Pathology Network Shared Resource

病理网络共享资源

• 批准号: 10641718
• 负责人: CARL D MORRISON
• 金额: $ 25.35万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-16 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10641718
• 关键词: African American; Area; Basic Science; Biological Markers; Biological Specimen Banks; Breast Carcinoma; Cancer Center Support Grant; Cells; Clinical; Clinical Protocols; Clinical Trials; Collection; Complement; Comprehensive Cancer Center; Consent; Correlative Study; DNA; Data; Data Analyses; Development; Disease; Disease Resistance; Disseminated Malignant Neoplasm; Elements; Freezing; Fresh Tissue; Funding; Future; Genomics Shared Resource; Goals; Grant; Grant Review; Health Service Area; Hematologic Neoplasms; Histology; Human; Image Analysis; Immune; Immunohistochemistry; Immunology; Individual; Industry; Institutional Review Boards; Ischemia; Laboratories; Lead; Leadership; Legal; Malignant Neoplasms; Malignant neoplasm of lung; Methods; Mission; Modeling; Operative Surgical Procedures; Pathogenesis; Pathology; Patients; Peer Review; Play; Preparation; Prevention; Process; Protocols documentation; RNA; Recurrence; Recurrent disease; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Resources; Role; Sampling; Scanning; Science; Services; Site; Slide; Smoker; Solid Neoplasm; Specimen; Spectral Karyotyping; Standardization; System; Technology; The Cancer Genome Atlas; Time; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; Tumor Tissue; Visualization; Work; automated image analysis; biobank; biomarker discovery; biomarker panel; biomedical data science; cancer therapy; cell type; cohort; cost; data repository; design; functional status; implementation facilitation; instrumentation; laser capture microdissection; liquid crystal polymer; malignant breast neoplasm; member; non-smoker; operation; precision medicine; sample collection; spatial relationship; spectrograph; symposium; therapy resistant; tool; tumor

The Pathology Network Shared Resource (PNSR) provides human specimens and laboratory services for basic and translational research to further the understanding of the pathogenesis of human cancers and facilitate discovery of biomarkers for new precision medicine approaches. The overall mission of the PNSR is to facilitate collection and access to bio-specimens for research conducted at Roswell Park Comprehensive Cancer Center. The PNSR provides five key service areas: Procurement, Pathology Core Services, Correlative Science Pathology Office, Bio-specimen Bank, and Image Analysis. In the reporting period (2013-2017), the PNSR served a total of 202 Roswell users, of which 131 (88%) were CCSG members. The Specific Aims of the PNSR are: 1) To consent, collect, and store high quality tumor bio specimens. The PNSR oversees the consenting and collection of tumor specimens under a highly standardized process with IRB approval. This includes both routine surgical collections as well as specialized collections of metastatic disease, fresh tissue, or longitudinal collections in accordance with specific clinical protocols; 2) To provide state-of-the-art tissue analyses platforms. The PNSR provides a robust suite of tissue analysis tools to enable the comprehensive analysis of tissues. Standard histology and immunohistochemistry services are complemented by laser capture microdissection and spectral karyotyping; 3) To provide expertise for study design, grant preparation, and clinical trials. Staff within the PNSR plays an active role in designing biomarker studies and rigorous methods for evaluating data that emerges from the analysis of tissues. These integrated features of the PNSR provide an important platform for grant submissions and facilitate development of correlative studies in the context of clinical trials. There are limited options for bio specimen acquisition with the level of quality and annotation that is provided by the PNSR. Acquiring fresh or frozen tissue from external tissue banks is costly, requires considerable legal work (e.g. MTAs), and reliability can be questionable, our costs for these activities in comparison to external sites provide more affordable service for CCSG members. Furthermore, the convenience of these resources is an added benefit to investigators in terms of saving them time and ease of discussion related to design and interpretation of data. Services within the PNSR are accessible to any researcher that has appropriate IRB approval for the proposed work. The PNSR plans to be at the forefront in all areas of operation to facilitate cutting-edge research that will lead to significant changes in the prevention and treatment of cancer. Specialized procurement is critical for this goal given the importance of understanding metastatic, recurrent, and therapy resistant disease.

病理网络共享资源（PNSR）为人类标本和实验室服务 基础和翻译研究，以进一步了解人类癌症的发病机理 促进针对新的精密医学方法发现生物标志物。 PNSR的整体任务是 为了促进在罗斯威尔公园综合进行研究的收集和访问生物规范的研究 癌症中心。 PNSR提供五个关键服务领域：采购，病理学核心服务，相关性 科学病理办公室，生物特异性银行和图像分析。在报告期（2013-2017）中， PNSR总共服务了202名罗斯韦尔用户，其中131名（88％）是CCSG成员。具体目的 PNSR是：1）同意，收集和存储高质量的肿瘤生物标本。 PNSR监督 在高度标准化的过程中，同意和收集IRB批准的肿瘤标本。这 包括常规手术收集以及转移性疾病，新鲜组织的专门收集， 或根据特定的临床方案的纵向收集； 2）提供最先进的组织 分析平台。 PNSR提供了强大的组织分析工具，以实现全面 组织分析。标准的组织学和免疫组织化学服务由激光补充 捕获微分解和光谱核分型； 3）为研究设计提供专业知识，赠款准备， 和临床试验。 PNSR中的员工在设计生物标志物研究和严格的研究中起着积极的作用 评估从组织分析中出现的数据的方法。 PNSR的这些集成特征 为赠款提交提供一个重要的平台，并促进相关研究的发展 临床试验的背景。生物标本获取的选择有限，质量水平和 PNSR提供的注释。从外部组织库中获取新鲜或冷冻的组织是昂贵的， 需要大量的法律工作（例如MTA），可靠性可能是可疑的，我们为这些活动的费用 与外部站点相比，为CCSG成员提供了更多负担得起的服务。此外， 这些资源的便利性是调查人员节省时间和便利的额外好处 与数据的设计和解释有关的讨论。 PNSR中的服务可访问 对拟议工作获得适当批准的IRB批准的研究人员。 PNSR计划处于最前沿 所有运营领域，以促进最先进的研究，这将导致预防的重大变化 和癌症的治疗。鉴于重要性，专业采购对于这个目标至关重要 了解转移，复发和抗治疗疾病。