Imaging to predict refractive outcomes after corneal endothelial keratoplasty

影像学预测角膜内皮移植术后屈光结果

• 批准号: 8091797
• 负责人: Anthony Nanlin Kuo
• 金额: $ 20.14万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8091797
• 关键词: Address; Algorithms; Anterior; Award; Biomedical Engineering; Caring; Clinical; Clinical Research; Commit; Cornea; Corneal Endothelium; Data; Development; Device or Instrument Development; Devices; Diagnostic; Disease; Enrollment; Environment; Functional disorder; Funding; Goals; Healed; Image; In Situ; Individual; Institutional Review Boards; Intervention; Intraocular Lens Implantation; Keratoplasty; Knowledge; Lamellar Keratoplasty; Learning; Medicine; Meniscus structure of joint; Mentored Clinical Scientist Development Program; Mentors; Methods; Modeling; Morphologic artifacts; Ocular Pathology; Optical Coherence Tomography; Optics; Outcome; Patients; Penetrating Keratoplasty; Population; Principal Investigator; Procedures; Relative (related person); Research; Research Proposals; Research Training; Resolution; Resources; Scientist; Shapes; Site; Staging; Surface; Surgical Management; Techniques; Tissue Donors; Tissue Grafts; Tissues; Training; Training Support; Translations; Transplantation; Universities; Validation; base; career; career development; eye center; healing; improved; in vivo Model; insight; next generation; novel; programs; research and development

DESCRIPTION (provided by applicant): The principal investigator (PI) is currently funded by the K12 mechanism at Duke University. This career development proposal describes a continuation and expansion of the mentored training and research plan to develop the PI as an independent clinician-scientist by the conclusion of the award period. The Duke Eye Center and Duke University (sites of training) are outstanding training environments with numerous resources, interactions, facilities, and unique learning opportunities. Duke has made a strong commitment to training and supporting the next generation of clinician-scientists. The PI is similarly committed to a career as a clinician- scientist. The PI's research focuses on the development and clinical translation of diagnostic optical devices to address challenges in ophthalmic care. This research proposal uses spectral domain optical coherence tomography (SDOCT) imaging to examine the optical consequences of corneal endothelial keratoplasty (EK) and proposes a novel method to model and predict these optical changes prior to transplantation. Corneal EK has become the treatment of choice in the surgical management of corneal endothelial dysfunction such as Fuchs' corneal endothelial dystrophy but has had unintended optical consequences. The first aim describes the creation of a predictive optical model of the procedure outcome based on in situ imaging of the host and donor corneal tissues. The second aim describes validation of the image based model with clinical outcomes after corneal EK. The results of this study will provide preliminary data as the basis for an independent research proposal to better predict and target refractive results after keratoplasty. To achieve both the short- term career development and research goals, the PI will continue to receive didactic training in both biomedical engineering and clinical research and will be mentored by a multi-disciplinary team of biomedical engineers, and clinician-scientists. In the long-term, the PI will use the knowledge and training from this career development period to continue diagnostic optical device development and early stage clinical translation of these devices to address clinical ocular pathologies. PUBLIC HEALTH RELEVANCE: This project will develop new methods to study and improve corneal transplantation. Knowledge gained from this project may help to customize grafts optically for individual patients.

描述（由申请人提供）：首席研究员（PI）目前由杜克大学 K12 机制资助。该职业发展提案描述了指导培训和研究计划的延续和扩展，以在奖励期结束时将 PI 培养为独立的临床医生科学家。杜克眼科中心和杜克大学（培训地点）拥有出色的培训环境，拥有大量资源、互动、设施和独特的学习机会。杜克大学坚定致力于培训和支持下一代临床医生科学家。 PI 同样致力于临床医生科学家的职业生涯。 PI 的研究重点是诊断光学设备的开发和临床转化，以应对眼科护理中的挑战。该研究提案使用谱域光学相干断层扫描（SDOCT）成像来检查角膜内皮角膜移植术（EK）的光学后果，并提出了一种在移植前建模和预测这些光学变化的新方法。角膜 EK 已成为角膜内皮功能障碍（例如 Fuchs 角膜内皮营养不良）手术治疗的首选治疗方法，但会产生意想不到的光学后果。第一个目标描述了基于宿主和供体角膜组织的原位成像创建手术结果的预测光学模型。第二个目标描述了基于图像的模型与角膜 EK 后临床结果的验证。这项研究的结果将为独立研究提案提供初步数据，以更好地预测和瞄准角膜移植术后的屈光结果。为了实现短期职业发展和研究目标，PI将继续接受生物医学工程和临床研究方面的教学培训，并将受到生物医学工程师和临床科学家组成的多学科团队的指导。从长远来看，PI 将利用这一职业发展阶段的知识和培训来继续诊断光学设备的开发和这些设备的早期临床转化，以解决临床眼部病理学问题。 公众健康相关性：该项目将开发新方法来研究和改善角膜移植。从该项目中获得的知识可能有助于为个体患者定制光学移植物。