Epidemiology and Genetics of Susceptibility to COVID-19 Infection

COVID-19 感染易感性的流行病学和遗传学

• 批准号: 10702965
• 负责人: Sharon A. Savage
• 金额: $ 59.12万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10702965
• 关键词: 2019-nCoV; Acute; Acute respiratory infection; Authorization documentation; Biological Markers; COVID-19; COVID-19 impact; COVID-19 monitoring; COVID-19 pandemic; COVID-19 risk; Cessation of life; China; Clinical; Communicable Diseases; Communities; Coronavirus; Data; Death Rate; Deposition; Descriptive Epidemiology; Disease; Division of Cancer Epidemiology and Genetics; Epidemiology; Genetic Predisposition to Disease; Individual; Infection; Life; Malignant Neoplasms; Multiple Organ Failure; Outcome; Pneumonia; Population; Prevention Measures; Public Health; Research Personnel; Respiratory Failure; Risk; SARS-CoV-2 infection; Scientist; Symptoms; Syndrome; Testing; United States; United States National Institutes of Health; comorbidity; data sharing; effective therapy; epidemiology study; genetic variant; multidisciplinary; pandemic disease; respiratory; severe COVID-19

Infection by the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in the infectious disease syndrome known as coronavirus disease 2019 (COVID-19). SARS-CoV-2 was originally described in late 2019 in Wuhan, China and has since spread throughout the world causing the 2019-2020 COVID-19 pandemic. While many individuals with SARS-CoV-2 infection may have mild or few symptoms, others have life threatening illness including severe pneumonia and multi-organ failure. As of May 12, 2020, there have been 1,342,594 cases and 80,820 deaths in the United States due to COVID-19 (https://cdc.gov). This approximately 6% death rate and lack of effective treatment or prevention measures illustrates the urgent need to understand factors associated with risk of severe COVID-19 disease. Irrespective of the actual rate of severe disease and death, it is clear that there will be enormous numbers of severe cases worldwide and management strategies are desperately needed.This is a multi-disciplinary collaborative project with the primary aim of understanding why some individuals with COVID-19 infection have mild clinical symptoms, while others have very severe disease resulting in respiratory failure, multi-organ failure, and death. The multiple aims of this project utilize the wide-ranging expertise of scientists in the Division of Cancer Epidemiology and Genetics, NCI1) Identify common and rare germline genetic variants associated with risk of COVID-19 infection and outcomes; 2) Identify other biomarkers associated with risk of COVID-19 infection and outcomes; 3) Characterize the contribution of co-morbid conditions, including current or prior cancer to COVID-19 infection and outcomes; 4) Conduct descriptive epidemiology studies aimed at understanding the population-level consequences of COVID-19 on public health and disease; 5) Identify optimal testing strategies to detect and monitor COVID-19 in populations; and 6) Deposit and share data as fast as possible to allow community analyses by bona-fide researchers who seek permission to analyze the data according to NIH data sharing precepts.

急性呼吸道综合征冠状病毒2（SARS-COV-2）感染导致感染性疾病综合征2019年冠状病毒病（COVID-19）。 SARS-COV-2最初是在2019年底在中国武汉描述的，此后一直在全球范围内蔓延，导致2019 - 2020年Covid-19-19大流行。尽管许多患有SARS-COV-2感染的人可能患有轻度或很少的症状，但其他人则患有危害生命的疾病，包括严重的肺炎和多器官衰竭。截至2020年5月12日，由于19日，美国有1,342,594例和80,820例死亡（https://cdc.gov）。大约6％的死亡率和缺乏有效的治疗或预防措施表明，迫切需要了解与严重Covid-19的风险相关的因素。不论严重疾病和死亡的实际率如何，很明显，全世界都需要大量的严重病例和管理策略。这是一个多学科的合作项目，其主要目的是理解为什么有些Covid-19患者有些患有COVID-19的人有轻度的临床症状，而另一些人则在呼吸衰竭中导致非常严重的疾病，导致呼吸衰竭衰竭，而多型骨骼失败，以及多孔，而多孔。该项目的多个目标利用了科学家在癌症流行病学和遗传学划分方面的广泛专业知识，NCI1）确定了与Covid-19感染和结果风险相关的常见和稀有种系遗传变异； 2）确定与Covid-19感染和结局风险相关的其他生物标志物； 3）表征合并症条件的贡献，包括当前或先前的癌症对COVID-19的感染和结局； 4）进行描述性流行病学研究旨在了解Covid-19对公共卫生和疾病的人口水平的后果； 5）确定最佳测试策略以检测和监视人群中的共同测试； 6）尽可能快地存入和共享数据，以允许寻求根据NIH数据共享戒律来分析数据的善意研究人员进行社区分析。