Development of a PROMIS measure for adult dental patients

为成年牙科患者开发 PROMIS 措施

基本信息

批准号：
10458620
负责人：
Mike John
金额：
$ 55.01万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10458620
关键词：
Adult Affect Appearance Area Clinical Complex Complex Analysis Data Data Analyses Data Collection Dental Dental General Practice Dental caries Dentistry Development Dimensions Disease Evaluation Focus Groups Four-dimensional Goals Government Agencies Group Interviews Health Health Professional Healthcare Systems Impairment Individual Individual Differences Information Systems International Intervention Intuition Jaw Length Letters Mastication Measurable Measurement Measures Methodology Methods Mouth Diseases Nature Numerical value Oral Oral Characters Oral health Orofacial Pain Outcome Measure Pain Patient Outcomes Assessments Patient Representative Patient Self-Report Patients Process Property Psychometrics Questionnaires Reporting Research Research Personnel Resources Sampling Severities Solid Source Standardization Time Tooth structure Work advanced system base care seeking cognitive interview dentofacial design experience flexibility health assessment health data health related quality of life improved instrument malignant mouth neoplasm oral condition orofacial patient population prevent psychosocial response systematic review theories tool trait treatment effect

项目摘要

Fourteen years ago, PROMIS, the Patient Reported Outcome Measurement Information System, was created as the most advanced system of patient-reported outcome (PRO) measures. It promises efficient, reliable, and valid assessments of how patients perceive their health; however, no measures specific to oral health are available. This situation impedes solid PRO measurement in dentistry and also prevents PROMIS from capturing health more comprehensively. We propose to develop for adults a set of four oral health instruments using PROMIS methodology, based on the recently determined dimensions of oral health-related quality of life, OHRQoL (Oral Function, Orofacial Pain, Orofacial Appearance, Psychosocial Impact). These dimensions represent the main areas where patients perceive the impact of oral disorders. More than 53 patient-reported oral health instruments for adult patients would merge into a standardized, flexible and precise metric to measure oral health impact across oral conditions and dental settings. A profile of four scores, based on the four dimensions, would form the patient-reported oral health metric and characterize a patient’s standing in the space of patient-reported oral health with four “coordinates” – one for each dimension. The goals of this proposal are (i) to explore how well available instruments cover the spectrum of the four patient-reported oral health dimensions Oral Function, Orofacial Pain, Orofacial Appearance, and Psychosocial Impact, (ii) to develop four preliminary item banks, one for each dimension, (iii) to develop four final item banks, one for each dimension, and (iv) to develop four fixed-length instruments based on the item banks, one for each dimension. Existing OHRQoL and other patient-reported oral health data from 2,115 dental patients will be used in secondary data analyses to explore the severity spectrum of the four patient-reported oral health dimensions and how well available questionnaire items cover this spectrum. Questionnaire items from 53 already identified self-report instruments will be supplemented by a systematic search for new questionnaires/items. All identified items will undergo a mixed-methods approach to be synthesized through focus groups and cognitive interviews with representative patient groups. Our process will follow the PROMIS Qualitative Item Review method to identify, evaluate, and revise items to create four preliminary item banks. Next, in a new sample of 2,000 dental patients covering the entire spectrum of functional, painful, aesthetical, and broader psychosocial problems related to oral disorders, the previously generated four preliminary item banks will be investigated and calibrated using item response theory analyses to derive four final item banks. A fixed-length instrument will be derived from each item bank, and its psychometric properties will be evaluated. This project will introduce PROMIS methodology to an important patient population, adult dental patients. Four scores characterizing Oral Function, Orofacial Pain, Orofacial Appearance, and Psychosocial Impact would become the standard tool for assessing oral conditions and treatment effects from the adult patient’s perspective.

十四年前，患者报告的结果测量信息系统Promis是创建的作为最先进的患者报告结果（PRO）措施的系统。它承诺有效，可靠，并且有效评估患者的健康方式；但是，没有针对口腔健康的措施可用的。这种情况阻碍了牙科中的扎实测量健康更全面。我们建议为成人开发一组四种口腔健康工具 Promis方法基于最近确定的口腔健康相关生活质量的维度 OHRQOL（口腔功能，口腔疼痛，口面外观，社会心理影响）。这些维度代表患者感知口腔障碍影响的主要领域。超过53例患者报告成人患者的口腔健康仪器将合并为标准化，灵活和精确的度量，以测量口腔健康影响在口腔条件和牙科环境之间。根据四个分数的概况维度，将形成患者报告的口腔健康指标，并表征患者在空间中的站立患者报告的口腔健康具有四个“坐标” - 每个维度一个。该提议的目标是（i）探索可用仪器如何涵盖四个患者报告的口腔健康的范围尺寸的口腔功能，口腔疼痛，口面外观和社会心理影响，（ii）发展四个初步项目银行，每个维度一个，（iii）开发四个最终项目库，一个用于每个维度，（iv）基于项目库开发四个固定长度仪器，每个维度一个。现有的OHRQOL和其他2115名牙科患者的患者报告的口腔健康数据将用于次要数据分析以探索四个患者报告的口腔健康维度的严重性谱系可用的问卷项目涵盖了此范围。来自53个已经确定的自我报告的问卷项目仪器将通过系统地搜索新问卷/项目来补充仪器。所有已识别的项目将通过焦点小组和认知访谈，接受一种混合方法的方法具有代表性的患者群体。我们的过程将遵循Promis定性项目审查方法，以识别，评估并拒绝项目创建四个初步项目库。接下来，在2,000名牙科患者的新样本中涵盖功能，痛苦，美学和更广泛的社会心理问题的全部范围口腔障碍，将研究和校准先前生成的四个初步物品库项目响应理论分析以得出四个最终项目库。固定长度的仪器将从每种仪器中得出项目库及其心理测量特性将进行评估。该项目将向重要的患者人群，成年牙科患者引入Promis方法。四个表征口腔功能，口腔疼痛，口面外观和社会心理影响的分数将从成年患者的角度评估口服状况和治疗效果的标准工具。