The impacts of vitamin D status and HIIT on physical performance and frailty during aging

维生素 D 状态和 HIIT 对衰老过程中身体机能和虚弱的影响

基本信息

批准号：
10229660
负责人：
Bruce R. Troen
金额：
$ 75.97万
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-15 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10229660
关键词：
Address Affect Age Age-Months Age-Years Aging American Area Attenuated Caliber Cell physiology Cessation of life Chronic Clinical Research Clinical Trials Conflict (Psychology)Data Development Economic Burden Effectiveness Elderly Epidemic Exercise Exhibits Female Functional disorder Genetic Goals Harvest Healthcare Hospitalization Human Impairment In Vitro Individual Interval training Intervention Knowledge Length Life Style Mediating MicroRNAs Mus Muscle Muscle Fibers Muscle satellite cell Older Population Outcome Physical Performance Physiological Physiological Adaptation Predisposition Publishing Quality of Care Quality of life Risk Role Serum Signal Transduction Testing Time Treatment Protocols United States Vitamin D Vitamin D supplementation age related aged aging population clinically relevant disability exercise regimen falls frailty health economics healthspan human old age (65+)improved innovation knock-down male middle age mortality mouse model muscle form novel therapeutics overexpression resilience response stem cell differentiation stem cell population stem cells

项目摘要

The impacts of vitamin D status and HIIT on physical performance and frailty during aging Frailty is a progressive age-associated condition that raises susceptibility to disability, hospitalization, and death and may affect as many as 10% of the 50 million individuals currently over the age of 65, and nearly 70% of those over the age 85. Inactivity and vitamin D insufficiency are also highly prevalent in older populations, and both are correlated with frailty. High intensity interval training (HIIT) may be a novel therapeutic strategy as HIIT safely provides substantial strength and endurance benefits with lower time commitments. The goals of this project are to characterize the role of vitamin D supplementation in age-related frailty, and whether vitamin D status can mediate the response to HIIT. Additionally, this project will investigate the role of muscle stem cells and underlying microRNA (miRNA) signaling in mediating this response. Vitamin D insufficiency from 6 to 18 months of age in mice leads to declines in physical performance. Additionally, HIIT enhances physical performance and reduces frailty in mice exercised from 24 to 28 months of age (equivalent to a 65-80 year old human). The hypothesis of this proposal is that vitamin D sufficiency is necessary to optimize stem cell function, physical performance, and the response to exercise, as well as reduce frailty during aging. To test this hypothesis, vitamin D sufficient mice will be compared to those that are vitamin D insufficient in terms of physical performance and frailty during aging and in the response to HIIT. This study will address critical gaps in the vitamin D field, which is stymied by conflicting studies regarding the role of vitamin D in regulating physical performance, frailty, and the response to exercise. The use of a mouse model in this study will allow an understanding of the longitudinal impacts of HIIT and vitamin D over the human equivalent of decades, which are otherwise difficult to determine in clinical studies due to length as well as the obfuscating contributions of lifestyle and genetic confounders. Findings from our proposed study will provide a clinical trial blueprint for successful implementation of exercise and vitamin D supplementation, thus improving the quality of care for our aging population.

维生素D状态和HIIT对体育绩效和衰老期间的脆弱的影响脆弱是一种渐进的年龄相关状况，可提高对残疾的易感性，住院和死亡，可能会影响目前超过5000万个人中的多达10％ 65岁的年龄在85岁以上的年龄中，近70％。在较旧的人群中高度普遍，两者都与脆弱相关。高强度间隔培训（HIIT）可能是一种新型的治疗策略，因为HIIT安全提供了很大的优势和耐力通过较低的时间承诺受益。该项目的目标是表征补充维生素D在与年龄相关的脆弱性中的作用，维生素D状态是否可以调解对HIIT的反应。此外，该项目将研究肌肉干细胞的作用并在介导这种反应时的基础microRNA（miRNA）信号传导。维生素D不足小鼠的6至18个月大会导致身体表现下降。此外，HIIT 提高身体表现并减少24个月大的小鼠的脆弱性（相当于65-80岁的人）。该提议的假设是维生素D 充分性是优化干细胞功能，身体性能以及对运动，并减少衰老期间的脆弱性。为了检验该假设，维生素D足够的小鼠将将维生素D在身体表现和脆弱方面进行比较在老化和对HIIT的回应中。这项研究将解决维生素D领域的关键差距，关于维生素D在调节物理中的作用的矛盾研究所困扰性能，脆弱以及对运动的反应。在本研究中使用鼠标模型将允许对HIIT和维生素D对人类等效的纵向影响的理解几十年来，由于长度以及混淆生活方式和遗传混杂因素的贡献。我们拟议的研究的发现将提供临床试验蓝图，以成功实施运动和维生素D 补充，从而提高了我们老龄化人口的护理质量。