Institute for Integration of Medicine & Science: A Partnership to Improve Health

医学整合研究所

• 批准号: 10487947
• 负责人: ROBERT A CLARK
• 金额: $ 1.74万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-28 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10487947
• 关键词: Area; Cities; Clinical Research; Clinical Sciences; Clinical Trials; Communities; Complex; County; Development; Diabetes Mellitus; Doctor of Philosophy; Effectiveness; Electronic Health Record; Fostering; Grant; Health; Health Insurance; Health Sciences; Health Services Accessibility; Healthcare Systems; Hispanic Populations; Home; Informatics; Institutes; Institution; Institutional Review Boards; Investments; Knowledge; Learning; Malignant Neoplasms; Master' s Degree; Medical; Medicine; Methods; Military Personnel; Minority; Obesity; Pathway interactions; Population; Population Heterogeneity; Positioning Attribute; Poverty; Process; Program Development; Research; Research Personnel; Research Priority; Resources; Rural; Rural Population; Science; Services; South Texas; Students; TNFSF15 gene; Time; Training; Translating; Translational Research; Veterans; Vision; Workforce Development; active duty; biomedical scientist; care delivery; care outcomes; cost; data warehouse; disparity reduction; health disparity; improved; innovation; metropolitan; military veteran; practice-based research network; programs; service member; success; translational scientist

Overall-Abstract San Antonio, positioned at the gateway to South Texas, is the 7th largest US city and the largest metropolitan area with a minority-majority population. Our 38-county region comprises an impoverished, rural, and largely Hispanic population with disproportionate rates of diabetes, obesity, and cancer, exacerbated by lack of health insurance and poor access to care. The region is home to major US military facilities, including the world’s largest military medical complex. Service members and veterans form populations with special needs. Neither better access to care nor improved care delivery, on their own, can eliminate health disparities. Innovative translational research is required to fill knowledge gaps and establish real-world effectiveness to improve health. In 2006, UT Health Science Center-San Antonio established the Institute for Integration of Medicine & Science (IIMS) as the academic home for our growing translational science initiatives, training the translational science workforce, formalizing key strategic partnerships, and creating a community of scholars within a learning healthcare system. We expanded clinical research programs, dramatically increasing access to clinical trials. We developed 6 Practice-Based Research Networks that focus on diverse ambulatory populations. We created 6 county-wide Translational Advisory Boards that support engagement through priority setting and matching with academic investigators. IIMS pioneered IRB process harmonization, resulting in rapid review times and streamlined pathways to multisite study initiation. We operate a robust pilot grant program, leveraged among our partners, with a remarkable return on investment. Our workforce development programs, with matriculants reflecting our diverse population, have graduated 133 masters degree students, supported 27 successful KL2 Scholars and 16 TL1 Scholars, and established de novo a Translational Science PhD program. Our informatics team has led electronic health record data warehouse development, fostering matches between IIMS investigators and practice-relevant research priorities. IIMS is now poised to deploy our robust portfolio of programs across our growing, leveraged, and innovative network of institutional and community partners. In this proposal, we provide clear strategies to support clinical and translational science across partner organizations, catalyze research team success, and implement programs that produce creative, collaborative, and culturally diverse translational scientists. IIMS seeks exceptionalism in translating scientific discoveries across the T1 to T4 spectrum into improved health care outcomes. Our over-arching Specific Aims are: 1. Accelerate clinical and translational research innovation and team science along the entire T1 to T4 research spectrum by providing an academic home integrated with our strategic partner institutions 2. Expand, diversify, and enhance the workforce of interdisciplinary translational biomedical scientists 3. Implement effective methods to continuously evaluate and optimize services, increase efficiencies, improve processes, endorse common metrics, and reduce costs across all IIMS programs

总体提取 圣安东尼奥（San Antonio）位于通往德克萨斯州南部的门户，是美国第七大城市， 最大的大都市地区，有少数群体人口。我们的38个县区包括一个贫穷的， 糖尿病，肥胖和癌症发生不成比例的西班牙裔人口大致，加剧了 由于缺乏健康保险和无法获得护理的机会。该地区是美国主要军事设施的所在地，包括 世界上最大的军事医疗综合体。服务成员和退伍军人组成有特殊需要的人群。 没有更好地获得护理的机会，也不能自行改善护理服务，无法消除健康差异。创新的 需要翻译研究以填补知识空白并建立现实世界的有效性以改善健康。 2006年，UT健康科学中心安东尼奥建立了医学整合研究所 科学（IIMS）是我们不断发展的转化科学计划的学术家园，培训翻译 科学劳动力，格式化关键战略伙伴关系，并在学习中建立学者社区 医疗保健系统。我们扩大了临床研究计划，大大增加了对临床试验的访问。 我们开发了6个基于实践的研究网络，这些研究网络专注于潜水员的门诊人群。我们创建了 6县范围范围的翻译咨询委员会，通过优先设置并与 学术研究人员。 IIMS开创了IRB流程的协调，导致了快速的审查时间和 流线型多站点研究计划的途径。我们运营着一个强大的试点赠款计划，在我们的 合作伙伴，具有惊人的投资回报。我们的劳动力开发计划，包括母亲 反映我们的潜水员人口，已经毕业了133位硕士学位学生，并支持27个成功的KL2 学者和16个TL1学者，并建立了从头转化科学博士学位课程。我们的信息 团队领导了电子健康记录数据仓库开发，促进了IIM之间的比赛 研究人员和实践研究重点。 IIMS现在被中毒以部署我们强大的投资组合 我们成长，杠杆和创新的机构和社区合作伙伴网络的计划。 在此提案中，我们提供了明确的策略，以支持合作伙伴的临床和翻译科学 组织，催化研究团队的成功并实施产生创造性，协作的计划， 和文化多样的转化科学家。 IIM在翻译科学发现时寻求例外主义 跨T1到T4频谱改善了医疗保健结果。我们整理的具体目的是： 1。加速临床和翻译研究创新和团队科学沿整个T1到T4 通过提供与我们的战略合作伙伴机构整合的学术房屋来提供的研究范围 2。扩展，多样化和增强跨学科转化生物医学科学家的劳动力 3.实施有效方法来连续评估和优化服务，提高效率， 改善流程，认可通用指标并降低所有IIM计划的成本

项目成果

Social Support and the Rehabilitation of Alcohol-Impaired Drivers: Drinking Motives as Moderators.

社会支持和酒后驾车者的康复：饮酒动机作为调节者。

• DOI: 10.1080/10410236.2020.1731914
• 发表时间: 2021
• 期刊: Health communication
• 影响因子: 3.9
• 作者: Moon,Tae-Joon;Mathias,CharlesW;Mullen,Jillian;Karns-Wright,TaraE;Hill-Kapturczak,Nathalie;Roache,JohnD;Dougherty,DonaldM
• 通讯作者: Dougherty,DonaldM

Development of a Mobile Application to Enhance Knowledge, Awareness and Communication of Dry Mouth Amongst Dental Practitioners and Patients: A South Texas Oral Health Network Study.

开发移动应用程序以增强牙科医生和患者对口干症的知识、意识和沟通：南德克萨斯州口腔健康网络研究。

• 发表时间: 2021
• 期刊: Texas dental journal
• 作者: Mungia,Rahma;Mendoza,Marissa;delaRosa,Elisabeth;Nguyen,Thi;Reyes,StephanieC;Schramm,Danielle;Taverna,Melanie
• 通讯作者: Taverna,Melanie

Health Equity in Patients Receiving Durvalumab for Unresectable Stage III Non-Small Cell Lung Cancer in the US Veterans Health Administration.

• DOI: 10.1093/oncolo/oyad172
• 发表时间: 2023-09-07
• 期刊: The oncologist

Further evidence supporting a potential role for ADH1B in obesity.

• DOI: 10.1038/s41598-020-80563-z
• 发表时间: 2021-01-21
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Morales LD;Cromack DT;Tripathy D;Fourcaudot M;Kumar S;Curran JE;Carless M;Göring HHH;Hu SL;Lopez-Alvarenga JC;Garske KM;Pajukanta P;Small KS;Glastonbury CA;Das SK;Langefeld C;Hanson RL;Hsueh WC;Norton L;Arya R;Mummidi S;Blangero J;DeFronzo RA;Duggirala R;Jenkinson CP
• 通讯作者: Jenkinson CP

Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation.

• DOI: 10.1016/j.psyneuen.2018.04.019
• 发表时间: 2018-08
• 期刊: Psychoneuroendocrinology
• 影响因子: 3.7
• 作者: Garrison AM;Parrott JM;Tuñon A;Delgado J;Redus L;O'Connor JC
• 通讯作者: O'Connor JC