Analytical Core

分析核心

• 批准号: 9015041
• 负责人: CYRUS P ZABETIAN
• 金额: $ 40.33万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9015041
• 关键词: Abbreviations; Alzheimer' s Disease; Autopsy; Biological Assay; Biological Markers; Blood; Brain; Caring; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Clinical; Cognitive; Common Data Element; Communities; Data; Data Analyses; Databases; Dementia; Deposition; Diagnostic; Family member; Foundations; Foxes; Funding; Future; Genetic; Genetic Markers; Genomics; Genotype; Goals; Health Sciences; Impaired cognition; Knowledge; Laboratories; Link; Molecular; National Institute of Neurological Disorders and Stroke; Oregon; Pacific Northwest; Parkinson Disease; Parkinsonian Disorders; Participant; Physicians; Reporting; Research; Research Design; Research Personnel; Research Priority; Resources; Spinal Puncture; Statistical Study; Tissue Sample; Tocopherols; Universities; Washington; age group; base; data management; data sharing; deprenyl; genetic analysis; improved; neuroimaging; neuropathology; outreach; programs; progression marker; repository; synuclein; tau Proteins; tool; volunteer

ANALYTICAL CORE: ABSTRACT The goal of the Analytical Core is to support the efforts of PANUC to understand and treat cognitive impairment in Parkinson's disease (PD). The Analytical Core will continue providing laboratory-based and data analyses in support of all three PANUC projects and the Clinical Core, as well as to linked PD Biomarker Program project (U01 NS082137, PI: Dr. Zhang, also Analytical Core Co-Investigator). We will accomplish our goal of providing both types of analytical support through the following Specific Aims: Specific Aim 1. LABORATORY: Genetic analysis for all three projects and the Clinical Core. CSF biomarkers analysis: Provide management of biofluids from the Clinical Core and analysis of well-established biomarkers for PD and Alzheimer's disease for Clinical Core, Project 2 and the linked U01. Neuropathology analysis: Provide expert analysis of tissue samples from Clinical Core and Project 1. Specific Aim 2. DATA MANAGEMENT and STATISTICAL ANALYSIS: Provide expert data management and statistical support for the Clinical Core and all three Projects and affiliated efforts. This Core serves multiple research priorities set by the NINDS Parkinson's Disease 2014: Advancing Research, Improving Lives.

分析核心：摘要 分析核心的目标是支持 PANUC 理解和治疗认知障碍的努力 帕金森病 (PD)。分析核心将继续提供基于实验室的数据分析 支持所有三个 PANUC 项目和临床核心，以及相关的 PD 生物标志物项目 项目（U01 NS082137，PI：张博士，也是分析核心联合研究员）。我们将实现我们的目标 通过以下具体目标提供两种类型的分析支持： 具体目标 1. 实验室： 所有三个项目和临床核心的遗传分析。 CSF 生物标志物分析：提供管理 来自临床核心的生物流体以及对 PD 和阿尔茨海默病的成熟生物标志物的分析 对于临床核心、项目 2 和链接的 U01。神经病理学分析：提供组织的专家分析 来自临床核心和项目的样本 1. 具体目标 2. 数据管理和统计 分析：为临床核心和所有三个提供专家数据管理和统计支持 项目和附属工作。该核心服务于 NINDS 帕金森氏症制定的多项研究重点 2014 年疾病：推进​​研究，改善生活。