Whole Eye Optical Coherence Tomography to Improve Eye Care

全眼光学相干断层扫描可改善眼部护理

基本信息

批准号：
10211029
负责人：
Anthony Nanlin Kuo
金额：
$ 37.08万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-12-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10211029
关键词：
3-Dimensional Accounting Adult Affect Anatomy Biomedical Engineering Biometry Caring Child Childhood Clinical Clinical Research Computer software Data Deformity Degenerative Myopia Descriptor Development Diagnostic Disease Early identification Edema Evolution Excision Eye Financial compensation Image Imaging technology Intracranial Hypertension Intracranial Pressure Laboratories Light Logistics Magnetic Resonance Imaging Measurement Morphologic artifacts Morphology Motion Myopia Ophthalmologist Optical Coherence Tomography Optics Outcome Pathologic Pathology Patient Care Patient imaging Patients Performance Peripheral Progressive Myopia Public Health Research Research Proposals Resolution Retina Shapes Site Source Swelling System Techniques Technology Testing Therapeutic Treatment Efficacy care providers case control clinical care clinical research site cost design disabling disease epidemiology study imaging biomarker imaging modality improved innovation morphometry multidisciplinary neuroimaging next generation novel retinal nerve fiber layer serial imaging skills

项目摘要

ABSTRACT This research proposal from a multi-disciplinary team including ophthalmologists and biomedical engineers seeks to improve the imaging and characterization of posterior eye deformities such as in progressive or pathologic myopic and high intracranial pressure. The three-dimensional changes seen in the posterior eye with these diseases have usually been characterized using neuro-imaging. To make this assessment more available in the clinical ophthalmic setting, we will further develop our “whole eye” optical coherence tomography (OCT) system specifically for this application. This OCT system will have hardware and software innovations to quantitatively assess the three-dimensional deformation of the posterior eye in these diseases. With these data, we can identify shape metrics which can help to distinguish pathologic from “regular” high myopia, progressive from non-progressive myopia, and for high intracranial pressure, we will assess the evolution of the eye deformation in the posterior eye over the patient’s care. These developments have both direct immediate clinical and research applicability by providing imaging biomarkers to characterize posterior eye deformation. In addition, given that a whole eye OCT system will be deployed to a second site, there will be a demonstration of the applicability of this technology outside the origin laboratory.

抽象的这项研究提案来自包括眼科医生和生物医学工程师在内的多学科团队旨在改善眼后部畸形的成像和表征，例如进行性或病理性近视和高颅压在后眼中看到的三维变化。通常使用神经影像学来表征这些疾病，以便进行更多评估。在临床眼科环境中可用，我们将进一步开发我们的“全眼”光学相干性专门用于此应用的断层扫描 (OCT) 系统该 OCT 系统将具有硬件和软件。定量评估这些疾病中眼后部三维变形的创新。有了这些数据，我们可以识别形状指标，这有助于区分病理性和“常规”高近视、非进行性近视以及高颅压，我们将评估患者护理过程中后眼变形的演变。这些进展通过提供成像技术具有直接的临床和研究适用性此外，考虑到全眼 OCT 系统将是表征眼后部变形的生物标志物。部署到第二个站点时，将演示该技术在原点之外的适用性实验室。