Collaborative Research and Action: Empowering an Exposed Community

协作研究和行动：为暴露的社区赋权

• 批准号: 10329029
• 负责人: MICHELE MARCUS
• 金额: $ 55.5万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10329029
• 关键词: Address; Advisory Committees; Affect; Age at Menarche; Agriculture; Animals; Arthralgia; Arthritis; Attention; Autoimmune; Awareness; Body Burden; Breast Feeding; Chemicals; Child; Clinical Trials; Communities; DNA; DNA Methylation; Data; Disasters; Double-Blind Method; Double-blind trial; Educational Materials; Endocrine Disruptors; Environment; Environmental Exposure; Environmental Health; Epigenetic Process; Estrogens; Event; Exposure to; Family; Family Study; Family health status; Fathers; Female; Flame Retardants; Food Chain; Frustration; Funding; Future Generations; Gene Expression; Generations; Genitourinary system; Goals; Growth and Development function; Health; Health Fairs; Health Personnel; Heritability; Human; Human body; Individual; Inherited; Leadership; Liver; Livestock; Malignant Neoplasms; Maternal Exposure; Menarche; Methods; Michigan; Migraine; Mothers; Nerve Degeneration; Neurodegenerative Disorders; Neurologic; Nutritional; Outcome; Pain Disorder; Pancreas; Parents; Participant; Patient Recruitments; Pattern; Pilot Projects; Poison; Policy Maker; Polybrominated Biphenyls; Public Health; Questionnaires; Randomized; Recording of previous events; Registries; Replacement Arthroplasty; Reproduction; Reproductive system; Research; Research Personnel; Risk; Rivers; Sampling; Scientist; Serum; Ships; Somatic Cell; Spontaneous abortion; Superfund; Time; Universities; Uterus; Woman; Work; adverse outcome; cohort; college; dietary; dietary supplements; empowered; endocrine disruptor exposure; epigenome; experience; immune function; interest; lipophilicity; male; meetings; member; men; methylation pattern; offspring; parent grant; persistent organic pollutants; programs; recruit; reproductive outcome; social media; sperm cell; tool

Project Summary/Abstract: The Michigan PBB Registry was established in order to study the health of thousands of people exposed to brominated flame retardants as a result of the largest agricultural disaster in US history. Previous research by this team has shown significant health effects associated with exposure to polybrominated biphenyls (PBB) including earlier menarche, increased risk of miscarriages and lower estrogen levels among women, and more urogenital problems among men. Over the past few years, Emory researchers have conducted over two dozen community meetings throughout Michigan, collaborated with community partners, shared research findings with the community, responded to community needs, and sought community input for future research plans. This proposed study, collaboratively developed by scientists, community partners, and public health officials, addresses several major concerns expressed by the PBB community. Specifically, affected individuals have expressed interest in a possible treatment to remove PBBs from their bodies, concern about heritable effects from PBB on their children and grandchildren, continuing health concerns beyond those related to reproduction, and frustration that local health-care providers seem unaware of the statewide PBB exposure and/or its possible health effects. To address these concerns, the proposed study has four specific aims. The first is to evaluate the utility of a nutritional aid as a potential means of accelerating the elimination of PBB by conducting a randomized double-blind clinical trial. The second aim will explore the heritability of changes in the epigenome associated with PBB exposure by studying families across three generations. The epigenome of parents, their children, and their grandchildren will be examined to determine if epigenetic patterns associated with direct exposure to PBB of parents are apparent in the children and grandchildren. Aim three will address community concerns regarding additional health effects beyond reproductive outcomes. Participants will complete health questionnaires and provide serum samples for analysis to determine if PBB exposure is associated with neurodegenerative diseases, joint pain/disorder, cancer, immune function and liver/pancreatic problems. If any of the self-identified adverse outcomes are associated with PBB exposure, additional funding will be sought to further explore these associations. Finally, the public health action plan will seek to raise environmental health awareness in Michigan. Educational programs will be developed for healthcare providers, policy-makers, and citizens to increase local capacity to address exposure concerns.

项目摘要/摘要： 建立了密歇根州PBB注册表，以研究成千上万的人的健康 由于美国历史上最大的农业灾难而导致的溴化阻燃剂。先前的研究 该团队显示出与暴露于多溴双苯基（PBB）有关的重大健康影响 包括早期的初潮，流产的风险增加，女性中雌激素水平降低，更多 男性泌尿生殖器问题。在过去的几年中，埃默里研究人员进行了二十多次 整个密歇根州的社区会议，与社区合作伙伴合作，分享了研究结果 有了社区，对社区需求做出了响应，并寻求社区意见以制定未来的研究计划。 这项提出的研究是由科学家，社区伙伴和公共卫生官员共同开发的， 解决了PBB社区表达的几个主要问题。具体来说，受影响的人有 对可能的治疗方法表达了兴趣，以使PBB从身体中删除PBB，对可遗传效果的担忧 从PBB对孩子和孙子们的持续健康问题，超出了与之相关的健康问题 繁殖和沮丧，当地医疗保健提供者似乎不知道全州PBB的暴露 和/或它可能的健康影响。为了解决这些问题，拟议的研究具有四个具体目标。这 首先是评估营养援助的实用性，以此作为加速消除PBB的潜在手段 进行随机双盲临床试验。第二个目标将探索变化的遗传力 通过研究三代家庭的家庭，与PBB暴露有关的表观基因组。表观基因组 父母，他们的孩子和他们的孙子将进行检查，以确定表观遗传模式是否 在孩子和孙子孙女中，与直接接触父母的PBB有关。瞄准三 将解决社区对生殖结果以外其他健康影响的担忧。 参与者将填写健康问卷，并提供血清样本进行分析，以确定是否PBB 暴露与神经退行性疾病，关节疼痛/疾病，癌症，免疫功能和 肝脏/胰腺问题。如果任何自我识别的不良结果与PBB暴露有关， 将寻求额外的资金来进一步探索这些关联。最后，公共卫生行动计划将 寻求提高密歇根州的环境健康意识。将为教育计划开发 医疗保健提供者，政策制定者和公民增加当地解决暴露问题的能力。