Training Program in Personalized Cardiovascular Medicine (TPIPCVM)

个性化心血管医学培训计划 (TPIPCVM)

基本信息

批准号：
10454147
负责人：
Dawood Darbar
金额：
$ 40.29万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10454147
关键词：
Cardiovascular system Medicine Training Programs

项目摘要

TRAINING IN PERSONALIZED CARDIOVASCULAR MEDICINE (TPIPCVM) Project Summary Cardiovascular disease (CVD) remains a major cause for significant morbidity and mortality in the U.S. especially in ethnic minorities with their high burden of risk factors. Personalized medicine is a rapidly growing field of healthcare whereby an individual's unique genomic, environmental and clinical background is analyzed to ascertain susceptibility to disease, predict their clinical course and tailor specific therapies. Despite recent advances in CV genomics, our inability to target therapy to underlying mechanisms in individual patients, the failure to translate these scientific discoveries to the bedside care of patients and barriers to the incorporation of ethnic minorities in translational CV research have limited our ability to fulfill the promise of personalized medicine. Furthermore, traditional training programs are no longer able to provide trainees with the requisite skills needed to implement the personalized medicine revolution underway. Thereby, major goals of the Training Program in Personalized Cardiovascular Medicine (TPIPCVM) are to equip trainees to become leaders in CV Genomics and be trained in molecular, cellular, disease and whole animal modeling and clinical and translational approaches to CVD so that this new knowledge can be translated into best evidence-based personalized CV care. We will recruit highly talented and motivated pre- and post-doctoral trainees and provide them with the highest caliber training in CV genomics stemming from existing strengths of our faculty in the Division of Cardiology and our partners at UIC. The 3 Research Focus Groups: 1) Cardiac arrhythmias; 2) Ischemic and non-ischemic cardiomyopathy; and CVD-related metabolic syndrome are highly interrelated with each other and directly linked with the central theme of Personalized CV Genomics. The overarching goal of the TPIPCVM is to train the next generation of CV investigators to create new knowledge and implement into best evidence-based personalized medicine. The TPIPCVM mentors are highly successful physician-scientists/scientists with a proven record of research, mentoring and collaboration who offer superb inter- and multi- disciplinary training opportunities. Major strengths of this training program include: exposure of trainees to an integrated basic science molecular, cellular, and whole patient approach to identify the underlying mechanisms of CVD; the track record of the faculty and their common research interest in Personalized CV Genomics; dedicated training in personalized CV medicine; and the potential to implement scientific discoveries to a diverse and under-represented population of patients cared for at UIC Medical Center. The TPIPCVM sets out to train 2 pre-doctoral and 2 post-doctoral students annually. Collectively, this Training Program offers a unique training experience and fulfills an urgent need for training in personalized CV medicine.

个性化心血管医学培训（TPIPCVM）项目摘要心血管疾病（CVD）仍然是导致明显发病率和死亡率的主要原因美国，尤其是在少数民族中，其危险因素负担很高。个性化药物是迅速发展的医疗领域，个人的独特基因组，环境和临床分析背景以确定对疾病的敏感性，预测其临床过程并量身定制具体疗法。尽管CV基因组学最近取得了进步，但我们无法将治疗靶向个别患者的基本机制，未能将这些科学发现转化为患者的床旁护理和限制少数民族在转化简历中的障碍研究限制了我们实现个性化医学承诺的能力。此外，传统培训计划不再能够为受训者提供所需的必要技能实施个性化医学革命。因此，培训的主要目标个性化心血管医学（TPIPCVM）的计划将装备学员成为 CV基因组学领导者接受分子，细胞，疾病和整个动物建模的训练以及CVD的临床和翻译方法，以便将这些新知识转化为最佳基于证据的个性化简历护理。我们将招募有才华和积极进取的前和动机博士后学员，并为他们提供CV基因组学中最高的口径培训从我们在心脏病学系和UIC的合作伙伴的现有优势中。 3 研究焦点小组：1）心律不齐； 2）缺血性和非缺血性心肌病；和与CVD相关的代谢综合征相互关联，并直接与个性化简历基因组学的中心主题。 TPIPCVM的总体目标是训练下一代简历调查人员创建新知识并实施最佳证据个性化医学。 TPIPCVM导师是非常成功的医师科学家/科学家凭借可靠的研究记录，指导和协作，他们提供了极好的间和多种纪律培训机会。该培训计划的主要优势包括：暴露综合基础科学分子，细胞和整个患者方法的学员，以识别 CVD的基本机制；教师的往绩及其对个性化的简历基因组学；个性化简历医学的专门培训；以及潜力实施科学发现，以对照顾AT的各种和代表性不足的患者人群 UIC医疗中心。 TPIPCVM着手训练2个前博士和2名博士后学生每年。总的来说，该培训计划提供了独特的培训经验，并实现了紧急的需要培训个性化简历医学。

项目成果

期刊论文数量（20）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Nicotinamide restores tissue NAD+ and improves survival in rodent models of cardiac arrest.

DOI：
10.1371/journal.pone.0291598
发表时间：
2023
期刊：
PloS one
影响因子：
3.7
作者：
通讯作者：

Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis.

DOI：
10.1084/jem.20221388
发表时间：
2023-11-06
期刊：
The Journal of experimental medicine
影响因子：
0
作者：
通讯作者：

Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model.

DOI：
10.1172/jci.insight.155640
发表时间：
2022-04-08
期刊：
JCI INSIGHT
影响因子：
8
作者：
Ly, Olivia T.;Chen, Hanna;Brown, Grace E.;Hong, Liang;Wang, Xinge;Han, Yong Duk;Pavel, Mahmud Arif;Sridhar, Arvind;Maienschein-Cline, Mark;Chalazan, Brandon;Ong, Sang-Ging;Abdelhady, Khaled;Massad, Malek;Rizkallah, Lona Ernst;Rehman, Jalees;Khetani, Salman R.;Darbar, Dawood
通讯作者：
Darbar, Dawood

Atrial Fibrillation in Inherited Channelopathies.