UMASS Small Animal Imaging Core Renovation

麻省大学小动物成像核心改造

• 批准号: 8712965
• 负责人: GEORGE J DEMARCO
• 金额: $ 47.7万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8712965
• 关键词: Acquired Immunodeficiency Syndrome; Animal Housing; Animals; Area; Blood Circulation; Cancer Center; Communicable Diseases; Diabetes Mellitus; Drug resistance; Educational process of instructing; Endocrinology; Equipment; Faculty; Funding; Future; Gene Expression; House mice; Housing; Image; Infectious Diseases Research; Institutes; Location; Longitudinal Studies; Massachusetts; Mus; Optics; Positron-Emission Tomography; Preparation; RNA; Radioisotopes; Regenerative Medicine; Research; Research Institute; Schools; Therapeutic; Universities; Vaccine Research; animal facility; comparative; gene function; gene therapy; medical schools; molecular imaging; neuroimaging; neuropsychiatry; prevent; programs; single photon emission computed tomography; stem cell biology; trafficking

Project Summary/Abstract - UMass Small Animal Imaging Core Renovation The University of Massachusetts Medical School (UMMS) is applying for funds to relocate and renovate space for its current Small Animal Imaging Core (SAIC). The current SAIC is an important component of the school's research efforts but it is located in a single 313 ft2 room on a general circulation corridor, outside of the animal facility. The size and location of the current SAIC hinders longitudinal (repeated) imaging studies and has prevented UMMS from performing ABSL-2 imaging for important infectious disease research. The SAIC houses a SPECT/CT, PET, Maestro EX and a Li-Cor near infrared imager. The latter is kept on a cart and moved to a workable location with the SAIC when needed. Because of a lack of space within the SAIC an IVIS 100 optical imager is kept in a small room within the animal facility along with the Maestro EX optical imager. Additionally, the current SAIC has no separate room for radionuclide preparation and storage; there is inadequate animal preparation space, and no space for expansion. With a rapidly growing faculty and national recognition for research excellence an expanded molecular imaging program is necessary to support the school's ongoing and future research programs. UMMS proposes to remedy these deficiencies by relocating and renovating the SAIC to a 1553 net ft2 area within its A-Level animal facility. The A-Level animal facility is the school's only animal facility with ABSL- 2 and ABSL-3 animal housing. Although mouse housing space is at a premium and the proposed space will displace mice, the Albert Sherman Center, a newly opened research and teaching building, has adequate animal housing space for the displaced animals. The Specific Aims are, and will be accomplished by: 1) Relocating the SAIC away from general pedestrian traffic to a location within the A-Level animal facility. 2) Providing sufficient space to accommodate all the current imaging equipment and having contiguous space for future expansion. 3) Providing adequate space for animal preparation, radioisotope preparation and storage and ABSL-1 and ABSL-2 animal housing. This will allow for ABSL-2 imaging in single and longitudinal studies. 4) Provide for a limited amount of equipment needed to implement Aims 1-3. This relocation and renovation of the SAIC, if funded, will support important ongoing research at UMMS, including those of the Advanced Therapeutics Cluster, Gene Therapy Center, RNA Therapeutics Institute, Center for Stem Cell Biology & Regenerative Medicine, Brudnick Neuropsychiatric Research Institute, Cancer Center, Center for AIDS Research, Center for Comparative Neuroimaging, Center for Infectious Diseases & Vaccine Research, Diabetes & Endocrinology Research Center (DERC), Institute for Drug Resistance, and the Program in Gene Function & Expression.

项目摘要/摘要 - 麻省大学小动物成像核心改造 马萨诸塞大学医学院（UMMS）正在申请资金搬迁和翻新 其当前的小动物成像核心（SAIC）的空间。现行国家工商总局是国家工商行政管理总局的重要组成部分。 学校的研究工作，但它位于一个 313 平方英尺的房间里，位于公共流通走廊上，位于 动物设施。当前 SAIC 的规模和位置阻碍了纵向（重复）成像研究 并阻止 UMMS 为重要的传染病研究进行 ABSL-2 成像。这 SAIC 拥有 SPECT/CT、PET、Maestro EX 和 Li-Cor 近红外成像仪。后者放在购物车上 并在需要时与国家工商总局一起转移到可行的地点。由于国家工商总局内部空间不足 IVIS 100 光学成像仪与 Maestro EX 光学成像仪一起放置在动物设施内的一个小房间内 成像仪。此外，目前国家工商总局没有单独的放射性核素制备和储存空间；有 动物准备空间不足，没有扩展空间。师资队伍迅速壮大，国家级 对卓越研究的认可需要扩大分子成像计划来支持 学校正在进行和未来的研究计划。 UMMS 建议通过将 SAIC 搬迁和翻新至 1553 平方英尺的净面积来弥补这些缺陷 其 A 级动物设施内的区域。 A 级动物设施是学校唯一拥有 ABSL 的动物设施- 2 和 ABSL-3 动物房。尽管鼠标居住空间非常宝贵，并且拟议的空间将 为了取代老鼠，阿尔伯特谢尔曼中心（Albert Sherman Center）是一座新开放的研究和教学大楼，拥有足够的 为流离失所的动物提供的动物居住空间。 具体目标是并且将通过以下方式实现： 1) 将国家工商总局从一般部门中转移出来 A 级动物设施内某个位置的行人交通。 2）提供足够的空间容纳 所有当前的成像设备，并具有未来扩展的连续空间。 3）提供足够的 用于动物准备、放射性同位素准备和储存以及ABSL-1和ABSL-2动物住房的空间。 这将允许在单一和纵向研究中进行 ABSL-2 成像。 4) 提供有限数量的 实施目标 1-3 所需的设备。 如果获得资助，国家工商总局的搬迁和改造将支持正在进行的重要研究 UMMS，包括先进治疗集群、基因治疗中心、RNA 治疗中心 研究所、干细胞生物学与再生医学中心、布鲁德尼克神经精神研究所、 癌症中心、艾滋病研究中心、比较神经影像中心、传染病中心 疾病与疫苗研究、糖尿病与内分泌研究中心 (DERC)、药物研究所 抗性，以及基因功能和表达中的程序。