Imaging to predict refractive outcomes after corneal endothelial keratoplasty

影像学预测角膜内皮移植术后屈光结果

• 批准号: 8091797
• 负责人: Anthony Nanlin Kuo
• 金额: $ 20.14万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8091797
• 关键词: Address; Algorithms; Anterior; Award; Biomedical Engineering; Caring; Clinical; Clinical Research; Commit; Cornea; Corneal Endothelium; Data; Development; Device or Instrument Development; Devices; Diagnostic; Disease; Enrollment; Environment; Functional disorder; Funding; Goals; Healed; Image; In Situ; Individual; Institutional Review Boards; Intervention; Intraocular Lens Implantation; Keratoplasty; Knowledge; Lamellar Keratoplasty; Learning; Medicine; Meniscus structure of joint; Mentored Clinical Scientist Development Program; Mentors; Methods; Modeling; Morphologic artifacts; Ocular Pathology; Optical Coherence Tomography; Optics; Outcome; Patients; Penetrating Keratoplasty; Population; Principal Investigator; Procedures; Relative (related person); Research; Research Proposals; Research Training; Resolution; Resources; Scientist; Shapes; Site; Staging; Surface; Surgical Management; Techniques; Tissue Donors; Tissue Grafts; Tissues; Training; Training Support; Translations; Transplantation; Universities; Validation; base; career; career development; eye center; healing; improved; in vivo Model; insight; next generation; novel; programs; research and development

DESCRIPTION (provided by applicant): The principal investigator (PI) is currently funded by the K12 mechanism at Duke University. This career development proposal describes a continuation and expansion of the mentored training and research plan to develop the PI as an independent clinician-scientist by the conclusion of the award period. The Duke Eye Center and Duke University (sites of training) are outstanding training environments with numerous resources, interactions, facilities, and unique learning opportunities. Duke has made a strong commitment to training and supporting the next generation of clinician-scientists. The PI is similarly committed to a career as a clinician- scientist. The PI's research focuses on the development and clinical translation of diagnostic optical devices to address challenges in ophthalmic care. This research proposal uses spectral domain optical coherence tomography (SDOCT) imaging to examine the optical consequences of corneal endothelial keratoplasty (EK) and proposes a novel method to model and predict these optical changes prior to transplantation. Corneal EK has become the treatment of choice in the surgical management of corneal endothelial dysfunction such as Fuchs' corneal endothelial dystrophy but has had unintended optical consequences. The first aim describes the creation of a predictive optical model of the procedure outcome based on in situ imaging of the host and donor corneal tissues. The second aim describes validation of the image based model with clinical outcomes after corneal EK. The results of this study will provide preliminary data as the basis for an independent research proposal to better predict and target refractive results after keratoplasty. To achieve both the short- term career development and research goals, the PI will continue to receive didactic training in both biomedical engineering and clinical research and will be mentored by a multi-disciplinary team of biomedical engineers, and clinician-scientists. In the long-term, the PI will use the knowledge and training from this career development period to continue diagnostic optical device development and early stage clinical translation of these devices to address clinical ocular pathologies. PUBLIC HEALTH RELEVANCE: This project will develop new methods to study and improve corneal transplantation. Knowledge gained from this project may help to customize grafts optically for individual patients.

描述（由申请人提供）：主要研究员（PI）目前由杜克大学的K12机制资助。这项职业发展建议描述了在奖励期结束时，在指导的培训和研究计划的持续和扩展中，将PI作为独立的临床医生科学家发展。杜克眼中和杜克大学（培训地点）是出色的培训环境，拥有许多资源，互动，设施和独特的学习机会。杜克（Duke）致力于培训和支持下一代临床医生。 PI类似地致力于临床科学家的职业。 PI的研究重点是诊断光学设备的开发和临床翻译，以应对眼科护理中的挑战。该研究建议使用光谱域光学连贯断层扫描（SDOCT）成像来检查角膜内皮角膜成形术（EK）的光学后果，并提出了一种新的方法来模拟和预测移植前这些光学变化。角膜EK已成为角膜内皮功能障碍的手术治疗中的选择，例如Fuchs的角膜内皮营养不良，但具有意外的光学后果。第一个目的描述了基于宿主和供体角膜组织的原位成像的过程结果的预测光学模型。第二个目的描述了基于图像的模型的验证，该模型具有角膜EK后的临床结果。这项研究的结果将提供初步数据，作为独立研究建议的基础，以更好地预测角膜造成后的折射率和靶向折射率。为了实现短期职业发展和研究目标，PI将继续接受生物医学工程和临床研究的教学培训，并将由生物医学工程师和临床医生的多学科团队和临床医生进行指导。从长远来看，PI将利用此职业发展时期的知识和培训来继续诊断光学设备开发和这些设备的早期临床翻译来解决临床眼科病理。 公共卫生相关性：该项目将开发研究和改善角膜移植的新方法。从该项目中获得的知识可能有助于为个别患者定制移植物。