Training the next generation of clinical neuroscientists
培训下一代临床神经科学家
基本信息
- 批准号:10390467
- 负责人:
- 金额:$ 42.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The last decade has witnessed a surge in new research findings in neuroscience. So far, however, that
impressive progress has not translated into more effective treatments, or better outcomes, for patients with
serious mental illness. Although this may just be a matter of time, another contributing factor is the lack of
physician scientists in the field of clinical neuroscience. Physician scientists are uniquely capable of linking
basic science findings to the clinical phenomenology of psychiatric illness. Indeed, scientists like these - with
both clinical and research training - are uniquely poised to bridge the gap between basic neurobiology and
clinical disease. This combination is critical for advancing our understanding of the neurobiology of psychiatric
disorders - and for developing the highly needed disease-modifying treatments for psychiatric illnesses.
One of the explanations for the lack of clinician-scientists is the difficulty in obtaining grant funding right after
residency. This proposal aims to fill that gap. In a two-three year fellowship we will provide intense research
training for a select group of psychiatrists (or PhD psychologists). Upon completion, trainees should be able to
apply successfully for individual grants and develop into independent clinical neuroscientists. We aim to create
clinician-researchers who can combine clinical knowledge with superior research skills. The long-term goal is
to help shape the new generation of leaders in clinical neuroscience. Drs. Kahn, Malaspina and New are each
renowned physician scientists who combine clinical expertise with deep research and training experience.
This program will fill an important gap in the otherwise impressive translational research program at the Icahn
School of Medicine at Mount Sinai (ISMMS), recognized as a top ten innovative research engine worldwide by
Nature. Indeed, the Departments of Neuroscience and Psychiatry are ranked #1 and #6 respectively in NIH
funding. We already have extensive experience, and a successful track record, in supporting other research
career pathways, including a Physician-Scientist residency research track for MD, PhD trainees, and the first
Combined Psychiatry Residency and PhD Training program in the US, funded by an NIMH R25 grant, of which
Dr. New is PI. We also have 6 K awardees and 2 K99/R00 investigators in our rich training programs.
The proposed T32 fellowship program is designed to train psychiatrists and clinical PhDs to formulate original
research questions on etiology, pathogenesis, course, treatment and prevention of serious mental illness. Its
focus is on patients with schizophrenia and major mood disorders. Each trainee, paired with a mentor, will
formulate a career development plan with targeted goals for acquisition of skills, presentations, publications,
gathering pilot data, and preparation of proposals for external funding - usually a career development award.
Regular meetings, internally and with an external advisory board, will monitor trainee development in relevant
milestones. We aim to help fill the dearth in clinical neuroscientists so that the recent advances in
neuroscience can be translated into better care for the millions of patients with serious mental illness.
最近十年见证了神经科学的新研究结果激增。到目前为止,
对于患有
严重的精神疾病。尽管这可能只是时间问题,但另一个原因是缺乏
临床神经科学领域的医师科学家。医师科学家具有独特的能力联系
基础科学研究结果是精神病的临床现象学。确实,这样的科学家 - 与
临床和研究培训既有唯一的准备弥合基本神经生物学和
临床疾病。这种组合对于促进我们对精神病神经生物学的理解至关重要
疾病 - 以及为精神病疾病开发急需的疾病修改治疗方法。
缺乏临床医生科学家的解释之一是很难立即获得赠款
居住。该建议旨在填补这一空白。在两个三年的奖学金中,我们将提供深入的研究
为精选的精神科医生(或博士心理学家)培训。完成后,学员应该能够
成功地申请单个赠款,并发展为独立的临床神经科学家。我们旨在创建
可以将临床知识与卓越的研究技能相结合的临床医生研究者。长期目标是
帮助塑造临床神经科学领域的新一代领导者。博士。 Kahn,Malaspina和New都是
著名的医师科学家将临床专业知识与深入研究和培训经验相结合。
该计划将填补伊坎的原本令人印象深刻的翻译研究计划的重要空白
西奈山(ISMMS)的医学院,被公认为全球十大创新研究引擎
自然。实际上,神经科学和精神病学系在NIH中分别排名第一和#6
资金。我们已经有丰富的经验和成功的往绩来支持其他研究
职业途径,包括医师科学家的医师居住研究轨道,博士学位学员和第一位
由NIMH R25赠款资助的美国精神病学居住和博士学位培训计划
New博士是PI。我们在丰富的培训计划中也有6个K获奖者和2名K99/R00调查人员。
拟议的T32奖学金计划旨在培训精神科医生和临床博士
有关病因,发病机理,病程,治疗和预防严重精神疾病的问题。它是
重点是精神分裂症和主要情绪障碍患者。每个受训者都与导师配对,将
制定一个职业发展计划,具有目标目标,以获取技能,演示,出版物,
收集试点数据,并准备外部资金的建议 - 通常是职业发展奖。
内部和外部顾问委员会的定期会议将监视与学员的发展有关
里程碑。我们旨在帮助填补临床神经科学家的缺乏,以便最近的进步
神经科学可以转化为数百万个严重精神疾病患者的更好的护理。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rene S. Kahn其他文献
P582. Local and Global Brain Ageing in Cognitive Subgroups of Early Psychosis
- DOI:
10.1016/j.biopsych.2022.02.819 - 发表时间:
2022-05-01 - 期刊:
- 影响因子:
- 作者:
Shalaila Haas;Ruiyang Ge;Nicole Sanford;Amirhossein Modabbernia;Abraham Reichenberg;Heather Whalley;Rene S. Kahn;Sophia Frangou - 通讯作者:
Sophia Frangou
Two Neuroanatomical Subtypes of Schizophrenia Defined by Multi-Site Machine Learning
- DOI:
10.1016/j.biopsych.2020.02.097 - 发表时间:
2020-05-01 - 期刊:
- 影响因子:
- 作者:
Daniel Wolf;Ganesh Chand;Dominic Dwyer;Guray Erus;Aristeidis Sotiras;Erdem Varol;Dhivya Srinivasan;Jimit Doshi;Raymond Pomponio;Alessandro Pigoni;Paola Dazzan;Rene S. Kahn;Hugo G. Schnack;Marcus V. Zanetti;Eva Meisenzahl;Geraldo F. Busatto;Benedicto Crespo-Facorro;Christos Pantelis;Stephen Wood;Chuanjun Zhuo - 通讯作者:
Chuanjun Zhuo
Poster #162 DISTURBED SELF-AGENCY IN SCHIZOPHRENIA DUE TO ABNORMAL IMPLICIT (BUT NOT EXPLICIT) PROCESSING OF ACTION-OUTCOME INFORMATION
- DOI:
10.1016/s0920-9964(12)70734-x - 发表时间:
2012-04-01 - 期刊:
- 影响因子:
- 作者:
Robert A. Renes;Lisanne Vermeulen;Rene S. Kahn;Henk Aarts;Neeltje E. van Haren - 通讯作者:
Neeltje E. van Haren
Three Distinct Neuroanatomical Subtypes of Autism Spectrum Disorder, Revealed via Machine Learning, and Their Similarities With Schizophrenia Subtypes
- DOI:
10.1016/j.biopsych.2021.02.931 - 发表时间:
2021-05-01 - 期刊:
- 影响因子:
- 作者:
Gyujoon Hwang;Edward S. Brodkin;Ganesh B. Chand;Dominic B. Dwyer;Junhao Wen;Guray Erus;Jimit Doshi;Dhivya Srinivasan;Erdem Varol;Aristeidis Sotiras;Paola Dazzan;Rene S. Kahn;Hugo G. Schnack;Marcus V. Zanetti;Eva Meisenzahl;Geraldo F. Busatto;Benedicto Crespo-Facorro;Christos Pantelis;Stephen J. Wood;Chuanjun Zhuo - 通讯作者:
Chuanjun Zhuo
Poster #53 CORTICAL THICKNESS AND CORTICAL SURFACE IN SCHIZOPHRENIA: TWO DISTINCT BUT RELEVANT PROCESSES?
- DOI:
10.1016/s0920-9964(12)70886-1 - 发表时间:
2012-04-01 - 期刊:
- 影响因子:
- 作者:
Neeltje E. van Haren;Hugo G. Schnack;Wiepke Cahn;Hilleke E. Hulshoff Pol;Rene S. Kahn - 通讯作者:
Rene S. Kahn
Rene S. Kahn的其他文献
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{{ truncateString('Rene S. Kahn', 18)}}的其他基金
Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination Center
精神病风险评估、数据集成和计算技术 (PREDICT):数据处理、分析和协调中心
- 批准号:
10457174 - 财政年份:2020
- 资助金额:
$ 42.9万 - 项目类别:
Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination Center
精神病风险评估、数据集成和计算技术 (PREDICT):数据处理、分析和协调中心
- 批准号:
10409839 - 财政年份:2020
- 资助金额:
$ 42.9万 - 项目类别:
Training the next generation of clinical neuroscientists
培训下一代临床神经科学家
- 批准号:
10649573 - 财政年份:2020
- 资助金额:
$ 42.9万 - 项目类别:
Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination Center
精神病风险评估、数据集成和计算技术 (PREDICT):数据处理、分析和协调中心
- 批准号:
10092398 - 财政年份:2020
- 资助金额:
$ 42.9万 - 项目类别:
Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination Center
精神病风险评估、数据集成和计算技术 (PREDICT):数据处理、分析和协调中心
- 批准号:
10912925 - 财政年份:2020
- 资助金额:
$ 42.9万 - 项目类别:
Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination Center
精神病风险评估、数据集成和计算技术 (PREDICT):数据处理、分析和协调中心
- 批准号:
10621232 - 财政年份:2020
- 资助金额:
$ 42.9万 - 项目类别:
Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination Center
精神病风险评估、数据集成和计算技术 (PREDICT):数据处理、分析和协调中心
- 批准号:
10256796 - 财政年份:2020
- 资助金额:
$ 42.9万 - 项目类别:
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