National Swine Resource and Research Center 1

国家生猪资源研究中心1

• 批准号: 10453315
• 负责人: RANDALL S PRATHER
• 金额: $ 29.15万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10453315
• 关键词: Adoption; Anatomy; Animals; Applied Research; Area; Arteriosclerosis; Biomedical Research; Cardiovascular Diseases; Cells; Characteristics; Communicable Diseases; Communities; Country; Critical Pathways; Cryopreservation; Diabetes Mellitus; Discipline; Disease; Educational Activities; Educational workshop; Embryo; Ensure; Family suidae; Future; Genes; Genetic; Genetic Diseases; Genetic Engineering; Genetic Materials; Germ Cells; Goals; Grant; Health; Human; Individual; Infrastructure; Laboratories; Maintenance; Manuscripts; Medical Device; Medical Research; Methods; Modeling; Modification; Molecular; Monitor; Optics; Organ; Patients; Pharmaceutical Preparations; Physiological; Physiology; Play; Production; Progress Reports; Publishing; Quality Control; Reagent; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Role; Scientist; Serology test; Services; Site; Somatic Cell; Study models; Technology; Testing; Therapeutic; Therapeutic Agents; Tissues; Training Activity; Training and Education; Translational Research; United States; United States National Institutes of Health; Xenograft procedure; animal care; base; biosecurity; clinical practice; drug development; embryo cell; experience; germ free condition; human disease; human model; improved; innovation; investigator training; meetings; novel therapeutic intervention; novel therapeutics; operation; pathogen; pig genome; porcine model; pre-clinical; predictive modeling; prevent; recruit; repository; rho; sperm cell; tool

Abstract (Overall) The overall goal of this application is to continue and expand operation of the National Swine Resource and Research Center (NSRRC). The NSRRC is in its 14th year of operation and it has developed the infrastructure needed to assist swine-based research across multiple disciplines, including xenotransplantation. The NSRRC has developed new models of human disease by genetic engineering, it has recruited models created by others, and it has distributed expertise, cells, tissues, organs and pigs to investigators throughout the United States. Since genetic engineering of pigs requires specialized facilities and expertise, the NSRRC provides invaluable services to the research community by using the latest in gene editing technology to create new genetically-engineered swine models. The NSRRC also provides training and education by interacting with individuals, publishing manuscripts and sponsoring workshops and meetings that promote the use of pigs for studying human diseases. The NSRRC has a state-of-the-art building with high biosecurity to house animals free of specific pathogens. The Specific Aims for the upcoming grant period are as follows: 1. To operate the National Swine Research and Resource Center. Functions of the NSRRC will continue to include: a) importation of existing swine models of human health and disease; b) rederivation of pigs to eliminate specific pathogens, and health monitoring to assure maintenance of a specific pathogen-free status; c) cryopreservation and storage of gametes, embryos, and somatic cells to prevent future loss of valuable models; d) distribution of expertise, reagents, cells, tissues, organs, and pathogen-free pigs; and e) use state of the art technology for the creation of new genetically-engineered pigs needed by the biomedical research community. Rigorous quality control will ensure that only high quality genetics are distributed. The NSRRC will also serve as a site for training and educational activities related to research employing swine models. 2. To perform innovative research that will benefit the NSRRC and the biomedical research community. Applied research projects are aimed at improving: a) the cryopreservation of pig reproductive cells and tissues, b) methods for the production of genetically-engineered pigs, c) state-of-the-art testing methods for swine health surveillance, and d) right-size the pig for greater adoption of pig models.

摘要（总体） 该应用程序的总体目标是继续并扩大国家生猪资源和 研究中心（NSRRC）。 NSRRC 已运行 14 年，并开发了 协助跨学科的猪研究所需的基础设施，包括 异种移植。 NSRRC通过基因工程开发了人类疾病的新模型，它 招募了其他人创建的模型，并分发了专业知识、细胞、组织、器官和猪 美国各地的调查人员。由于猪的基因工程需要专门的设施 和专业知识，NSRRC 通过利用最新的技术为研究界提供宝贵的服务 基因编辑技术创建新的基因工程猪模型。 NSRRC 还规定 通过与个人互动、出版手稿和赞助研讨会来进行培训和教育 以及促进利用猪研究人类疾病的会议。 NSRRC 拥有最先进的 具有高度生物安全性的建筑，可容纳没有特定病原体的动物。具体目标 即将到来的资助期如下： 1. 运营国家养猪研究和资源中心。 NSRRC的职能将继续 包括： a) 进口现有的人类健康和疾病猪模型； b) 将猪重新衍生为 消除特定病原体，并进行健康监测以确保维持无特定病原体 地位; c) 配子、胚胎和体细胞的冷冻保存和储存，以防止未来损失 有价值的模型； d) 专业知识、试剂、细胞、组织、器官和无病原体猪的分配；和 e) 使用最先进的技术来创造生物医学所需的新型基因工程猪 研究社区。严格的质量控制将确保只分发高质量的基因。这 NSRRC 还将作为与猪研究相关的培训和教育活动场所 模型。 2. 开展有利于 NSRRC 和生物医学研究界的创新研究。 应用研究项目旨在改进：a) 猪生殖细胞的冷冻保存和 组织，b) 基因工程猪的生产方法，c) 最先进的检测方法 猪的健康监测，以及 d) 调整猪的大小，以便更多地采用猪模型。