Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care

全眼光学相干断层扫描可改善屈光手术和眼部护理

基本信息

批准号：
9389496
负责人：
Anthony Nanlin Kuo
金额：
$ 39.32万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-12-01 至 2019-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9389496
关键词：
Address Affect Age Algorithmic Software Algorithms Anterior Area Back Biological Markers Biomedical Engineering Biometry Caring Cataract Extraction Clinical Clinical Research Cornea Data Dependence Development Dimensions Event Eye Functional Imaging Future Geometry Health Image Imaging Techniques Individual Investigation Knowledge Lasers Lead Light Logistics Magnetic Resonance Imaging Maps Measurement Measures Mission Modernization Modification Motion Myopia National Eye Institute Operative Surgical Procedures Ophthalmologist Ophthalmology Optical Coherence Tomography Optics Pathology Patients Performance Positioning Attribute Public Health Quality of life Research Research Personnel Research Proposals Resolution Retina Scanning Shapes Specific qualifier value Structure Surface System Techniques Technology United States National Institutes of Health Variant Vendor Vision Vision research Visual aging population base clinical care clinical diagnostics cost diagnostic biomarker imaging system improved innovation lens metrology morphometry multidisciplinary next generation public health relevance reconstruction surgery outcome trend

项目摘要

DESCRIPTION (provided by applicant): This research proposal from a multi-disciplinary team of ophthalmologists and biomedical engineers seeks to improve the accuracy of OCT representations of the eye and hence the clinical and research measurements made from OCT images. Hardware and algorithmic innovations will be made and then applied to two important clinical diagnostic measurements. In the anterior eye, accurate measurement of corneal shape determines corneal refractive power. In individuals who have undergone LASIK, however, current clinical diagnostics cannot accurately measure this shape and hence cannot measure corneal refractive power. As these individuals age, this can result in complete spectacle dependency at all distances when they later require further optical modification with cataract surgery; this gap has been recognized as a priority by the National Eye Institute. In the posterior eye, ocular shape is correlated with pathology in myopia. Ocular shape is currently obtained using magnetic resonance imaging, and the attendant logistical and cost barriers with MRI limit the widespread use and investigation of these posterior eye measures. These developments have both direct immediate clinical and research applicability by enabling the specified measures as well as future implications for spatial measurements of the eye from OCT images.

描述（由申请人提供）：这项由眼科医生和生物医学工程师组成的多学科团队提出的研究提案旨在提高眼睛 OCT 表示的准确性，从而提高 OCT 图像进行的临床和研究测量的准确性。将进行硬件和算法创新，然后应用于两个重要的临床诊断测量。在前眼中，角膜形状的准确测量决定了角膜屈光力。然而，对于接受过 LASIK 的个体，当前的临床诊断无法准确测量这种形状，因此无法测量角膜屈光力。随着这些人年龄的增长，当他们以后需要通过白内障手术进行进一步的光学矫正时，这可能会导致在所有距离上完全依赖眼镜；这一差距已被国家眼科研究所视为优先事项。在后部眼睛的形状与近视的病理相关。目前，眼部形状是使用磁共振成像获得的，而 MRI 带来的后勤和成本障碍限制了这些眼后测量的广泛使用和研究。这些进展通过实现指定的测量以及对 OCT 图像眼睛空间测量的未来影响，具有直接的临床和研究适用性。