Cortical and subcortical control of saccades

眼跳的皮质和皮质下控制

• 批准号: 8631823
• 负责人: ROBERT M MCPEEK
• 金额: $ 37.43万
• 依托单位: STATE COLLEGE OF OPTOMETRY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8631823
• 关键词: Affect; Architecture; Area; Attention deficit hyperactivity disorder; Behavior; Biological Models; Brain; Brain Stem; Cognitive; Color; Communication; Complex; Conflict (Psychology); Crowding; Cues; Data; Decision Making; Development; Diagnosis; Disease; Etiology; Eye Movements; Feedback; Generations; Goals; Impaired cognition; Individual; Lead; Link; Location; Mediating; Methods; Modeling; Movement; Nature; Neurons; Output; Pathway interactions; Performance; Phase; Play; Prefrontal Cortex; Process; Production; Rehabilitation therapy; Role; Saccades; Signal Transduction; Site; Staging; Stimulus; Techniques; Testing; Time; Vision; Visual; Visual Fields; Work; abstracting; base; frontal eye fields; frontal lobe; improved; insight; neglect; neuromechanism; prevent; public health relevance; research study; superior colliculus Corpora quadrigemina

Project Summary Rapid and accurate saccadic eye movements are crucial for vision. Since real-world scenes are often crowded with many objects, a fundamental requirement for saccades is the serial selection of single targets from a field of multiple potential targets. Saccade target selection is subserved by a network of cortical and subcortical brain areas, but we still have little idea of how activity across these areas is coordinated. This project investigates the interactions among the superior colliculus (SC), the frontal eye field (FEF), and the dorsolateral prefrontal cortex (dlPFC). The SC is regarded as the gateway for eye-movement commands from cortex to reach the brainstem, but perturbations in SC activity do not just affect the execution of saccades; they also influence the selection of eye-movement targets. This raises a key question: Does the SC simply act as a final selection stage before transmitting saccade commands downstream, or does SC activity influence saccadic decision-making in cortex? To answer this, we will simultaneously record isolated neurons and local field potentials from SC and FEF, and apply advanced analysis techniques to reveal the interactions and likely flow of information between these two areas. Next, we will perturb activity in the SC by temporarily inactivating a portion of it, and will determine whether and how selection-related activity in FEF is altered. We will also investigate how frontal cortex influences selection in the SC. Specifically, frontal area dlPFC is thought to be particularly important for selection based on abstract rules or internal goals. We will test this idea and investigate dlPFC's influence on the SC by analyzing simultaneously-recorded activity in the two areas during performance of rule-governed and salience-based selection tasks. Finally, to test for a causal link with dlPFC, we will record behavior and SC activity while dlPFC is temporarily inactivated. The results will not only provide new information about the functional architecture of saccadic decision-making; they will also lead toward a better understanding of how cortical and subcortical brain areas interact in performance of a cognitive task.

项目摘要 快速，准确的眼球运动对于视力至关重要。由于实际场景通常是 挤满了许多物体，扫视的基本要求是单个目标的序列选择 来自多个潜在目标的领域。扫视目标选择由皮质和 皮质下的大脑区域，但我们仍然对这些区域的活动如何协调一无所知。这 项目调查了上柯利库斯（SC），额眼场（FEF）和 背外侧前额叶皮层（DLPFC）。 SC被视为眼动命令的门户 从皮质到达到脑干，但是SC活动的扰动不仅会影响执行 扫视；它们还会影响眼动目标的选择。这提出了一个关键问题：是否 SC只是在传输扫视命令下游或进行SC之前，简单地充当最终选择阶段 活动会影响皮质中的Saccadic决策？为了回答这个问题，我们将同时记录孤立的 SC和FEF的神经元和局部现场潜力，并应用高级分析技术来揭示 这两个领域之间的相互作用和信息流。接下来，我们将在SC中扰动活动 通过暂时灭活其中的一部分，并将确定是否以及如何与选择相关的活动 FEF已更改。我们还将研究额叶皮质如何影响SC中的选择。具体而言，额叶 认为区域DLPFC对于基于抽象规则或内部目标的选择特别重要。我们 将测试这个想法，并通过分析同时录制的活动来研究DLPFC对SC的影响 在执行规则和基于显着的选择任务的两个领域中。最后，测试 与DLPFC的因果链接，我们将记录行为和SC活动，而DLPFC暂时失活。这 结果不仅将提供有关SACCADIC决策功能架构的新信息； 他们还将更好地理解皮质和皮层下大脑区域的相互作用 认知任务的表现。