Saccade Target Selection in Naturalistic Visual Search

自然视觉搜索中的扫视目标选择

• 批准号: 10459317
• 负责人: ROBERT M MCPEEK
• 金额: $ 56.25万
• 依托单位: STATE COLLEGE OF OPTOMETRY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10459317
• 关键词: Address; Anatomy; Architecture; Area; Attention; Attention deficit hyperactivity disorder; Automobile Driving; Basic Science; Behavior; Behavioral; Body Weight Changes; Brain; Cells; Color; Complex; Crowding; Data; Data Analyses; Exhibits; Eye Movements; Goals; Hemispatial Neglect; Human; Image; Impairment; Knowledge; Laboratories; Location; Maps; Mediating; Midbrain structure; Modeling; Monkeys; Movement; Muscimol; Neurologic; Neurons; Occupations; Pattern; Perception; Performance; Physiological; Physiology; Population; Poverty; Primates; Process; Production; Reading; Saccades; Series; Shapes; Signal Transduction; Site; Stimulus; Structure; Syndrome; System; Testing; Visual; Visual Perception; Work; base; cooking; experimental study; fovea centralis; frontal eye fields; insight; interest; neural model; rapid eye movement; relating to nervous system; response; superior colliculus Corpora quadrigemina; theories; visual motor; visual processing; visual search; visual stimulus

Project Summary Understanding how we select targets for saccadic eye movements is a basic research question of far-reaching importance. These rapid eye movements allow the fovea to fixate objects of interest, and we typically make more than 170,000 saccades each day. Saccades are essential for efficient visual perception and action: from reading to cooking to driving, most common behaviors heavily engage the saccadic system, and a dysfunctional mechanism for selecting saccade targets would impair performance in all of these everyday activities. The superior colliculus (SC), a key midbrain structure responsible for controlling saccades, is comprised of two subdivisions: the superficial layers (SCs), which respond predominantly to visual stimuli, and the intermediate layers (SCi), which can show both visual and saccade-related responses. Despite its importance, we still know little about how the SC selects saccade targets in realistic conditions. This study will address this critical gap in our knowledge. A major obstacle to progress in this area has been the complexity of analyzing neural responses under naturalistic conditions, and tackling this problem requires a model that can provide testable predictions of neural responses in naturalistic conditions. We will use a state-of-the-art neural model, MASC (Model of Attention in the Superior Colliculus), which incorporates constraints based on SC anatomy and physiology, and does a superior job of predicting saccade endpoints and scanpaths in a variety of search and free-viewing tasks. In conjunction with neural recordings, we will elucidate how superficial- and intermediate-layer SC neurons differ in their integration of activity related to salience, relevance, inhibitory tagging, and movement selection during multi-saccade visual search. In addition, we will test the contributions of the frontal eye field, a cortical area providing input to the SC, to these search-related signals in the SC.

项目摘要 了解我们如何选择saccadic眼动目标的目标是深远的基础研究问题 重要性。这些快速的眼睛运动允许Fovea固定感兴趣的对象，我们通常会使 每天超过170,000个扫视。扫视对于有效的视觉感知和动作至关重要： 读取烹饪到驾驶，最常见的行为与saccadic系统相关，并且 选择扫视目标的功能失调的机制将损害所有这些每天的性能 活动。高级丘（SC）是负责控制扫视的关键中脑结构，是 由两个细分组成：浅层层（SC），主要对视觉刺激做出反应，并且 中间层（SCI），可以显示视觉和扫视相关的响应。尽管有它 重要的是，我们仍然对SC在现实条件下如何选择扫视目标知之甚少。这项研究会 在我们的知识上解决这个关键差距。该领域进步的主要障碍是复杂的 在自然条件下分析神经反应，解决此问题需要一个模型 在自然主义条件下提供可检验的神经反应的预测。我们将使用最先进的神经 模型，MASC（上丘中的注意力模型），该模型基于SC结合了约束 解剖学和生理学，并且在预测各种扫视终点和扫描路径方面做得出色 搜索和免费查看任务。结合神经记录，我们将阐明如何表面和 中级SC神经元在与显着性，相关性，抑制性相关的活动的整合中有所不同 标记和在多节奏视觉搜索过程中选择的运动选择。此外，我们将测试贡献 在额叶区域（向SC提供输入的皮质区域）中，这些与SC中的这些与搜索相关的信号。