from across Yale University (Schools of Medicine, Nursing, Public Health, Faculty of Arts and Sciences, Engineering and Applied Science) who will pursue careers in T1-T4 translational research. This Program has been extremely successful, attracting 151 Scholars who have authored >5200 publications, have been PIs on 258 NIH grants, and have received a total of $557 million in grant funding. Remarkably, 99% of our KL2 Scholars have attained positions in academia, industry or public health conducting, and often with leadership responsibilities for, clinical and translational research. We aim to build on this success by providing Scholars with individualized, competency-based training in translational research that prepares them to contribute to the learning healthcare system, to advance personalized health, and to address health disparities. This preparation includes training in clinical trials, big data, machine learning, bioinformatics, multidisciplinary translational research, team science, implementation science and community-based participatory research. It also introduces them to regulatory issues, bioethics, Good Clinical Practices, and factors that drive rigor, transparency, and replicability. The KL2 promotes the development of relevant competencies among the Scholars by providing: 1) opportunities to work successfully in complex and diverse multidisciplinary research teams, 2) access to mentorship by senior mentors and recent Clinical Scholars, 3) externships in industry, public health and regulatory agencies, and 4) intensive training in grant-writing and in multidisciplinary team science. To oversee these diverse, highly motivated junior investigators, we have an educational leadership team of: 1) three outstanding investigator mentors who work in different areas of translational research, 2) an experienced Diversity Officer, and 3) an expert in evaluating and dynamically reshaping medical education programs. This leadership team has used feedback from prior Scholars and their mentors to add new initiatives to the already successful program. We expanded our logic model to implement social network analyses to track the activities of the Scholars, and we will expand the curriculum to include a new course. That course will mix Scholars and TL-1 trainees who will work in teams as they get formal training and peer mentoring in a variety of areas such as big data/machine learning, diversity and inclusion, and running a research laboratory. With these additions to an already strong curriculum, we believe that the Yale Mentored Clinical Scholars Program will be ideally positioned to train the next generation of leaders in T1-T4 translational research who will transform healthcare in ways that alleviate the burden of disease and improve health in the US and around the world. The Specific Aims of the KL2 are: Aim 1: The Yale Mentored Clinical Scholars Program: To provide a program comprised of a mentored research experience, coursework, and seminars that are intended to promote the emergence of scientific independence and the career development of talented young T1-T4 translational scientist Scholars. Aim 2: The Yale Masters in Health Science Program: To provide those M.D. Scholars who do not possess an advanced research degree with additional coursework and scholarly activities to qualify for a Masters in Health Science (MHS) to address limitations in their scientific preparation for a research career.

KL2 指导临床学者计划吸引了来自不同国家和地区的一批才华横溢的初级教师 耶鲁大学多个学科（医学院、护理学院、公共卫生学院、文学院） 以及科学、工程和应用科学），他们将从事 T1-T4 转化研究职业。这 该计划非常成功，吸引了 151 名学者，他们撰写了超过 5200 份出版物， 是 258 项 NIH 资助项目的 PI，并已获得总计 5.57 亿美元的资助资金。值得注意的是，99% 我们的 KL2 学者已在学术界、工业界或公共卫生领域担任职务，并且经常与 临床和转化研究的领导职责。我们的目标是通过提供 接受过个性化、基于能力的转化研究培训的学者，使他们做好准备 为学习医疗保健系统做出贡献，促进个性化健康，并解决健康差距。 该准备工作包括临床试验、大数据、机器学习、生物信息学、多学科培训 转化研究、团队科学、实施科学和基于社区的参与性研究。它 还向他们介绍监管问题、生物伦理学、良好临床实践以及推动严格性的因素， 透明度和可复制性。 KL2 促进相关能力的发展 学者们通过提供：1）在复杂多样的多学科研究中成功工作的机会 团队，2) 获得高级导师和近期临床学者的指导，3) 行业实习， 公共卫生和监管机构，以及 4) 拨款写作和多学科团队的强化培训 科学。为了监督这些多元化、积极性高的初级研究人员，我们有一个教育领导层 团队成员：1) 三位在转化研究不同领域工作的杰出研究者导师，2) 一位 经验丰富的多元化官员，以及 3) 评估和动态重塑医学教育的专家 程序。该领导团队利用先前学者及其导师的反馈来添加新举措 到已经成功的计划。我们扩展了逻辑模型以实施社交网络分析 跟踪学者的活动，我们将扩展课程以包括一门新课程。该课程将 混合学者和 TL-1 学员，他们将在接受正式培训和同伴指导时进行团队合作 各种领域，如大数据/机器学习、多样性和包容性，以及运营研究实验室。 通过对本已强大的课程进行这些补充，我们相信耶鲁大学指导临床学者 该计划将非常适合培训 T1-T4 转化研究领域的下一代领导者 将以减轻疾病负担和改善美国及周边地区健康的方式改变医疗保健 世界。 KL2 的具体目标是： 目标 1：耶鲁指导临床学者计划：提供一个由指导临床学者组成的计划 旨在促进科学发展的研究经验、课程和研讨会 有才华的年轻T1-T4转化科学家学者的独立性和职业发展。 目标 2：耶鲁大学健康科学硕士项目：为那些不具备健康科学硕士学位的医学博士学者提供 高级研究学位以及额外的课程和学术活动，以获得硕士学位 健康科学 (MHS) 旨在解决研究生涯科学准备方面的局限性。

项目成果

Treatment of toxic epidermal necrolysis and concurrent COVID-19-associated hyperinflammatory syndrome with systemic corticosteroids and etanercept.

• DOI: 10.1016/j.jdcr.2022.09.009
• 发表时间: 2022-11
• 期刊: JAAD case reports
• 作者: Choi, Rachel;Garritano, James;Laird, Mary;Johnston, Margaret;Tkachenko, Elizabeth;Damsky, William;Little, Alicia J;McNiff, Jennifer;Girardi, Michael;Nelson, Caroline A
• 通讯作者: Nelson, Caroline A

The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex.

放射孤立综合征儿童的诊断检查因年龄和性别而异。

• DOI: 10.1007/s00415-024-12289-1
• 发表时间: 2024
• 期刊: Journal of neurology
• 影响因子: 6
• 作者: Makhani,Naila;Lebrun-Frenay,Christine;Siva,Aksel;Shabanova,Veronika;Wassmer,Evangeline;Santoro,JonathanD;Narula,Sona;Brenton,JNicholas;Mar,Soe;Durand-Dubief,Francoise;Zephir,Helene;Mathey,Guillaume;Rojas,JuanI;deSeze,Jerome

Automatic detection of prominent interictal spikes in intracranial EEG: validation of an algorithm and relationsip to the seizure onset zone.

• DOI: 10.1016/j.clinph.2013.10.021
• 发表时间: 2014-06
• 期刊: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
• 作者: Gaspard N;Alkawadri R;Farooque P;Goncharova II;Zaveri HP
• 通讯作者: Zaveri HP

PACS-Integrated Tools for Peritumoral Edema Volumetrics Provide Additional Information to RANO-BM-Based Assessment of Lung Cancer Brain Metastases after Stereotactic Radiotherapy: A Pilot Study.

• DOI: 10.3390/cancers15194822
• 发表时间: 2023-09-30
• 期刊: CANCERS
• 影响因子: 5.2
• 作者: Kaur, Manpreet;Petersen, Gabriel Cassinelli;Jekel, Leon;von Reppert, Marc;Varghese, Sunitha;Santo, Irene Dixe de Oliveira;Avesta, Arman;Aneja, Sanjay;Omuro, Antonio;Chiang, Veronica;Aboian, Mariam
• 通讯作者: Aboian, Mariam

Impairment of consciousness induced by bilateral electrical stimulation of the frontal convexity.

• DOI: 10.1016/j.ebcr.2017.09.006
• 发表时间: 2017
• 期刊: Epilepsy & behavior case reports
• 作者: Quraishi IH;Benjamin CF;Spencer DD;Blumenfeld H;Alkawadri R
• 通讯作者: Alkawadri R