Moving Forward: A weight loss program for African-American breast cancer survivors

前进：非裔美国乳腺癌幸存者的减肥计划

• 批准号: 8844169
• 负责人: Ben Steven Gerber
• 金额: $ 8.73万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8844169
• 关键词: Address; African American; Age; American; Behavioral; Biological; Biological Markers; Blood Pressure; Body Weight; Body Weight decreased; C-Peptide; Cancer Survivor; Chicago; Cholesterol; Cognitive; Collaborations; Communities; Consumption; Data; Development; Diabetes Mellitus; Diagnosis; Diagnostic Neoplasm Staging; Diet; Dietary Fats; Dietary Fiber; Eating; Estradiol; Estrone; European; Exercise; Exhibits; Fatigue; Fatty acid glycerol esters; Fiber; Food Labeling; Health; Heart Rate; Histology; Hormone Receptor; Hypertension; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Interdisciplinary Study; Intervention; Intervention Studies; Leptin; Life; Life Style; Maintenance; Malignant Neoplasms; Menopausal Status; Monitor; Morbidity - disease rate; Obesity; Outcome; Overweight; Pattern; Physical activity; Psychosocial Factor; Publishing; Quality of life; Randomized; Reading; Recurrence; Reporting; Research Personnel; Resources; Route; SHBG gene; Stage at Diagnosis; Staging; Stimulus; Survival Rate; Testosterone; Tumor stage; Vegetables; Waist-Hip Ratio; Walking; Woman; Work; base; cancer recurrence; efficacy testing; experience; fasting glucose; fitness; fruits and vegetables; innovation; malignant breast neoplasm; member; mortality; post intervention; programs; psychosocial; sedentary; tool; tumor progression; weight loss intervention

DESCRIPTION (provided by applicant): Breast cancer (BC) survival rates are significantly lower for African-American (AA) women compared to European American (EA) women even after controlling for age, SES, tumor stage at diagnosis, hormone receptor status, histology, and menopausal status. This disparity is particularly evident in Chicago where mortality rates for AA women exceed those for EA women by 116 percent. Not only are AA women with BC more likely than EA women to die from their cancer, they are also more likely to die from comorbid conditions including diabetes and hypertension. Poor diet, lack of physical activity, and obesity contribute to breast cancer progression and the development and exacerbation of many comorbid conditions. Efforts to reduce the high mortality rates observed in AA women with breast cancer are critically needed. Addressing poor diet, lack of physical activity, and high rates of obesity may provide the best near-term opportunity to decrease breast cancer and all-cause mortality among AA BC survivors. Although several studies have examined weight loss interventions among EA BC survivors, no interventions developed specifically for AA BC survivors have been examined. Moving Forward is a six-month cognitive-behavioral community-based weight loss intervention that was developed in collaboration with AA BC survivors. This application proposes a randomized intervention study to examine the effects of Moving Forward, compared to a six-month cognitive-behavioral community-based weight loss intervention that was developed in collaboration with AA BC survivors, on BMI and behavioral, biological, and psychosocial outcomes in 240 obese AA women diagnosed with Stage I, II, or III breast cancer. We have partnered with the Chicago Park District (CPD) to implement the study within six predominantly AA Chicago communities. In addition to having an experienced, interdisciplinary study team, this project has several other strengths including innovation in its focus on weight loss in AA BC survivors; the potential for having a positive impact on morbidity and mortality related to breast cancer and comorbid conditions among AA BC survivors; and the potential for sustainability within CPD community programs.

描述（由申请人提供）：即使在控制了年龄、SES、诊断时的肿瘤分期、激素受体状态、组织学和绝经状态。这种差异在芝加哥尤为明显，其中 AA 女性的死亡率比 EA 女性高 116%。患有 BC 的 AA 女性不仅比 EA 女性更有可能死于癌症，而且也更有可能死于糖尿病和高血压等合并症。不良饮食、缺乏体力活动和肥胖会导致乳腺癌进展以及许多合并症的发生和恶化。迫切需要努力降低 AA 女性乳腺癌患者的高死亡率。解决不良饮食、缺乏体力活动和高肥胖率可能为降低 AA BC 幸存者的乳腺癌和全因死亡率提供近期最佳机会。尽管有几项研究检验了 EA BC 幸存者的减肥干预措施，但尚未检验专门为 AA BC 幸存者开发的干预措施。 Moving Forward 是一项为期六个月的基于社区的认知行为减肥干预措施，是与 AA BC 幸存者合作开发的。本申请提出了一项随机干预研究，以检验“前进”的效果，与与 AA BC 幸存者合作开发的为期六个月的基于社区的认知行为减肥干预措施相比，对 BMI 以及行为、生物和心理社会结果的影响240 名被诊断患有 I、II 或 III 期乳腺癌的肥胖 AA 女性。我们与芝加哥公园区 (CPD) 合作，在六个以 AA 为主的芝加哥社区内实施这项研究。除了拥有经验丰富的跨学科研究团队外，该项目还有其他几个优势，包括在 AA BC 幸存者减肥方面的创新；对 AA BC 幸存者中与乳腺癌和合并症相关的发病率和死亡率产生积极影响的潜力；以及 CPD 社区计划的可持续性潜力。