Training Grant on the Biology of Aging

衰老生物学培训补助金

基本信息

批准号：
10640877
负责人：
PETER J HORNSBY
金额：
$ 12.28万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10640877
关键词：
Biology of Aging Grant Training

项目摘要

SUMMARY For the past three decades, the University of Texas Health Science Center at San Antonio (UTHSCSA) has hosted a premier Training Program in the biology of aging that has resulted in the development of a new generation of leaders in this field. This application seeks to continue this T32 Training Program and we request funds to support four predoctoral and four postdoctoral trainees. In this funding period, we are building on our unparalleled record of success and expand the program to prepare trainees in the emerging area of Geroscience, term that encompasses (1) fundamentals of basic aging biology; (2) the relationship between aging biology and the etiology of age-related disease; and (3) principles of translational research in biological aging. Our overarching objective is to catalyze development of interventions that modulate the aging process, leading to an extension of healthspan. The achievement of this goal requires a cadre of dedicated young researchers who have received multi-disciplinary training. Thus, this T32 Training Program aims to attract outstanding young scientists and train them in a vibrant and collaborative environment rich in Geroscience resources. The Training Program involves 48 faculty members and takes advantage of the synergies created by their intense collaborations across 7 departments. Our Geroscience training environment is second to none, and features the Barshop Institute, a Nathan Shock Center, our new Claude D. Pepper Center, a Geriatric Research, Education and Clinical Center, and the Interventions Testing Program. Since 1988, this T32 has trained many outstanding researchers in Geroscience, including current members of the current T32 Faculty. Our former trainees have been awarded numerous federal grants (including F, K and R series awards), and include Assistant or Associate Professors. Drs. Nicolas Musi, Peter Hornsby and Veronica Galvan will co-direct this Program and are supported by an Internal Steering Committee and an External Advisory Committee. The Faculty expertise crosses the spectrum of aging biology (inflammation, senescence, metabolism, epigenetics, macromolecular damage, proteostasis, stem cells); genesis of age-related diseases (cancer, diabetes, Alzheimer's disease, osteoporosis, sarcopenia); and early-phase translational research. The principal components of the Training Program are: (1) participation with graded responsibility in the laboratory of an experienced investigator; (2) commitment to collaboration and the use of multidisciplinary research approaches; (3) continuing research-in-progress seminars; (4) integrated lecture/journal club series on Geroscience; (5) courses and seminars in the responsible conduct of research, scientific communication, grantsmanship and peer review; (6) a rigorous group mentoring design; (7) preparation of an individual development plan and comprehensive evaluation of trainee progress; (8) continued evaluation and teaching of mentoring skills for faculty preceptors; and (9) active recruitment of meritorious trainees and faculty preceptors to reflect workforce ethnic/racial diversity. Trainee access to on-going departmental conferences, clinical rounds and courses further enhances the training experience.

概括在过去的三十年中，圣安东尼奥大学健康科学中心（UTHSCSA）拥有主持了衰老生物学的主要培训计划，这导致了新的发展该领域的领导者产生。该申请旨在继续该T32培训计划，我们要求资金支持四名五名和四名博士后学员。在这个资金期间，我们正在建立我们的基础无与伦比的成功记录并扩展了该计划，以准备在Geroscience新兴领域的受训者，包括（1）基本衰老生物学的基本原理的术语；（2）衰老生物学与与年龄有关的疾病的病因；（3）生物衰老的转化研究原理。我们的总体目标是促进调节衰老过程的干预措施的发展，导致扩展健康范围。实现这一目标需要一群专门的年轻研究人员已经接受了多学科培训。因此，该T32培训计划旨在吸引出色的年轻人科学家并在充满活力和合作的环境中培训他们，富含Geroscience资源。培训计划涉及48位教职员工，并利用其强度创造的协同作用跨7个部门的合作。我们的Geroscience培训环境首屈一指，并具有 Barshop Institute，Nathan Shock Center，我们的新Claude D. Pepper Center，一项老年研究，教育和临床中心以及干预措施测试计划。自1988年以来，该T32培训了许多出色的 Geroscience的研究人员，包括当前T32教职员工的现任成员。我们的前学员有被授予了许多联邦赠款（包括F，K和R系列奖），包括助理或同事教授。博士。 Nicolas Musi，Peter Hornsby和Veronica Galvan将共同指导该计划并得到支持由内部指导委员会和外部咨询委员会组成。教师专业知识跨越衰老生物学的光谱（炎症，衰老，代谢，表观遗传学，大分子损伤，蛋白质，干细胞）；年龄相关疾病的起源（癌症，糖尿病，阿尔茨海默氏病，骨质疏松症，肌肉减少症）；和早期翻译研究。培训计划的主要组成部分是：（1）参与经验丰富的研究人员的实验室的分级责任；（2）承诺合作和使用多学科研究方法；（3）继续进行研究研讨会；（4）关于Geroscience的综合讲座/期刊俱乐部系列；（5）负责的课程和研讨会进行研究，科学沟通，授予技巧和同行评审；（6）严格的团体指导设计; （7）制定个人发展计划和对学员进步的全面评估；（8）继续评估和教学技能的教师教育者；（9）积极招募出色的学员和教师主持人，以反映劳动力种族/种族多样性。实习生进入正在进行的部门会议，临床回合和课程进一步增强了培训经验。

项目成果

期刊论文数量（70）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis.

DOI：
10.1371/journal.pone.0015864
发表时间：
2011-01-10
期刊：
PloS one
影响因子：
3.7
作者：
Ravi D;Chen Y;Karia B;Brown A;Gu TT;Li J;Carey MS;Hennessy BT;Bishop AJ
通讯作者：
Bishop AJ

PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts.

DOI：
10.1038/cdd.2009.150
发表时间：
2010-04
期刊：
CELL DEATH AND DIFFERENTIATION
影响因子：
12.4
作者：
Matheny, R. W., Jr.;Adamo, M. L.
通讯作者：
Adamo, M. L.

Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels.

DOI：
10.1016/j.bbrc.2012.05.055
发表时间：
2012-06-08
期刊：
Biochemical and biophysical research communications
影响因子：
3.1
作者：
Lustgarten MS;Bhattacharya A;Muller FL;Jang YC;Shimizu T;Shirasawa T;Richardson A;Van Remmen H
通讯作者：
Van Remmen H

ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair.