Pilot and Exploratory Studies Core (PESC)

试点和探索性研究核心（PESC）

• 批准号: 10221555
• 负责人: ROBERT A CLARK
• 金额: $ 23.26万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10221555
• 关键词: Address; Aging; American; Animal Model; Area; Behavior Therapy; Biology of Aging; Callithrix; Capsicum; Cells; Clinical Pharmacology; Clinical Research; Clinical Trials; Communities; Disease; Dissemination and Implementation; Doctor of Philosophy; Ensure; Environment; Faculty; Financial Support; Funding; Geroscience; Goals; Grant; Health Sciences; Homeostasis; Human; Infrastructure; Institutes; Interdisciplinary Study; Intervention; Investments; Knowledge; Laboratories; Lead; Life Expectancy; Literature; Longevity; Medicine; Mentors; Methods; Modeling; Monitor; NCI-Designated Cancer Center; Pharmacology; Phase; Phase I Clinical Trials; Pilot Projects; Play; Positioning Attribute; Primates; Process; Publications; Research; Research Personnel; Resources; Science; Shock; Stress; Technology; Testing; Texas; Thinking; Training; Translating; Translational Research; Translations; Universities; Work; age related; base; bench to bedside; design; education research; effective intervention; efficacy testing; experience; healthspan; healthy aging; innovation; knowledge base; medical schools; meetings; nonhuman primate; novel; pre-clinical; pre-clinical research; preclinical study; programs; resilience; side effect; stem cell gene therapy; therapy design; translational scientist; translational study

In recent years, major advances have been made in our understanding of the basic biology of aging, leading to the identification of novel interventions with potential to prolong healthspan. In spite of exciting studies in model organisms, there has been a lack of programs and infrastructure needed to enable the translation of these discoveries to humans. The major objective of the Pilot / Exploratory Studies Core (PESC) is to promote the overarching goals of the San Antonio Older Americans Independence Center (OAIC) by developing and validating interventions to enhance healthy aging and mitigate the progression of aging-associated processes and diseases. Indeed, the PESC plays a key role in the San Antonio OAIC's central theme of translational geroscience by supporting projects that move research on the basic biology of aging from the laboratory bench to the bedside, in order to extend healthy life expectancy. The PESC will provide merit-based support for rigorously designed pilot studies that test both the efficacy and side effect profiles of promising pharmacologic, as well as non-pharmacologic cell-based and behavioral interventions, in pre-clinical marmoset models and early human clinical studies. The PESC will strive to achieve its objectives through the following specific aims: • Aim 1: To promote innovative, collaborative, multidisciplinary research to test interventions designed to extend healthy life expectancy, both in early human trials and in non-human primate marmoset models. • Aim 2: To work closely with the Resource Cores and Research Education Component to provide infrastructure, scientific support, and funding for innovative pilot proposals from mentored junior faculty investigators, as well as established researchers. • Aim 3: To encourage pilot studies that will develop and apply novel methods and technologies. • Aim 4: To sustain effective processes to solicit, review, and fund pilot projects, as well as ensure study completion, robust tracking of downstream impact, and optimal dissemination and implementation. The Core leaders, having a great deal of experience directing successful pilot project programs, will promote key alignments and interactions of PESC investigators with OAIC Resource Cores, as well as with resources in the broader scientific community. The Core will provide close oversight and guidance to PESC-supported studies from inception, during the investigative and analytical phases, through publication, and ultimately through the submission of proposals for competitive national grant funding. The PESC will seek proposals on rapidly evolving age-related scientific areas such as resilience – the capacity to return to normal functional homeostasis after stress exposure. To address the shrinking pipeline of qualified translational investigators the PESC is committed to funding meritorious proposals from early-stage investigators. Finally, we have received significant leveraging commitments, enabling PESC project investments of $290K annually and positioning the PESC to achieve both a robust return on investment and significant impact on translational geroscience.

近年来，我们对衰老的基本生物学的理解已取得了重大进步，领先 鉴定有可能延长健康范围的新干预措施。尽管有令人兴奋的研究 模型有机体，缺乏程序和基础设施来启用这些翻译 向人类发现。试验 /探索性研究核心（PESC）的主要目标是促进 通过发展和 验证干预措施以增强健康的衰老并减轻与衰老相关的过程的发展 和疾病。确实，PESC在圣安东尼奥·奥阿克（San Antonio Oaic）的转化中心主题中扮演着关键角色 通过支持从实验室基准的基本衰老生物学研究的项目来进行研究 到床边，以延长健康的预期寿命。 PESC将为基于优点的支持 严格设计的试验研究，该研究测试有希望的药物学的有效性和副作用谱， 以及非药物细胞和行为干预措施，临床前的果棒模型和早期 人类临床研究。 PESC将努力通过以下特定目标来实现其目标： •目标1：促进创新，协作，多学科研究以测试旨在的干预措施 在早期的人类试验和非人类灵长类动物模型中，延长健康的预期寿命。 •目标2：与资源核心和研究教育部分紧密合作以提供 来自指导初级教师的创新飞行员建议的基础设施，科学支持和资金 研究人员以及已建立的研究人员。 •目标3：鼓励将开发和应用新颖方法和技术的试点研究。 •目标4：维持有效的流程以征求，审查和资助试点项目，并确保研究 完成，强大的跟踪下游影响以及最佳的传播和实施。 核心领导者拥有指导成功的飞行员项目计划的丰富经验，将促进 PESC调查人员与OAIC资源核心以及资源的主要一致性和相互作用 更广泛的科学界。核心将为PESC支持的研究提供密切的监督和指导 从成立开始，在调查和分析阶段，通过出版，最终通过 提交竞争性国家赠款资金的建议。 PESC将寻求有关快速发展的建议 与年龄有关的科学领域，例如弹性 - 恢复正常功能稳态之后的能力 压力暴露。为了解决合格翻译调查员的收缩管道，PESC是承诺的 资助早期调查人员的积极提议。最后，我们收到了大量的利用 承诺，使PESC项目投资每年为29万美元，并将PESC定位为 强大的投资回报率和对转化性的重大影响。