Software for improved accuracy and rapid tracking of kinematics from dynamic Xray

用于提高动态 X 射线运动学精度和快速跟踪的软件

基本信息

批准号：
8592857
负责人：
W. Scott Selbie
金额：
$ 14.91万
依托单位：
C-MOTION, INC.
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-15 至 2014-01-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8592857
关键词：
Adult Affect Algorithms Angiography Architecture Arthritis Biomechanics Cardiovascular Diseases Cartilage Clinical Clinical Research Computer software Data Data Set Development Devices Diagnosis Diagnostic Imaging Diagnostic radiologic examination Disease Environment Future Goals Health Image Individual Intervention Joints Kinetics Knowledge Laboratories Left Libraries Ligaments Magnetic Resonance Imaging Mechanics Medical Metric Morphologic artifacts Motion Movement Musculoskeletal Orthopedics Phase Positioning Attribute Process Publishing Quality of life Relative (related person)Research Research Infrastructure Risk Roentgen Rays Skin Small Business Innovation Research Grant Sports Staging Structure Technology Testing Time Tissues Ultrasonography United States National Institutes of Health Universities Vertebral column Visual Work aging population arthropathies base bone clinical application design disability flexibility improved joint function joint injury kinematics meetings musculoskeletal imaging novel strategies public health relevance sensor skeletal soft tissue software development tool

项目摘要

DESCRIPTION (provided by applicant): Orthopaedic disorders are a leading cause of disability in the U.S., with arthritis and/or spine problems adversely affecting quality of life fo more than 20% of adults. With an aging population, the rate of disability from orthopaedic disorders has been increasing steadily. While advances in diagnostic imaging (including CT, MRI and ultrasound) have greatly improved our ability to detect structural changes in musculoskeletal tissues, they typically reveal little about joint function. There is evidence that abnormal mechanical joint function contributes significantly to the development and progression of many types of joint disease. There is, therefore, a significant clinical need for the widespread use of technologies that can identify subtle abnormalities in joint function that, if left untreate, can compromise long-term joint health. The specific goal of this Phase I SBIR project is to extend C-Motion's capabilities for bone pose (position and orientation) estimation by incorporating the bi-planar radiography imaging expertise of Dr. Tashman's laboratory at the University of Pittsburgh. Dynamic Stereo X-ray is the only currently available technology that can achieve sub-mm accuracy during a wide variety of functional movements. To date, however, the potential promise of DSX to provide a unique and powerful tool for diagnosing subtle motion disorders and identifying at-risk joints has yet to be realized as a clinical tool, ad is still an under-used clinical research tool. The successful completion of this project sets the stage for the development of a fundamentally novel approach to quantitative radiography that would turn a limited-use research tool into a powerful clinical device for dynamic assessment of musculoskeletal function. Just as cine-angiography has revolutionized diagnosis and treatment of cardiovascular disorders, widespread availability of dynamic musculoskeletal imaging could significantly improve treatment for a wide variety of orthopaedic disorders.

描述（由申请人提供）：骨科疾病是美国残疾的主要原因，关节炎和/或脊柱问题对超过 20% 的成年人的生活质量产生不利影响。随着人口老龄化，骨科疾病致残率稳步上升。虽然诊断成像（包括 CT、MRI 和超声波）的进步极大地提高了我们检测肌肉骨骼组织结构变化的能力，但它们通常很少揭示关节功能。有证据表明机械关节功能异常对多种关节疾病的发生和进展有显着影响。因此，临床上迫切需要广泛的使用可以识别关节功能细微异常的技术，如果不及时治疗，可能会损害长期的关节健康。该第一阶段 SBIR 项目的具体目标是通过结合匹兹堡大学 Tashman 博士实验室的双平面放射线照相成像专业知识，扩展 C-Motion 的骨姿势（位置和方向）估计能力。动态立体 X 射线是目前唯一可以在各种功能运动过程中实现亚毫米精度的技术。然而，迄今为止，DSX 为诊断细微运动障碍和识别危险关节提供独特而强大的工具的潜在前景尚未实现作为临床工具，ad 仍然是一种未得到充分利用的临床研究工具。该项目的成功完成为开发一种全新的定量放射成像方法奠定了基础，该方法将把有限用途的研究工具转变为用于动态评估肌肉骨骼功能的强大临床设备。正如电影血管造影彻底改变了心血管疾病的诊断和治疗一样，动态肌肉骨骼成像的广泛应用可以显着改善各种骨科疾病的治疗。