The role of emotion dysregulation in PTSD symptomology

情绪失调在 PTSD 症状中的作用

• 批准号: 8783040
• 负责人: Abigail Powers Lott
• 金额: $ 4.99万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8783040
• 关键词: Acoustics; Adult; Affect; African American; Anger; Anxiety Disorders; Attention; Awareness; Behavioral; Biological; Biological Markers; Charge; Complex; Conflict (Psychology); Cues; Data; Development; Diagnostic and Statistical Manual of Mental Disorders; Dimensions; Disease; Emotional; Emotions; Event; Exposure to; Extinction (Psychology); Eye; Face; Failure; Fright; Galvanic Skin Response; General Population; Goals; Individual; Interview; Link; Longevity; Low income; Maintenance; Measurement; Measures; Medical; Mental disorders; Methods; Metric; Minority; Multiple Trauma; National Institute of Mental Health; Pathway interactions; Patient Self-Report; Physiological; Population; Populations at Risk; Post-Traumatic Stress Disorders; Process; Psychological Factors; Psychopathology; Psychophysiology; Reaction Time; Recording of previous events; Reflex action; Regulation; Research; Research Personnel; Risk; Role; Sampling; Stimulus; Stress; Symptoms; Technology; Trauma; affective neuroscience; avoidance behavior; behavior measurement; computerized; design; emotion regulation; emotional experience; experience; high risk; inner city; instrument; negative emotional state; novel; patient population; pediatric trauma; psychologic; public health relevance; showing emotion

DESCRIPTION (provided by applicant): Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder that develops in a subset of people exposed to traumatic events. The rate of lifetime PTSD in low income, inner-city populations where there is significantly increased risk for exposure to multiple traumatic events and childhood trauma is much higher than the general population. Studying PTSD symptomatology in this type of at-risk sample provides a unique opportunity to better understand underlying mechanisms in the development and maintenance of PTSD symptoms. One psychological factor that may determine greater risk in the development of PTSD symptoms is emotion dysregulation. Emotion dysregulation reflects deficits in awareness and acceptance of emotions as well as in regulation strategies to manage intense negative emotional states. Research has already shown that emotion dysregulation can be viewed as a transdiagnostic process that contributes to many types of adult psychopathology, including PTSD. Difficulties with emotion regulation are often found in individuals exposed to traumatic events and evidence suggests that these problems can develop early on and persist into adulthood. Therefore, the role of emotion dysregulation in trauma-related psychopathology may be particularly salient in populations at risk for exposure to multiple traumas across the lifespan. These findings all suggest that emotion dysregulation may be a critical factor in understanding the complex relationship between trauma, PTSD, and other psychopathology. While there is growing evidence to suggest the importance of emotion dysregulation in PTSD symptomology, most research on emotion dysregulation has focused on unidimensional self-report measures and has not established how emotion dysregulation relates to objectively identified biomarkers of PTSD. Furthermore, because of the varied presentation of PTSD symptoms, it is critical that research move beyond a focus on the categorical disorder and instead [evaluate differential effects on the continuous presentation of symptoms across intrusion, avoidance, numbing and hyperarousal symptom clusters. This approach is highly relevant to the NIMH RDoC initiative in that it will include biological in addition to psychologica metrics and examine constructs that cut across DSM defined disorders.] Specifically, the present study will use subjective and behavioral measures of emotion dysregulation and evaluate how these differentially relate to the PTSD symptom clusters as well as behavioral and physiological biomarkers of PTSD in a highly traumatized urban minority population with the goal of understanding pathways between trauma exposure and PTSD symptoms.

描述（由申请人提供）：创伤后应激障碍 (PTSD) 是一种使人衰弱的精神疾病，在暴露于创伤事件的一部分人群中出现。低收入内城区人群的终生 PTSD 发生率，这些人群的风险显着增加 遭受多重创伤事件和童年创伤的比例远高于一般人群。研究此类高危样本的 PTSD 症状学为更好地了解 PTSD 症状发展和维持的潜在机制提供了独特的机会。 可能决定出现 PTSD 症状的更大风险的心理因素之一是情绪失调。情绪失调反映了对情绪的认识和接受以及管理强烈负面情绪状态的调节策略的缺陷。研究已经表明，情绪失调可以被视为一种跨诊断过程，导致多种类型的成人精神病理学，包括创伤后应激障碍 (PTSD)。情绪调节困难经常发生在遭受创伤事件的个体中，有证据表明这些问题可能在早期就出现并持续到成年期。因此，情绪失调在创伤相关精神病理学中的作用可能在一生中面临多次创伤风险的人群中尤为突出。这些发现都表明，情绪失调可能是理解创伤、创伤后应激障碍和其他精神病理学之间复杂关系的关键因素。 虽然越来越多的证据表明情绪失调在 PTSD 症状学中的重要性，但大多数关于情绪失调的研究都集中在单维自我报告测量上，尚未确定情绪失调与客观识别的 PTSD 生物标志物之间的关系。此外，由于 PTSD 症状的表现多种多样，因此研究的重点不应局限于分类障碍，而是[评估侵入、回避、麻木和过度警觉症状群对症状连续表现的差异影响。这种方法与 NIMH RDoC 倡议高度相关，因为它将包括生物学指标和心理学指标，并检查跨越 DSM 定义的疾病的结构。] 具体来说，本研究将使用情绪失调的主观和行为测量，并评估这些测量如何与高度创伤的城市少数民族人群中的 PTSD 症状群以及 PTSD 的行为和生理生物标志物存在差异相关，目的是了解创伤暴露与 PTSD 症状之间的途径。