MI PBB Cohort 30 years later: Endocrine Disruption?

MI PBB 队列 30 年后：内分泌干扰？

基本信息

批准号：
6561514
负责人：
MICHELE MARCUS
金额：
$ 46.16万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-30 至 2007-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The investigators propose a targeted investigation of endocrine-related outcomes in individuals in the Michigan PBB Registry and their offspring to follow up intriguing findings of a study recently completed by this team. In 1973, inadvertent substitution of a livestock feed supplement with fire retardant led to widespread contamination of meat and dairy products in Michigan with polybrominated biphenyls (PBBs), a class of chemicals toxicologically similar to PCBs, PBDE, DDE and other halogenated organics suspected to disrupt endocrine function. Over 4000 individuals with high likelihood of exposure were subsequently enrolled into the Michigan PBB Registry, and serum samples were analyzed for PBB. The proposers recently completed a twenty-year follow up survey of women in the registry regarding occurrence of endocrine-related outcomes, and the current application will pursue key findings of this survey as follows. The observation of an association of perinatal PBB exposure with reduced age at menarche in the daughters of registry participants will be followed up in two ways: 1) an expanded assessment of ovarian function in a subgroup of the daughters, using menstrual diaries and hormonal assays of daily urine samples (50 high exposure, 50 low exposure), and 2) an investigation of pubertal development in the sons of women in the registry to assess whether analogous impacts on pubertal development are observed in the boys, using a questionnaire assessment of Tanner stages and other pubertal landmarks in sons less than 18 years of age (n=204). The suggestion of an excessive spontaneous abortion rate among the exposed daughters of reproductive age will be followed up by: 1) updating the reproductive histories of the daughters over age 18 (n=214), and 2) by determining reproductive success in the sons over 18 years of age (n=218). Finally, the finding of altered menstrual cycle characteristics among the women in the registry will, be pursued by performing a menstrual diary and urinary hormone study in the adult women (50 high exposure, 50 low exposure) similar to that proposed for the daughters. Each of the proposed investigations allows targeted, efficient follow up of the important findings observed in the previous study, and will provide further insight into possible impacts of this class of chemicals on pubertal development, reproductive health and ovarian function.

描述（由申请人提供）：调查人员提出针对密歇根州PBB注册中心的内分泌相关结果的有针对性调查，以跟进该团队最近完成的一项研究的有趣发现。 1973年，无意取代牲畜饲料补充剂，用阻燃剂替代了密歇根州的肉类和乳制品的广泛污染，该肉类和乳制品在密歇根州用多溴双苯基（PBBS）（PBBS），这类化学物质毒性类似于类似于PCBS，PBDE，DDE，DDE，DDE，DDE和其他怀疑的有机物的内部分泌功能。随后将超过4000名暴露可能性高的人纳入密歇根州PBB注册表，并分析了PBB的血清样品。提议者最近对登记处的妇女进行了二十年的随访调查，涉及与内分泌相关结果的发生，目前的申请将遵循此调查的关键发现。将通过两种方式进行注册参与者的围产期PBB暴露与初潮年龄较低的年龄的关联的观察：1）使用月经习惯和荷尔蒙的尿液样本（50次高曝光率）的卵巢群体中对卵巢功能的扩展评估，并进行了50次高暴露于次数的狂暴，并提出了50个次数的次数。注册表评估男孩中是否观察到对青春期发展的类似影响，使用问卷调查评估坦纳阶段和其他不到18岁的儿子（n = 204）。在裸露的生殖年龄裸露女儿中，过度自发流产的率的建议将随后：1）通过确定18岁以上的儿子的生殖成功（n = 218岁），更新18岁以上（n = 214）的女儿的生殖历史。最后，通过在成年妇女（50个高暴露，50个低暴露暴露）中进行月经日记和尿激素研究来追求注册表中女性的月经周期特征改变的发现，类似于女儿。每个提出的研究都允许对先前研究中观察到的重要发现有针对性，有效的随访，并将进一步了解这类化学物质对青春期发展，生殖健康和卵巢功能的可能影响。