Boston Latino Aging Study (BLAST): Understanding Alzheimer's risk and biomarkers in older Latinos

波士顿拉丁裔老龄化研究 (BLAST)：了解老年拉丁裔的阿尔茨海默病风险和生物标志物

• 批准号: 10322722
• 负责人: Yakeel T. Quiroz
• 金额: $ 83.96万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10322722
• 关键词: Address; Administrative Supplement; Aging; Alzheimer associated neurodegeneration; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease pathology; Alzheimer' s disease risk; Amyloid; Amyloid beta-Protein; Biological Markers; Boston; Brain; Brain Pathology; Cardiovascular Diseases; Chronic stress; Cognition; Cognitive; Communities; Dementia; Development; Diabetes Mellitus; Disease; Early Diagnosis; Elderly; Enrollment; Exhibits; Fibrinogen; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; High Prevalence; Hypertension; Image; Impaired cognition; Individual; Intervention; Knowledge; Latino; Latino Population; Link; Massachusetts; Measures; Memory; Moods; Nerve Degeneration; Onset of illness; Participant; Pathology; Patient Self-Report; Physical activity; Population; Positron-Emission Tomography; Prevalence; Prevention; Registries; Research; Rest; Risk; Risk Factors; Risk Marker; Sleep; Sleep disturbances; Time; Visit; Work; affective disturbance; aging brain; amyloid pathology; base; cardiovascular risk factor; cognitive performance; cohort; dementia risk; design; follow-up; good diet; improved; in vivo; life-long learning; middle age; modifiable risk; molecular marker; network dysfunction; neuroimaging; non-demented; normal aging; novel; pre-clinical; preventive intervention; recruit; tau Proteins

Latinos are the fastest growing subpopulation of older adults in the U.S.A. and have a greater prevalence of Alzheimer’s disease (AD) than non-Latino whites (1). Despite this, our knowledge of normal aging, cognitive decline, and AD-related neurodegeneration in Latinos is sparse. A growing body of evidence supports a link between AD onset and several modifiable factors, some of which convey risk (e.g., mid-life hypertension, sleep and mood distrurbance). Other factors are considered protective, such as engaging in regular physical activity, managing cardiovascular risk factors (i.e., diabetes, obesityand hypertension), maintaining a healthy diet, and engaging in lifelong learning (2). It is also known that some of these modifiable risk factors have a higher prevalence in Latinos, compared to non-Latinos (3). Nonetheless, how these factors independently or interactively make older Latinos more vulnerable to accumulation of AD pathology, cognitive decline, and dementia remains unclear. Thus, investigating the impact of different AD risk factors on cognition, brain function, and AD molecular markers of pathology in older Latinos is pivotal to improving prevention, early detection, and development of novel treatments and interventions for this critically underserved and understudied population. To promote recruitment and participation of Latinos in biomarker and aging research, we initiated a registry of older community-dwelling Latinos living in Massachusetts (known as the Boston Latino Aging Registry). Furthermore, with the support of an administrative supplement in 2019 we began to include more Latino participants in the ongoing NIA-funded Harvard Aging Brain Study, which is now known as Latino HABS. We propose to build upon these previous recruitment efforts to study aging and preclinical AD in non-demented older Latinos and non-Latino White individuals. All participants will undergo a comprehensive assessment of cognition, amyloid and tau PET scanning, as well as structural and resting fMRI. They will also complete self- report measures of modifiable dementia risk factors (e.g. cardiovascular disease, sleep, mood), all of which will be used to create an overall dementia risk score. Comparisons between Latinos and non-Latinos will be made in all aims with the goal of using the findings to validate and inform biomarker findings in older Latinos. Our ultimate goal is to build a cohort of older Latinos that we can be followed up overtime. For the current R01 grant, we propose to enroll a total of 200 older community dwelling individuals (60-80 years; 150 Latinos and 50 non-Latinos) and compare them to 200 already enrolled in HABS (60-80 years; 150 non-Latinos and 50 Latinos) to 1) investigate modifiable dementia risk factors and cognition in older Latinos and non-Latinos; 2) examine modifiable dementia risk factors and memory network dysfunction in older Latinos and non-Latinos; and 3) examine the associations between modifiable dementia risk factors and markers of brain pathology in older Latinos and non-Latinos.

拉丁美洲人是美国老年人增长最快的亚人群，并且患病率更高 阿尔茨海默氏病（AD），而不是非拉丁裔白人（1）。尽管如此，我们对正常衰老，认知的了解 拉丁美洲人的下降，与广告相关的神经变性很少。越来越多的证据支持链接 在AD发作和几个可修改因素之间，其中一些传达了风险（例如，中期高血压，睡眠 和情绪干扰）。其他因素被认为受到保护，例如进行常规体育锻炼， 管理心血管危险因素（即糖尿病，肥胖和高血压），保持健康的饮食和 从事终身学习（2）。众所周知，其中一些可修改的危险因素具有更高的 与非拉丁裔相比，拉丁裔的患病率（3）。但是，这些因素如何独立或 互动使较旧的拉丁裔更容易受到广告病理的积累，认知能力下降和 痴呆症仍然不清楚。这是调查不同AD风险因素对认知的影响，大脑 较老的拉丁裔病理学的功能和AD分子标记对于改善预防是关键的， 早期检测和开发新的治疗方法和干预措施 并了解人口。 为了促进拉丁美洲人在生物标志物和衰老研究中的招聘和参与，我们启动了注册表 居住在马萨诸塞州的老年社区拉丁美洲裔（称为波士顿拉丁裔老化注册表）的著作。 此外，在2019年的行政补品的支持下，我们开始包括更多拉丁裔 正在进行的NIA资助的哈佛大学脑研究的参与者，该研究现在称为拉丁裔HAB。我们 提议以这些先前的招聘工作为基础，以研究衰老和临床前广告 年长的拉丁裔和非拉丁裔白人个体。所有参与者将对 认知，淀粉样蛋白和tau pet扫描，以及结构和静止的fMRI。他们还将完成自我 报告可改变的痴呆危险因素（例如心血管疾病，睡眠，情绪）的措施，所有这些都将 用于创建整体痴呆症风险评分。将进行拉丁裔和非拉丁裔的比较 总体而言，目的是使用发现来验证和告知较旧拉丁美洲人的生物标志物发现。 我们的最终目标是建立一群较旧的拉丁美洲人，我们可以加班。对于电流 R01赠款，我们建议总共注册200名年长的社区住宅（60 - 80年； 150个拉丁美洲人 和50个非latinos），并将其与已经参加了HAB的200个（60 - 80年； 150个非拉丁诺斯和50个） 拉丁裔）至1）研究可改变的痴呆症危险因素和较旧的拉丁裔和非拉丁裔的认知； 2） 检查较旧的拉丁裔和非拉丁裔的可修改痴呆症风险因素和记忆网络功能障碍； 3）检查可修改的痴呆危险因素与脑病理标记之间的关联 较旧的拉丁裔和非拉丁裔。